Patents by Inventor Kotomi Oda

Kotomi Oda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYNUCLEOTIDE CONSTRUCT CAPABLE OF DISPLAYING FAB IN A CELL-FREE TRANSLATION SYSTEM, AND METHOD FOR MANUFACTURING AND SCREENING FAB USING SAME
    Publication number: 20180017573
    Abstract: The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3?-end a structure necessary for maintaining a complex with the Fab encoded by itself; and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3?-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3?-end a structure necessary for maintaining
    Type: Application
    Filed: September 1, 2017
    Publication date: January 18, 2018
    Applicants: Mitsubishi Tanabe Pharma Corporation, The University of Tokyo
    Inventors: Yasuhiro FUJINO, Risako FUJITA, Kouichi WADA, Kotomi ODA, Takuya UEDA, Yoshihiro SHIMIZU, Takashi KANAMORI
  • Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same
    Patent number: 9753040
    Abstract: The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3?-end a structure necessary for maintaining a complex with the Fab encoded by itself; and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3?-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3?-end a structure necessary for maintaining
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: September 5, 2017
    Assignees: Mitsubishi Tanabe Pharma Corporation, The University of Tokyo
    Inventors: Yasuhiro Fujino, Risako Fujita, Kouichi Wada, Kotomi Oda, Takuya Ueda, Yoshihiro Shimizu, Takashi Kanamori
  • POLYNUCLEOTIDE CONSTRUCT CAPABLE OF DISPLAYING FAB IN A CELL-FREE TRANSLATION SYSTEM, AND METHOD FOR MANUFACTURING AND SCREENING FAB USING SAME
    Publication number: 20130288908
    Abstract: The polynucleotide construct of (1) or (2) below is used to perform ribosome display, CIS display and/or mRNA display in order to screen a Fab against an antigen of interest: (1) a polynucleotide construct which monocistronically comprises a ribosome-binding sequence, Fab first chain-coding sequence, linker peptide-coding sequence, Fab second chain-coding sequence and scaffold-coding sequence in this order, and further comprises at its 3?-end a structure necessary for maintaining a complex with the Fab encoded by itself, and (2) a polynucleotide construct which comprises a Fab first chain-expressing cistron and a Fab second chain-expressing cistron each containing a ribosome-binding sequence, a Fab first chain-coding sequence or Fab second chain-coding sequence, and a scaffold-coding sequence in this order, the first Fab-expressing cistron further comprising at its 3?-end a ribosome stall sequence, said Fab second chain-expressing cistron further comprising at its 3?-end a structure necessary for maintaining
    Type: Application
    Filed: November 30, 2011
    Publication date: October 31, 2013
    Applicants: THE UNIVERSITY OF TOKYO, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Yasuhiro Fujino, Risako Fujita, Kouichi Wada, Kotomi Oda, Takuya Ueda, Yoshihiro Shimizu, Takashi Kanamori
  • Phosphodiesterase and gene thereof
    Patent number: 8012731
    Abstract: The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39 in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: September 6, 2011
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Omori, Keizo Yuasa, Jun Kotera, Kotomi Oda, Hideo Michibata
  • NOVEL PHOSPHODIESTERASE AND GENE THEREOF
    Publication number: 20090325207
    Abstract: The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
    Type: Application
    Filed: December 20, 2007
    Publication date: December 31, 2009
    Applicant: MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Kenji OMORI, Keizo Yuasa, Jun Kotera, Kotomi Oda, Hideo Michibata
  • Phosphodiesterase and genes thereof
    Patent number: 7332317
    Abstract: The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39 in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 19, 2008
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Omori, Keizo Yuasa, Jun Kotera, Kotomi Oda, Hideo Michibata
  • Novel phosphodiesterase and genes thereof
    Publication number: 20030190672
    Abstract: The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a protein having an amino acid sequence shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39 in which one or several amino acids are deleted, substituted or added, and having an activity of hydrolyzing a cyclic nucleotide, and a gene thereof, and a method of characterizing, identifying and selecting a phosphodiesterase inhibitor by using the same.
    Type: Application
    Filed: June 21, 2002
    Publication date: October 9, 2003
    Inventors: Kenji Omori, Keizo Yuasa, Jun Kotera, Kotomi Oda, Hideo Michibata