Abstract: The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme.

Abstract: A conductive terminal includes an inner electrode part, an opening edge electrode part, and a lateral electrode part. The inner electrode part is connectable to a terminal electrode of a chip component by being inserted along an inner wall of an accommodation recess of a case. The opening edge electrode part is formed continuously to the inner electrode part. The lateral electrode part is formed continuously to the opening edge electrode part along an outer surface of the case. The inner electrode part includes a base part, a curved part, and a continuous boundary part. The base part continues to the opening edge electrode part. The curved part is formed near a tip of the base part and protrudes away from the lateral electrode part. The continuous boundary part is formed between the base part and the curved part and continuously connects them.

Abstract: Generation of artifacts caused by the FID signal is suppressed even when the parallel imaging is applied to the imaging using a spin echo type pulse sequence. In performing a pulse sequence of a spin echo type using an excitation RF pulse for exciting nuclear spin and an inversion RF pulse for inverting excited nuclear spin as a high-frequency magnetic field pulse, a high-frequency transmitter of a MRI apparatus changes the phase of the inversion RF pulse according to the phase encoding and the phase encoding number imparted for each echo signal. Specifically, the phase of the inversion RF pulse is controlled to be a quadratic function of the phase encode of the echo signal.

Abstract: An information processing apparatus determines whether or not a predetermined transfer condition for urging a target user sharing a ride in a ride-sharing vehicle with another user with a different destination to transfer between ride-sharing vehicles during movement is established, on the basis of a predicted travel route of each of a transfer source vehicle and a transfer destination vehicle. Then, in the case where the predetermined transfer condition is determined to be established, the information processing apparatus transmits transfer information for urging the target user to transfer from the transfer source vehicle to the transfer destination vehicle during movement, to a terminal associated with the transfer source vehicle and a terminal associated with the transfer destination vehicle.

Abstract: The present invention aims to provide a nucleic acid compound that hardly forms non-Watson-Crick base pairs, and an oligonucleotide containing the nucleic acid compound and showing reduced non-specific binding with nucleic acids other than the target nucleic acid. The nucleic acid compound according to the present invention is characterized in that the 2-position carbonyl group of the pyrimidine base is functionally converted (X1 and X2 are each independently S or Se), and that the 2?-position and the 4?-position are bridged in a particular structure. The oligonucleotide according to the present invention is characterized in that at least one of thymidine and uridine is the nucleic acid compound.

Abstract: Provided is an oligonucleotide conjugate comprising an oligonucleotide and two or more linearly connected asialoglycoprotein receptor-binding molecules attached to the oligonucleotide, wherein the oligonucleotide comprises a locked nucleoside analog having a bridging structure between the 4? and 2? positions, is complementary to a human PCSK9 gene, and has inhibitory activity on the expression of the human PCSK9 gene. The oligonucleotide conjugate of the present invention can be used in the field of pharmaceutical products, in particular, the field of the development and production of therapeutic agents for diseases associated with a high LDL cholesterol level.

Abstract: An electronic device including chip components each having a first terminal electrode and a second terminal electrode formed on both end faces, and a case provided with an accommodation recess in which the chip components are accommodated, and an opening edge face formed around an opening face of the accommodation recess. An individual metal terminal is attached to the case. The individual metal terminal includes an inner electrode part inserted along an inner side wall of the accommodation recess in the case for connecting to the first terminal electrode, an opening edge electrode part formed over the opening edge face to be continuous to the inner electrode part and a side electrode part formed along the outer side face of the case to be continuous to the opening edge electrode part.

Abstract: The present invention aims to provide a nucleic acid compound that hardly forms non-Watson-Crick base pairs, and an oligonucleotide containing the nucleic acid compound and showing reduced non-specific binding with nucleic acids other than the target nucleic acid. The nucleic acid compound according to the present invention is characterized in that the 2-position carbonyl group of the pyrimidine base is functionally converted (X1 and X2 are each independently S or Se), and that the 2?-position and the 4?-position are bridged in a particular structure. The oligonucleotide according to the present invention is characterized in that at least one of thymidine and uridine is the nucleic acid compound.

Abstract: Provided is an oligonucleotide conjugate comprising an oligonucleotide and two or more linearly connected asialoglycoprotein receptor-binding molecules attached to the oligonucleotide, wherein the oligonucleotide comprises a locked nucleoside analog having a bridging structure between the 4? and 2? positions, is complementary to a human PCSK9 gene, and has inhibitory activity on the expression of the human PCSK9 gene. The oligonucleotide conjugate of the present invention can be used in the field of pharmaceutical products, in particular, the field of the development and production of therapeutic agents for diseases associated with a high LDL cholesterol level.

Abstract: An electric working machine in one aspect of the present disclosure includes a motor, a setter, and a controller. The setter is configured to modifiably set a change characteristic in changing a rotational state of the motor from a low speed rotation to a high speed rotation. The high speed rotation is greater than the low speed rotation in rotational frequency of the motor.

Abstract: A power tool includes a power tool housing accommodating a motor; a battery pack interface electrically connected to the motor and being configured to be physically and electrically connected to and disconnected from a power tool interface of a battery pack; and a wireless communicator configured to be attached to or detached from the power tool housing. The wireless communicator wirelessly transmits data between the power tool and an external device using radio waves. In addition, the power tool housing includes a receptacle opening configured to accommodate the wireless communicator within the power tool housing such that no part of the wireless communicator projects or protrudes beyond an outer surface or contour of the power tool housing.

Abstract: A power tool system includes a hand-held power tool having a power tool housing accommodating a motor, and a battery pack interface electrically connected to the motor within the power tool housing. A battery pack includes a battery pack housing accommodating at least one battery cell and a power tool interface electrically connected to the at least one battery cell within the battery pack housing. The power tool interface is configured to be physically and electrically connected to and disconnected from the battery pack interface of the power tool. A wireless communicator is attached to or accommodated within the battery pack housing. The wireless communicator is configured to wirelessly communicate with an external device using radio waves while the power tool interface of the battery pack is physically and electrically connected to the battery pack interface of the hand-held power tool.

Abstract: Provided is an oligonucleotide conjugate comprising an oligonucleotide and two or more linearly connected asialoglycoprotein receptor-binding molecules attached to the oligonucleotide, wherein the oligonucleotide comprises a locked nucleoside analog having a bridging structure between the 4? and 2? positions, is complementary to a human PCSK9 gene, and has inhibitory activity on the expression of the human PCSK9 gene. The oligonucleotide conjugate of the present invention can be used in the field of pharmaceutical products, in particular, the field of the development and production of therapeutic agents for diseases associated with a high LDL cholesterol level.

Abstract: A method for manufacturing an electronic-component includes a step of forming a laminate substrate including a plurality of laminates disposed in a direction intersecting with a lamination direction via a division portion by laminating a plurality of insulator layers, and a step of singulating the plurality of laminates by removing the division portion. The step of forming the laminate substrate includes a step of forming an insulator resist layer containing an insulating material on a base material, the insulating material being a constituent material of each of the insulator layers and a step of forming the insulator layer by curing the insulator resist layer by exposure, except for at least an insulator resist portion corresponding to the division portion. The division portion including the insulator resist portion is removed by development in the step of singulating.

Abstract: A method for producing a multilayer coil component includes forming, on a main face of a substrate, a first coil conductor extending along the main face having conductivity, forming a second coil conductor and a third coil conductor apart from each other in a direction in which the first coil conductor extends and each extending from the first coil conductor in a first direction orthogonal to the main face, and forming a fourth coil conductor electrically connected to an end of the second coil conductor opposite to the first coil conductor and extending along the main face. The forming the first coil conductor includes forming, on the main face, a first insulator layer provided with a first penetration portion having a shape corresponding to the first coil conductor and exposing a part of the main face, and forming, by plating, the first coil conductor in the first penetration portion.

Abstract: A power tool includes a tool-main-body part, an electric motor as a drive source, a grip part, which extends downward from the tool-main-body part and is configured to be gripped by a user, and a power-supply unit at a tip of the grip part. The power tool includes a controller configured to control the operation of the electric motor, the controller being located on the power-supply unit, and a display controlled by the controller and configured to indicate an operating state of the electric motor. The controller and the display each have a flat-plate shape and are disposed along a surface direction with respect to one another, and the display includes a first portion that overlies the controller and a second portion that projects beyond an end edge of the controller.

Abstract: An electronic component according to an aspect of the present disclosure includes an element body and a terminal electrode. The element body includes an outer surface provided with a depression. The terminal electrode is disposed on the element body. The terminal electrode includes a first electrode portion and a second electrode portion. The first electrode portion is disposed in the depression. The second electrode portion protrudes from the depression. The second electrode portion is thicker than the first electrode portion.

Abstract: A power tool system includes a hand-held power tool having a power tool housing accommodating a motor, and a battery pack interface electrically connected to the motor within the power tool housing. A battery pack includes a battery pack housing accommodating at least one battery cell and a power tool interface electrically connected to the at least one battery cell within the battery pack housing. The power tool interface is configured to be physically and electrically connected to and disconnected from the battery pack interface of the power tool. A wireless communicator is attached to or accommodated within the battery pack housing. The wireless communicator is configured to wirelessly communicate with an external device using radio waves while the power tool interface of the battery pack is physically and electrically connected to the battery pack interface of the hand-held power tool.

Abstract: A power tool system includes a hand-held power tool having a power tool housing accommodating a motor, and a battery pack interface electrically connected to the motor within the power tool housing. A battery pack includes a battery pack housing accommodating at least one battery cell and a power tool interface electrically connected to the at least one battery cell within the battery pack housing. The power tool interface is configured to be physically and electrically connected to and disconnected from the battery pack interface of the power tool. A communicator is attached to or accommodated within the battery pack housing. The communicator is configured to wirelessly communicate with an external device.