Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: An electrical toothbrush includes an electrical toothbrush main body including a drive source of a brush; an orientation sensor configured to detect an orientation of the electrical toothbrush main body; and a controller configured to switch an operation mode of the electrical toothbrush according to a result of comparing an orientation value, which is a value calculated from an output of the orientation sensor, and a threshold value set in advance. A threshold value used for switching determination from an operation mode to an operation mode, and a threshold value used for switching determination from the operation mode to the operation mode are set to different values.

Abstract: An electrical toothbrush includes an electrical toothbrush main body including a drive source of a brush; an orientation sensor configured to detect an orientation of the electrical toothbrush main body; and a controller configured to switch an operation mode of the electrical toothbrush according to a result of comparing an orientation value, which is a value calculated from an output of the orientation sensor, and a threshold value set in advance. A threshold value used for switching determination from an operation mode to an operation mode, and a threshold value used for switching determination from the operation mode to the operation mode are set to different values.