Abstract: A vehicle door opening and closing operation device includes a cover swing mechanism and a door opening and closing operation portion to be operated by a user. The cover swing mechanism has a cover member that moves between a closed position where an operation opening portion is closed and an open position where the operation opening portion is opened. The cover swing mechanism includes a swing link unit and a swing unit. The swing link unit is swingable and movably supports the cover member between the closed position and the opening position. The swing unit includes a cam member. The swing unit presses an engagement portion of the link unit by a protruding portion provided on the cam member and swings the link unit to move the cover member. At least a part of the engagement portion overlaps the cam member in a front view.

Abstract: A pharmaceutical composition comprising Components (1) and (2): (1) 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a salt thereof; and (2) a specific amine.

Abstract: A pharmaceutical composition comprising Components (1) and (2): (1) 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a salt thereof; and (2) a compound having a partial structure containing two heteroatoms separated by at least two carbon atoms, or a sulfite thereof.

Abstract: It is an object of the present invention to provide a Japanese encephalitis preventive agent and a Japanese encephalitis vaccine agent, which are capable of imparting sufficient immunity to humans, even if these agents are used at a lower dose than the dose of a Japanese encephalitis vaccine for subcutaneous injection, or at a smaller number of administrations than the number of administrations of a Japanese encephalitis vaccine for subcutaneous injection. According to the present invention, provided is a Japanese encephalitis preventive agent, comprising a microneedle array having a sheet portion and a plurality of needle portions present on the upper surface of the sheet portion, wherein the aforementioned needle portions contain or carry an inactivated Japanese encephalitis virus.

Abstract: An object of the present invention is to provide a microneedle array in which the stability of influenza vaccine is satisfactory and the utilization efficiency of the influenza vaccine is high, and a method of producing the same. According to the present invention, provided is a self-dissolving microneedle array including a sheet portion, and a plurality of needle portions which are present on an upper surface of the sheet portion, in which the needle portion contains a water-soluble polymer, influenza vaccine, and meglumine or a salt thereof, and the influenza vaccine is administered into a body by dissolution of the needle portions.

Abstract: A vehicle door handle includes a pair of front and back covers which are connected to each other. One of the front and back covers includes a locking body. The locking body includes a leg portion configured to elastically deform and a locking hook projecting from a tip end of the leg portion. The locking hook is elastically locked and connected to a locked portion formed on the other of the front and back covers. The locking body is biased and the locking hook is press-contacted to the locked portion in a locking state of the locking body and the locked portion.