Patents by Inventor Kotaro Sasaki

Kotaro Sasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200181568
    Abstract: The invention provides a method for inducing human primordial germ cell-like (PGC-like) cells from human pluripotent stem cells, with high efficiency and high reproducibility, and a cell surface marker for identifying human PGC-like cells. In particular, the invention provides a method for producing a human PGC-like cell from a human pluripotent stem cell, includes a step of producing a mesoderm-like cell by culturing a human pluripotent stem cell in a culture medium comprising activin A and a GSK3? inhibitor, and a step of culturing the mesoderm-like cell in a culture medium containing BMP. The invention also provides a method for producing an isolated human PGC-like cell, which includes the aforementioned two steps and the additional step of selecting a cell positive to at least one cell surface marker selected from the group consisting of PECAM (CD31), INTEGRINa6 (CD49f), INTEGRIN?3 (CD61), KIT (CD117), EpCAM, PODOPLANIN and TRA1-81.
    Type: Application
    Filed: January 2, 2020
    Publication date: June 11, 2020
    Applicant: Kyoto University
    Inventors: Mitinori SAITOU, Kotaro SASAKI, Shihori YOKOBAYASHI
  • Patent number: 10680249
    Abstract: Nitride stabilized metal (M or Pt(M)) nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: June 9, 2020
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Patent number: 10563171
    Abstract: The invention provides a method for inducing human primordial germ cell-like (PGC-like) cells from human pluripotent stem cells, with high efficiency and high reproducibility, and a cell surface marker for identifying human PGC-like cells. In particular, the invention provides a method for producing a human PGC-like cell from a human pluripotent stem cell, includes a step of producing a mesoderm-like cell by culturing a human pluripotent stem cell in a culture medium comprising activin A and a GSK3? inhibitor, and a step of culturing the mesoderm-like cell in a culture medium containing BMP. The invention also provides a method for producing an isolated human PGC-like cell, which includes the aforementioned two steps and the additional step of selecting a cell positive to at least one cell surface marker selected from the group consisting of PECAM (CD31), INTEGRIN?6 (CD49f), INTEGRIN?3 (CD61), KIT (CD117), EpCAM, PODOPLANIN and TRA1-81.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: February 18, 2020
    Assignee: Kyoto University
    Inventors: Mitinori Saitou, Kotaro Sasaki, Shihori Yokobayashi
  • Patent number: 10501321
    Abstract: Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 10, 2019
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Publication number: 20190198885
    Abstract: Nitride stabilized metal (M or Pt(M)) nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 27, 2019
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Publication number: 20180187147
    Abstract: The invention provides a method for inducing human primordial germ cell-like (PGC-like) cells from human pluripotent stem cells, with high efficiency and high reproducibility, and a cell surface marker for identifying human PGC-like cells. In particular, the invention provides a method for producing a human PGC-like cell from a human pluripotent stem cell, includes a step of producing a mesoderm-like cell by culturing a human pluripotent stem cell in a culture medium comprising activin A and a GSK3? inhibitor, and a step of culturing the mesoderm-like cell in a culture medium containing BMP. The invention also provides a method for producing an isolated human PGC-like cell, which includes the aforementioned two steps and the additional step of selecting a cell positive to at least one cell surface marker selected from the group consisting of PECAM (CD31), INTEGRIN?6 (CD49f), INTEGRIN?3 (CD61), KIT (CD117), EpCAM, PODOPLANIN and TRA1-81.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Applicant: Kyoto University
    Inventors: Mitinori SAITOU, Kotaro SASAKI, Shihori YOKOBAYASHI
  • Patent number: 9976199
    Abstract: Embodiments of the disclosure relate to intermetallic nanoparticles. Embodiments include nanoparticles having an intermetallic core including a first metal and a second metal. The first metal may be palladium and the second metal may be at least one of cobalt, iron, nickel, or a combination thereof. The nanoparticles may further have a shell that includes palladium and gold.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: May 22, 2018
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Kurian A. Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Publication number: 20180134559
    Abstract: Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 17, 2018
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Patent number: 9882222
    Abstract: Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. The nitride stabilized nanoparticles may be fabricated by a process in which a core is coated with a shell layer that encapsulates the entire core. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 30, 2018
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Patent number: 9580823
    Abstract: A catalytic composition from earth-abundant transition metal salts and biomass is disclosed. A calcined catalytic composition formed from soybean powder and ammonium molybdate is specifically exemplified herein. Methods for making the catalytic composition are disclosed as are electrodes for hydrogen evolution reactions comprising the catalytic composition.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: February 28, 2017
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Wei-Fu Chen, Shweta Iyer, Shilpa Iyer, Kotaro Sasaki, James T. Muckerman, Etsuko Fujita
  • Publication number: 20170037494
    Abstract: Embodiments of the disclosure relate to intermetallic nanoparticles. Embodiments include nanoparticles having an intermetallic core including a first metal and a second metal. The first metal may be palladium and the second metal may be at least one of cobalt, iron, nickel, or a combination thereof. The nanoparticles may further have a shell that includes palladium and gold.
    Type: Application
    Filed: April 22, 2015
    Publication date: February 9, 2017
    Inventors: Kurian A. Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Publication number: 20160283867
    Abstract: To effectively call in customers. Provided are a frame display unit that displays frames that respectively correspond to a plurality of tables arranged in a store on a screen of a store terminal 2, a vacant seat presence/absence change unit that, in a case where one frame has been selected from the frames displayed on the screen, changes vacant seat presence/absence information that is stored in a vacant seat presence/absence information DB 5b in correspondence with the selected frame to a content indicating that it is not vacant, a vacant seat status update unit that updates vacant seat status information that indicates what extent of vacancy is present in tables in a store stored in a vacant seat status information DB 5c on the basis of the vacant seat presence/absence information, and a vacant seat status providing unit that provides the vacant seat status information to a user terminal 3.
    Type: Application
    Filed: November 10, 2014
    Publication date: September 29, 2016
    Inventors: Kotaro SASAKI, Hiroyuki SHIBUYA
  • Publication number: 20160160376
    Abstract: An apparatus for the synthesis and treatment of electrocatalyst particles in batch or continuous fashion is provided. In one embodiment, the apparatus is comprised of a three-electrode cell which includes a cell body electrode, a reference electrode and a floating counter electrode. The floating counter electrode may be disposed inside a counter electrode compartment which is adapted to float in a slurry containing a plurality of nanoparticles and an electrolyte.
    Type: Application
    Filed: November 19, 2015
    Publication date: June 9, 2016
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES, LLC
    Inventors: Radoslav Adzic, Junliang Zhang, Kotaro Sasaki
  • Publication number: 20150252484
    Abstract: A catalytic composition from earth-abundant transition metal salts and biomass is disclosed. A calcined catalytic composition formed from soybean powder and ammonium molybdate is specifically exemplified herein. Methods for making the catalytic composition are disclosed as are electrodes for hydrogen evolution reactions comprising the catalytic composition.
    Type: Application
    Filed: October 1, 2013
    Publication date: September 10, 2015
    Applicant: BROOKHAVEN SCIENCE ASSOCIATES LLC
    Inventors: Wei-Fu Chen, Shweta Iyer, Shilpa Iyer, Kotaro Sasaki, James T. Muckerman, Etsuko Fujita
  • Publication number: 20150147682
    Abstract: Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. The nitride stabilized nanoparticles may be fabricated by a process in which a core is coated with a shell layer that encapsulates the entire core. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Inventors: Kurian Abraham Kuttiyiel, Kotaro Sasaki, Radoslav R. Adzic
  • Patent number: 9017530
    Abstract: An apparatus and method for synthesis and treatment of electrocatalyst particles in batch or continuous fashion is provided. In one embodiment, the apparatus comprises a sonication bath and a two-compartment chamber submerged in the sonication bath. The upper and lower compartments are separated by a microporous material surface. The upper compartment comprises a cover and a working electrode (WE) connected to a Pt foil contact, with the foil contact connected to the microporous material. The upper chamber further comprises reference counter electrodes. The lower compartment comprises an electrochemical cell containing a solution of metal ions. In one embodiment, the method for synthesis of electrocatalysts comprises introducing a plurality of particles into the apparatus and applying sonication and an electrical potential to the microporous material connected to the WE.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: April 28, 2015
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Radoslav Adzic, Junliang Zhang, Kotaro Sasaki
  • Publication number: 20150083585
    Abstract: The present invention provides molybdenum and tungsten nanostructures, for example, nanosheets and nanoparticles, and methods of making and using same, including using such nanostructures as catalysts for hydrogen evolution reactions.
    Type: Application
    Filed: October 24, 2014
    Publication date: March 26, 2015
    Applicant: Brookhaven Science Associates, LLC
    Inventors: Kotaro Sasaki, Wei-Fu Chen, James T. Muckerman, Radoslav R. Adzic
  • Patent number: 8966991
    Abstract: An apparatus for sensing strain or stress includes a body including magnetic shape-memory alloy (MSMA) material, having a first axis. A first drive coil and first sensor coil are wound around the body about the first axis. The drive coil is coupled to a power source and configured to generate an alternating magnetic field on the body. The first sensor coil is configured to detect changes in inductance of the body due to changes in magnetic permeability of the body with deformation thereof.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: March 3, 2015
    Assignee: Boise State University
    Inventors: Kari Ullakko, Kotaro Sasaki, Peter Müllner
  • Publication number: 20140302424
    Abstract: Disclosed are catalysts, especially catalytic anodes, useful for catalyzing reactions in fuel cells and in other environments. The catalysts have a substrate base made of iridium and/or ruthenium. There is a very thin coating on the substrate which is a mix of platinum and at least one metal selected from gold, palladium, iridium, rhodium, ruthenium, rhenium, and osmium. The anodes are resistant to carbon monoxide adulteration in fuel cells.
    Type: Application
    Filed: June 10, 2014
    Publication date: October 9, 2014
    Inventors: Emmanouil Mavrikakis, Anand U. Nilekar, Radoslav R. Adzic, Kotaro Sasaki
  • Publication number: 20140065516
    Abstract: Disclosed are catalysts, especially catalytic anodes, useful for catalyzing reactions in fuel cells and in other environments. The catalysts have a substrate base made of iridium and/or ruthenium. There is a very thin coating on the substrate which is a mix of platinum and at least one metal selected from gold, palladium, iridium, rhodium, ruthenium, rhenium, and osmium. The anodes are resistant to carbon monoxide adulteration.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 6, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Emmanouil Mavrikakis, Anand U. Nilekar, Radoslav R. Adzic, Kotaro Sasaki