Patents by Inventor Kou M. Hwang

Kou M. Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of infection by enveloped virus with calix(N)arene compounds
    Patent number: 5441983
    Abstract: A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachements to the ring, with polar substitutent having a terminal carboxylate, phosphate, or sulfonate groups, including esters and amides which are cleavable in vivo. The compound may be administered orally, or topically, e.g., for treatment of herpes virus.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: August 15, 1995
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu, William Choy, Jen Chen
  • Antithrombotic treatment with calix(n)arene compounds
    Patent number: 5409959
    Abstract: A method of inhibiting thrombus formation in a mammalian subject. The method involves administering to the subject a therapeutically effective dose of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having terminal sulfonate groups, including esters and amides which are cleavable in vivo.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: April 25, 1995
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu, Thomas C. Lee, William Choy, Jen Chen
  • Method of treating viral infections with aryl macrocyclic compounds
    Patent number: 5312837
    Abstract: A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a macrocyclic compound composed of aryl ring subunits connected one to another by ring-attached bridge linkages, and containing sulfonic acid-derived substituents carried on non-bridge atoms of the subunits.
    Type: Grant
    Filed: November 13, 1991
    Date of Patent: May 17, 1994
    Assignee: Genelabs Technologies, Inc.
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu
  • Macrocyclic anti-viral compound and method
    Patent number: 5196452
    Abstract: A compound and method for inhibiting cell infection by an enveloped virus. The compound is a macrocyclic chromotropic acid derivative which can be substituted at a variety of naphthalene ring and bridge positions. The compound may be administered parenterally, orally, or topically for treating infection by enveloped viruses.
    Type: Grant
    Filed: January 29, 1991
    Date of Patent: March 23, 1993
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu
  • Method of treating herpes simplex virus infection
    Patent number: 5166173
    Abstract: A method of inhibiting cell infection by herpes simplex virus-1 or -2. The method includes contacting the virus with a macrocyclic chromotropic acid compound, in an amount effective to inhibit cell infectivity of the virus.
    Type: Grant
    Filed: January 29, 1991
    Date of Patent: November 24, 1992
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu
  • Method of inhibiting HIV
    Patent number: 4795739
    Abstract: A method of inhibiting expression of HIV antigens in human blood cells infected with HIV. The infected cells are exposed to a plant protein or glycoprotein, such as trichosanthin or momorcharin, at a concentration sufficient to (a) produce a substantial reduction in the level of HIV antigen, and (b) effect a selective reduction in the number of HIV-infected cells, with respect to uninfected cells of the same type. The method is used to treat HIV infection in humans. In another aspect, the invention includes a method of screening drug agents effective in treating HIV infection in humans.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: January 3, 1989
    Assignees: Gene Labs, Inc., Regents of University of California
    Inventors: Jeffrey D. Lifson, Michael S. McGrath, Hin-Wing Yeung, Kou M. Hwang