Patents by Inventor Kosei Shioji

Kosei Shioji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphine compound, process for producing the same, and peroxide scavenger using the same
    Patent number: 8420865
    Abstract: The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: April 16, 2013
    Assignee: Fukuoka University
    Inventors: Kosei Shioji, Hiroyuki Nakagawa, Kentaro Okuma
  • PHOSPHINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEROXIDE SCAVENGER USING THE SAME
    Publication number: 20110015440
    Abstract: The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.
    Type: Application
    Filed: March 10, 2009
    Publication date: January 20, 2011
    Applicant: Fukuoka University
    Inventors: Kosei Shioji, Hiroyuki Nakagawa, Kentaro Okuma