Abstract: A method is provided for making a water soluble powdered formulation including a water-insoluble or difficultly-water-soluble chromogenic agent therein. The method includes first melting a water-soluble or water-miscible, heat-stable, polymeric material, e.g., PEG. The water-insoluble or difficultly-water-soluble chromogenic agent is then dissolved in such molten polymeric material. The molten polymeric material and the dissolved chromogenic agent are heated together for a predetermined period of time to provide a molten homogenate. The molten homogenate is then cooled to its solidification temperature to provide a solid homogenate. Finally, the cooled solid homogenate is pulverized to powdered form.

Abstract: A wound dressing is provided herein for systemic administration of a physiologically- or biologically-active agent by controlled release of the agent into such wound. The wound dressing includes a substrate in the form of a fabric or cloth, at least a portion of which is cellulosic, which has been chemically modified to convert hydroxyl groups in the cellulosic portion to ionic-adsorbing sites. An ionic form of a physiologically- or biologically-active agent, namely an antibacterial agent, an antifungal agent, an analgesic agent, a tissue healant agent, a local anesthetic agent, an antibleeding agent, an enzyme or a vasoconstrictor is adsorbed in that substrate. Ionic bonds hold that agent temporarily to the substrate for controlled release therefrom in proportion to the amount of exudate in contact with the substrate. The ionic bonds are formed by adsorbing that agent on that substrate at room temperature.

Abstract: Novel, highly useful, sweet fructose-containing syrups also containing fructooligosaccharides are provided herein by the partial or substantially complete hydrolysis of inulin. The process includes first providing an aqueous solution containing inulin from Jerusalem artichoke tubers or chicory roots. Then the warm aqueous solution of inulin is passed through a column containing a strong acid cation-exchange resin, thereby providing an effluent having a pH of about 2.0-about 3.0. The effluent is then hydrolyzed by heating at a temperature of about 70.degree.-about 100.degree. C., and the hydrolyzate is passed through a column containing of about 6.5-about 7.0. resin, thereby providing an effluent having a pH about 6.5-about 7.0. Optionally, after the hydrolysis step, the hydrolyzate is decolorized by contact with activated or granular charcoal. The effluent is then concentrated to a syrup containing less water than the effluent, e.g. one containing about 40-about 70% solids.