Patents by Inventor Kotoku Kurachi

Kotoku Kurachi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequences for gene regulation and methods of use thereof
    Patent number: 7341871
    Abstract: The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or in a liver-specific manner. The invention further provides methods of using the regulatory nucleic acid sequences provided herein for age-related and/or liver-specific expression of nucleotides seuqences of interest. The invention also provides host cells and transgenic non-human animals which harbor the regulatory nucleic acid sequences of the invention. The compositions and methods of the invention are useful in regulating expression of a nucleotide sequence of interest in an age-related and/or liver-specific manner.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: March 11, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Kotoku Kurachi, Sumiko Kurachi
  • Nucleotide sequences for gene regulation and methods of use thereof
    Publication number: 20060031956
    Abstract: The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or in a liver-specific manner. The invention further provides methods of using the regulatory nucleic acid sequences provided herein for age-related and/or liver-specific expression of nucleotides seuqences of interest. The invention also provides host cells and transgenic non-human animals which harbor the regulatory nucleic acid sequences of the invention. The compositions and methods of the invention are useful in regulating expression of a nucleotide sequence of interest in an age-related and/or liver-specific manner.
    Type: Application
    Filed: May 16, 2005
    Publication date: February 9, 2006
    Applicant: The Regents Of The University Of Michigan
    Inventors: Kotoku Kurachi, Sumiko Kurachi
  • Nucleotide sequences for gene regulation and methods of use thereof
    Patent number: 6610906
    Abstract: The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or in a liver-specific manner. The invention further provides methods of using the regulatory nucleic acid sequences provided herein for age-related and/or liver-specific expression of nucleotides sequences of interest. The invention also provides host cells and transgenic non-human animals which harbor the regulatory nucleic acid sequences of the invention. The compositions and methods of the invention are useful in regulating expression of a nucleotide sequence of interest in an age-related and/or liver-specific manner.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: August 26, 2003
    Assignee: The Regents of the University of Michigan
    Inventors: Kotoku Kurachi, Sumiko Kurachi
  • Method for enhancing myoblast migration and invasion in the context of gene therapy
    Publication number: 20010055590
    Abstract: A novel, empirically derived composition of cytokines and myoblasts is described, that allows for the migration of myoblasts through connective barriers, along with methods employing the composition in the in vivo migration of myoblasts for therapeutic purposes and gene therapy, as well as methods for the identification of agents that are agonistic or antagonistic to myoblast migration in vitro or in vivo.
    Type: Application
    Filed: August 6, 2001
    Publication date: December 27, 2001
    Inventor: Kotoku Kurachi
  • Method for enhancing myoblast migration and invasion in the context of gene therapy
    Patent number: 6284242
    Abstract: A novel, empirically derived composition of cytokines and myoblasts is described, that allows for the migration of myoblasts through connective barriers, along with methods employing the composition in the in vivo migration of myoblasts for therapeutic purposes and gene therapy, as well as methods for the identification of agents that are agonistic or antagonistic to myoblast migration in vitro or in vivo.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: September 4, 2001
    Assignee: Regents of the University of Michigan
    Inventor: Kotoku Kurachi
  • DNA sequences expressing mammalian .alpha..sub.1 -antitrypsin
    Patent number: 6025161
    Abstract: DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.This work was supported in part by grants HL16919 and HL27509 from the National Institutes of Health.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: February 15, 2000
    Assignee: Washington Research Foundation
    Inventors: Earl W. Davie, Kotoku Kurachi, Savio L. C. Woo, Chandra Thirumalachary
  • DNA sequences expressing mammalian .alpha..sub.1 antitrypsin
    Patent number: 5736379
    Abstract: DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.This work was supported in part by grants HL16919 and HL27509 from the National Institutes of Health.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Washington Research Foundation
    Inventors: Earl W. Davie, Kotoku Kurachi, Savio L. C. Woo, Chandra Thirumalachary
  • DNA sequences expressing mammalian alpha-1-antitrypsin
    Patent number: 5399684
    Abstract: DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: March 21, 1995
    Assignee: Washington Research Foundation
    Inventors: Earl W. Davie, Kotoku Kurachi, Savio L. C. Woo, Chandra Thirumalachary
  • DNA preparation of Christmas factor and use of DNA sequences
    Patent number: 4994371
    Abstract: There is disclosed an isolated DNA sequence and the amino acid sequence for human factor IX. The isolated DNA sequence and its flanking sequences are useful for determining mutations, deletions or other modifications in genetic sequences expressing normal factor IX or modifications thereof.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: February 19, 1991
    Inventors: Earl W. Davie, Kotoku Kurachi
  • CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
    Patent number: 4966849
    Abstract: DNA sequences encoding a protein having angiogenic activity and mutated DNA sequences encoding a protein having decreased angiogenic activity are disclosed. Expression vectors containing these wild-type or mutated sequences are introduced into host cells and direct the production of wild-type or mutant angiogenic proteins. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes. Mutant proteins produced according to the invention are useful therapeutic compositions as angiogensis inhibitors, which may retard tumor growth by inhibiting the development of a hemovascular network.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: October 30, 1990
    Assignee: President and Fellows of Harvard College
    Inventors: Bert L. Vallee, Kotoku Kurachi
  • CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression
    Patent number: 4916073
    Abstract: DNA sequences encoding a protein having angiogenic activity are disclosed. Expression vectors containing these sequences are introduced into host cells and direct the production of the angiogenic protein. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes.
    Type: Grant
    Filed: December 1, 1988
    Date of Patent: April 10, 1990
    Assignee: President and Fellows of Harvard College
    Inventors: Bert L. Vallee, Kotoku Kurachi
  • CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression
    Patent number: 4721672
    Abstract: DNA sequences encoding a protein having angiogenic activity are disclosed. Expression vectors containing these sequences are introduced into host cells and direct the production of the angiogenic protein. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnositic and therapeutic purposes.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: January 26, 1988
    Assignee: President and Fellows of Harvard College
    Inventors: Bert L. Vallee, Kotoku Kurachi