Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing in a culture medium a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, and collecting the L-amino acid from the culture medium and/or cells of the bacterium, wherein the bacterium has been modified to have one or more of the following modifications: (A) modification of reducing the activity of a BudA protein; (B) modification of reducing the activity of a BudB protein; (C) modification of reducing the activity of a BudC protein; (D) modification of reducing the activity of a PAJ_3461 protein; (E) modification of reducing the activity of a PAJ_3462 protein; and (F) modification of reducing the activity of a PAJ_3463 protein.

Abstract: Provided is a production method for a completed component, the production method including: a first step for performing finite element analysis to determine an amount of change at evaluation sites of the completed component on a three-dimensional model of the completed component that occurs when displacement is applied to joining areas between the individual parts on the three-dimensional model; a second step for extracting combinations of critical evaluation sites having a relatively large amount of change among the evaluation sites on the three-dimensional model and their corresponding critical joining areas among the joining areas on the three-dimensional model; a third step for generating regression models through Lasso regression; a fourth step for performing Bayesian estimation; a fifth step for selecting an adjustment site of the individual parts; and a sixth step for producing the completed component.

Abstract: Included are: an averaging process of performing averaging on measurement data in accordance with a ratio of amounts of deformation calculated in a first analysis process at other evaluation portions than a certain evaluation portion, with respect to the certain evaluation portion; an adjustment process of adjusting the ratio to achieve a higher correlation between a ratio of rigidity calculated from results of analyses between a second member and a first member and a ratio of movement calculated from the measurement data; and a rigidity changing process of changing, when a value of the measurement data at one of the evaluation portions on the completed member exceeds an allowable value, rigidity of the second member based on the correlation having undergone the adjustment in the adjustment process to allow the value of the measurement data to be below the allowable value.

Abstract: A vehicle control apparatus sets a target speed of a vehicle such that a maximum value of the target speed is a first speed during a parking assist control. The vehicle control apparatus executes the parking assist control with maintaining a speed of the vehicle at a speed equal to or slower than a predetermined speed limit value slower than the first speed when a predetermined condition that the vehicle moves along a downward slope, is satisfied when a first electric power source device is in a normal state during the parking assist control. At least one of a braking apparatus and a shift change apparatus executes a stopping control of stopping the vehicle when a malfunction occurs in the first electric power source device during the parking assist control.

Abstract: A resin composition contains an ethylene-vinyl alcohol copolymer, wherein the ratio (Y/Z) of a lactone ring content (Y) to the sum (Z) of a carboxylic acid content (X) and the lactone ring content (Y) in terminal structures of the ethylene-vinyl alcohol copolymer is not less than 55 mol %, and at least one of a cinnamic acid component, a lubricant, a boron compound, and a conjugated polyene compound is present as a thermally stabilizing substance in a predetermined proportion based on the weight of the resin composition. Therefore, the resin composition is excellent in high-temperature thermal decomposition suppressing effect and thermal stability, and is free from odor emanation and coloration even if being processed at a higher temperature.

Abstract: Provided is a parking assist apparatus for a vehicle, the parking assist apparatus including a first module configured to set, as a movement path, a path along which the vehicle is movable to a target position, and determine movement assist information for moving the vehicle along the movement path; and a second module configured to execute parking assist control such that the vehicle moves in accordance with the determined movement assist information, the second module being further configured to, when an occupant performs a first operation before the vehicle has reached the target position, stop the vehicle, and execute pause processing for maintaining the movement assist information.

Abstract: A parking assistance device performs parking assistance control including steering angle control for changing a steering angle of a vehicle, driving force control for controlling a driving force of the vehicle, and braking force control for controlling a braking force of the vehicle. The parking assistance device notifies an occupant of a driving operation to be performed by the occupant, including a moving operation on a shift lever and an operation on a brake pedal when the vehicle reaches a switching position where a traveling direction of the vehicle is to be switched during performing the parking assistance control. When the driving operation is performed by the occupant, the parking assistance device restarts the parking assistance control at a timing when the occupant stops the operation on the brake pedal.

Abstract: Provided is a method of producing an L-amino acid such as L-glutamic acid and the like. An L-amino-acid is produced by cultivating a coryneform bacterium having L-amino acid-producing ability in a culture medium, which has been modified so as to have one or more of the following modifications: (A) a modification for increasing activity of acetate kinase, (B) a modification for increasing activity of fructose-1,6-bisphosphatase, (C) a modification for decreasing activity of pyruvate dehydrogenase, (D) a modification for decreasing activity of aspartate transaminase, and (E) a modification for decreasing activity of malic enzyme; and collecting the L-amino acid from the culture medium and/or the bacterial cells.

Abstract: A lens barrel includes a lens and a holding member holds the lens. A guide barrel guides the holding member linearly movably in an optical axis direction of the lens. A cam ring is rotatably held about an optical axis of the lens with respect to the guide barrel and surrounds the guide barrel. The cam ring has a first contact portion opposed to the fixed member fixed to the guide barrel, in the optical axis direction. The fixed member has a second contact portion opposed to the first contact portion in the optical axis direction. When the cam ring is moved by an external force to approach the fixed member in the optical axis direction, the first contact portion and the second contact portion are brought into contact with each other, whereby rotation of the cam ring about the optical axis is restricted.

Abstract: An ethylene-vinyl alcohol copolymer composition that contains an ethylene-vinyl alcohol copolymer (A), an unmodified polyolefin (B), and an acid-modified polyolefin (C). The mass ratio [(B)/(C)] between the unmodified polyolefin (B) and the acid-modified polyolefin (C) is 75/25 to 1/99. The melt viscosity ratio [(?1)/(?2)] between the melt viscosity (?1) of the composition at 210° C. and a shear rate of 18 (sec-1) and the melt viscosity (?2) of the composition at 210° C. and a shear rate of 365 (sec-1) is 5.6 or more. The mass ratio [(A)/((B)+(C))] between the ethylene-vinyl alcohol copolymer (A) and the total content of the unmodified polyolefin (B) and the acid-modified polyolefin (C) is 60/40 or more and less than 75/25.

Abstract: A vehicle control apparatus has a first electric power source device and a second electric power source device installed in a vehicle. The vehicle control apparatus monitors a charged electric amount of a second electric power source device after starting to execute a parking assist control. When the charged electric amount becomes smaller than a predetermined first threshold, the vehicle control apparatus executes a stopping control of controlling at least one of a braking apparatus and a shift change apparatus to stop the vehicle.

Abstract: Provided is a control apparatus for a vehicle configured to perform parking assist control, the control apparatus including a first power supply device, a second power supply device, and a power supply circuit, the power supply circuit being configured to, when an abnormality occurs in the first power supply device during the performance of the parking assist control, supply an electric power from the second power supply device to a braking device and a shift switching device, and the braking device and the shift switching device being configured to operate such that a timing at which a current flowing from the second power supply device to the braking device reaches a maximum value and a timing at which a current flowing from the second power supply device to the shift switching device reaches a maximum value do not overlap.

Abstract: A vehicle driving apparatus including a first oil pump driven by an internal combustion engine; a second oil pump connected to a torque transmission portion transmitting a driving force of the second motor generator to a drive wheel; a hydraulic circuit configured so that a lubricating oil is supplied from the second oil pump to a lubrication portion in a first mode in which a vehicle travels while stopping the internal combustion engine, and the lubricating oil is supplied from the first and second oil pumps to the lubrication portion in a second mode in which the vehicle travels while driving the internal combustion engine; a slip detector detecting a slip state of the drive wheel, and a control unit switching to the second mode when the slip state is detected during the first mode.

Abstract: In a solid-state imaging element that performs AD conversion for each pixel, image quality degradation when resolution is lowered is suppressed without wastefully consuming power. The solid-state imaging element includes a plurality of pixels. Each of the plurality of pixels is provided with a comparison unit, an addition circuit, and a data storage unit. The comparison unit generates a difference signal obtained by amplifying a difference between an analog pixel signal to which a predetermined coordinate is assigned and a predetermined reference signal. The addition circuit generates an addition signal by performing analog addition of the difference signal and a difference signal regarding another coordinate adjacent to the predetermined coordinate. The data storage unit holds a digital signal indicating a time when an output signal of the comparison unit corresponding to the addition signal is inverted.

Abstract: The purpose of the present invention is to establish a more precise method for evaluating long-run moldability and, based on this method, improve long-run moldability of a resin composition containing an EVOH-based resin and a nylon 6-based polyamide. Provided is a resin composition having improved long-run moldability and containing an EVOH-based resin and a nylon 6-based polyamide, wherein the amount of ?-caprolactam is 200 ppm or less. When the resin composition comprises an EVOH-based resin and a nylon 6-based polyamide, contacting the resin composition with water can reduce the amount of ?-caprolactam.

Abstract: A vehicle driving apparatus including a first oil pump driven by an internal combustion engine; a second oil pump connected to a torque transmission portion transmitting a driving force of the second motor generator to a drive wheel; a hydraulic circuit configured so that a lubricating oil is supplied from the second oil pump to a lubrication portion in a first mode in which a vehicle travels while stopping the internal combustion engine, and the lubricating oil is supplied from the first and second oil pumps to the lubrication portion in a second mode in which the vehicle travels while driving the internal combustion engine; a slip detector detecting a slip state of the drive wheel, and a control unit switching to the second mode when the slip state is detected during the first mode.

Abstract: Ethylene-vinyl alcohol copolymer pellets comprise an ethylene-vinyl alcohol copolymer and water, and have a water content of not higher than 0.5 wt. %, wherein the ratio (Y/Z) of a lactone ring content (Y) to the sum (Z) of a carboxylic acid content (X) and the lactone ring content (Y) in terminal structures of the ethylene-vinyl alcohol copolymer is not less than 60 mol %. The pellets are excellent in high-temperature thermal decomposition-suppressing effect and thermal stability, and are free from odor emanation and coloration even if being processed at a higher temperature.

Abstract: To provide a method for purifying an antibody to a sufficient degree of purity for therapeutic use in humans by removing impurities contained in a solution efficiently while reducing production cost and the purification period in the purification of the antibody. It was found that an antibody can be reliably purified to a high degree of purity by an activated carbon material, regardless of the amounts or species of impurities co-present, and that high viral clearance can be attained reliably. Based on the finding, a treatment with an activated carbon material could be used in place of AEX chromatography achieving viral clearance in a step of purifying a therapeutic antibody using CHO cells. As a result, an antibody can be simply and effectively purified to a sufficient degree of purity for therapeutic use in humans compared to a conventional purification method, while reducing production cost.

Abstract: A vehicle control apparatus has a first electric power source device and a second electric power source device installed in a vehicle. The vehicle control apparatus monitors a charged electric amount of a second electric power source device after starting to execute a parking assist control. When the charged electric amount becomes smaller than a predetermined first threshold, the vehicle control apparatus executes a stopping control of controlling at least one of a braking apparatus and a shift change apparatus to stop the vehicle.