Patents by Inventor Kosuke Shimamoto

Kosuke Shimamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expressing a bifidobacterium surface-presented fusion protein
    Patent number: 8354113
    Abstract: According to the present invention, there is provided a means of expressing and displaying a protein on the cell surface of a bifidobacterium. In the gene for expressing a protein on the surface of a bifidobacterium of the present invention, a gene coding for a bifidobacterium-derived GNB/LNB substrate-binding membrane protein and a gene coding for the target protein or peptide are linked in this order from the 5? end side. Thus, a bifidobacterium transformed by introducing the gene for expressing a protein on the surface of a bifidobacterium of the present invention expresses the target protein or peptide on the surface thereof. When the target protein or peptide is an antigen protein or an antigen peptide, the transformed bifidobacterium of the present invention is useful as an oral vaccine.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: January 15, 2013
    Assignee: Morishita Jintan Co., Ltd.
    Inventors: Toshiro Shirakawa, Sakura Yamamoto, Takane Katayama, Jun Wada, Yasunobu Kano, Masanori Asada, Kosuke Shimamoto
  • GENE EXPRESSING A BIFIDOBACTERIUM SURFACE-PRESENTED FUSION PROTEIN
    Publication number: 20120177687
    Abstract: According to the present invention, there is provided a means of expressing and displaying a protein on the cell surface of a bifidobacterium. In the gene for expressing a protein on the surface of a bifidobacterium of the present invention, a gene coding for a bifidobacterium-derived GNB/LNB substrate-binding membrane protein and a gene coding for the target protein or peptide are linked in this order from the 5? end side. Thus, a bifidobacterium transformed by introducing the gene for expressing a protein on the surface of a bifidobacterium of the present invention expresses the target protein or peptide on the surface thereof. When the target protein or peptide is an antigen protein or an antigen peptide, the transformed bifidobacterium of the present invention is useful as an oral vaccine.
    Type: Application
    Filed: September 17, 2010
    Publication date: July 12, 2012
    Inventors: Toshiro Shirakawa, Sakura Yamamoto, Takane Katayama, Jun Wada, Yasunobu Kano, Masanori Asada, Kosuke Shimamoto