Abstract: A microscope image of a cultured cell cluster derived from a cancer specimen of a patient is acquired. A measured value of a gene expression level of the cluster is acquired. Based on the image, a morphological representation identifiably expressing, by a vector quantity of a plurality of dimensions, a morphological difference between a group of cell clusters cultured from the same cancer specimen and a group of cell clusters cultured from another cancer specimen is acquired. The acquired morphological representation is input to a function, which is obtained by fitting the measured value with respect to the morphological representation, to acquire a prediction value of the gene expression level. Prediction accuracy is estimated based on the prediction value and the measured value. Based on the estimated prediction accuracy, a gene related to a morphological change of the cell cluster is extracted as a gene candidate.

Abstract: A microscope image of a cultured cell cluster derived from a cancer specimen of a patient is acquired. A measured value of a gene expression level of the cluster is acquired. Based on the image, a morphological representation identifiably expressing, by a vector quantity of a plurality of dimensions, a morphological difference between a group of cell clusters cultured from the same cancer specimen and a group of cell clusters cultured from another cancer specimen is acquired. The acquired morphological representation is input to a function, which is obtained by fitting the measured value with respect to the morphological representation, to acquire a prediction value of the gene expression level. Prediction accuracy is estimated based on the prediction value and the measured value. Based on the estimated prediction accuracy, a gene related to a morphological change of the cell cluster is extracted as a gene candidate.

Abstract: There is provided a substrate processing apparatus including: a process chamber configured to accommodate and process a plurality of substrates arranged with intervals therebetween; a first nozzle extending along a stacking direction of the substrates and configured to supply a hydrogen-containing gas into the process chamber; and a second nozzle extending along the stacking direction of the substrates and configured to supply an oxygen-containing gas into the process chamber, wherein the first nozzle includes a plurality of first gas supply holes disposed in a region extending from an upper portion to a lower portion of the first nozzle corresponding to a substrate arrangement region where the substrates are arranged, and the second nozzle includes a plurality of second gas supply holes disposed at an upper portion and a lower portion of the second nozzle to correspond to upper substrates and lower substrates of the substrates.

Abstract: There is provided a technique that includes a process chamber in which a process is performed to a substrate, the process including forming a film containing a main element, a first nozzle configured to supply a precursor containing the main element to the substrate in the process chamber, and a second nozzle configured to supply a reactant to the substrate in the process chamber. The first nozzle includes a first ceiling hole provided at a ceiling portion of the first nozzle and opened in a vertical direction, and a plurality of first side holes provided at a side portion of the first nozzle and opened in a horizontal direction. An opening area of the first ceiling hole is larger than an opening area of each of the plurality of first side holes.

Abstract: A fuel cell stack includes a stack body formed by stacking a plurality of power generation cells together in a stacking direction, the power generation cells each having a separator, and a pair of end plates provided at both ends of the stack body in the stacking direction. Further, the fuel cell stack includes a support bar extending between the pair of end plates in the stacking direction and configured to engage with an outer peripheral portion of the separator. The width of the support bar is decreased gradually from one end and the other end toward a central portion in an extension direction in which the support bar extends.

Abstract: Provided is a technique capable of suppressing the occurrence of by-products by suppressing adhesion of the by-products. A substrate processing apparatus includes: a reaction tube where a substrate is processed; a furnace opening unit disposed at a lower end of the reaction tube and having an upper surface and an inner circumferential surface, the furnace opening unit including: a concave portion disposed on the upper surface; and a convex portion having at least one notch connecting the concave portion to the inner circumferential surface; a cover covering at least the inner circumferential surface with a predetermined gap therebetween; and a gas supply unit configured to supply a gas to the concave portion.

Abstract: A substrate processing apparatus includes a reaction tube defining a substrate processing chamber; a gas inlet provided at a lower portion of the reaction tube to supply a process gas; a first buffer unit for temporarily retaining the process gas, the first buffer unit at a first side of an inner surface of the reaction tube and includes a plurality of gas supply holes; and a gas outlet provided at a second side of the inner surface of the reaction tube opposite to the first side, to exhaust the process gas from the process chamber. The gas supply holes are provided from an upper end portion of the first buffer unit to a lower end portion of the first buffer unit, and the process gas is supplied through the plurality of gas supply holes into the process chamber, passes through the process chamber, and exhausted through the gas outlet.

Abstract: A fuel cell stack includes a plurality of power generation cells and a stack case. A tab protrudes from an outer marginal portion of each of the power generation cells. The stack case contains the plurality of power generation cells that are stacked together in a stacking direction, and includes a pair of end plates provided at both ends of the power generation cells in the stacking direction. Further, the fuel cell stack includes a support bar extending inside the stack case in the stacking direction, and including a recess capable of accommodating the tab. One end of the support bar is joined to one of the end plates, and the other end of the support bar is supported by the other of the end plates.

Abstract: An outer surface of an upper wall of a stack case of a fuel cell system provided in a fuel cell vehicle includes a first outer surface, a second outer surface which is positioned closer than the first outer surface to a cell stack body, and an outer surface coupling part. Space is formed between a first upper wall of the upper wall and the cell stack body. Tabs and bus bars are disposed in the space.

Abstract: Described herein is a technique capable of suppressing deposits. According to one aspect of the technique, there is provided a method including: (a) supplying a source gas into a process chamber through a source gas nozzle while heating the process chamber; and (b) supplying a reactive gas into the process chamber, wherein (a) and (b) are alternately performed one by one to form a film on the plurality of the substrates while satisfying conditions including: (i) a supply time of the source gas in (a) in each cycle is 20 seconds or less; (ii) a pressure of the source gas in the source gas nozzle in (a) is 50 Pa or less; (iii) an inner temperature of the process chamber in (a) is 500° C. or less; and (iv) number of cycles performed continuously to form the film on the plurality of the substrates is 100 cycles or less.

Abstract: An amount of particles generated when a source material is used is suppressed. A substrate is loaded into a process chamber, and the source material is sequentially flowed into an evaporator, and a mist filter constituted by assembling a plurality of at least two types of plates including holes disposed at different positions to be evaporated and supplied into the process chamber to process the substrate, and then, the substrate is unloaded from the process chamber.

Abstract: There is provided a technique that includes: a process chamber in which a process of forming a film containing a main element on a substrate is performed; a first nozzle configured to supply a precursor containing the main element to the substrate in the process chart; a second nozzle separated from the first nozzle and configured to supply the precursor to the substrate in the process chamber; a third nozzle configured to supply a reactant to the substrate in the process chamber; and a plurality of first exhaust ports configured to exhaust an internal atmosphere of the process chamber, wherein each of the plurality of first exhaust ports is disposed at a position which does not face a first gas ejection hole of the first nozzle and a second gas ejection hole of the second nozzle, in a plan view.

Abstract: The present invention provides a method for evaluating a protrusion-forming ability of cell spheroids, comprising step (a) of imaging a cell spheroid labeled with a fluorescent substance using a fluorescence microscope at a resolution capable of identifying individual cells, and acquiring a plane tomographic image of a fluorescence emitted from the fluorescent substance, step (b) of analyzing the plane tomographic image acquired in step (a) to determine a protrusion part of the cell spheroid, and step (c) of evaluating a protrusion-forming ability of the cell spheroid based on the protrusion part determined in step (b).

Abstract: A fuel cell stack includes a load receiver provided in a first separator, and a contact portion. The load receiver includes a protrusion protruding outward from an outer peripheral portion of the first separator. The protrusion includes a protrusion body positioned at the center in a width direction of the protrusion, and a pair of expansions expanded in the width direction from both ends of the protrusion body in the width direction. When the load receiver contacts the contact portion, only a top portion of the expansion contacts the contact portion.

Abstract: A permanent magnet is expressed by a composition formula: RpFeqMrCusCo100-p-q-r-s. M is at least one element selected from the group consisting of Zr, Ti, and Hf. The magnet includes a crystal grain having a main phase including a TbCu7 crystal phase, and a volume ratio of the TbCu7 crystal phase to the main phase is 95% or more.

Abstract: An outer surface of an upper wall of a stack case of a fuel cell system provided in a fuel cell vehicle includes a first outer surface, a second outer surface which is positioned closer than the first outer surface to a cell stack body, and an outer surface coupling part. Space is formed between a first upper wall of the upper wall and the cell stack body. Tabs and bus bars are disposed in the space.

Abstract: A substrate processing apparatus includes a process chamber accommodating a substrate; a gas supply system; and an exhaust system. The supply system includes a vaporizer and a mist filter, the mist filter including a plurality of first plates and a plurality of second plates. Each of the first plates includes a first plate portion having a plurality of first grooves on a surface thereof and a first flow path. Each of the second plates includes a second plate portion having a plurality of second grooves on a surface thereof and a second flow path. When the plurality of first and second plates are arranged alternatively, the plurality of first grooves are configured to face the second flow path and the plurality of second grooves are configured to face the first flow path, such that the first flow path and the second flow path are not in-line.

Abstract: A fuel cell stack includes a stack body formed by stacking a plurality of power generation cells together in a stacking direction, the power generation cells each having a separator, and a pair of end plates provided at both ends of the stack body in the stacking direction. Further, the fuel cell stack includes a support bar extending between the pair of end plates in the stacking direction and configured to engage with an outer peripheral portion of the separator. The width of the support bar is decreased gradually from one end and the other end toward a central portion in an extension direction in which the support bar extends.

Abstract: A fuel cell stack includes a plurality of power generation cells and a stack case. A tab protrudes from an outer marginal portion of each of the power generation cells. The stack case contains the plurality of power generation cells that are stacked together in a stacking direction, and includes a pair of end plates provided at both ends of the power generation cells in the stacking direction. Further, the fuel cell stack includes a support bar extending inside the stack case in the stacking direction, and including a recess capable of accommodating the tab. One end of the support bar is joined to one of the end plates, and the other end of the support bar is supported by the other of the end plates.

Abstract: A manufacturing method includes providing a cell stack including fuel cells and has a first end and a second end. A first end plate is provided at the first end of the cell stack. The first end plate has a first end plate through hole. A second end plate is provided at the second end of the cell stack. A connecting member is provided to connect the first end plate and the second end plate. A first knock is inserted into the first end plate through hole and into a first connecting member installing hole. A first seal is located between the first knock and the first end plate in the first end plate through hole. The first end plate is moved in the stacking direction to contact the connecting member. A fastening member is inserted into the first knock.