Patents by Inventor Kouhei NODU

Kouhei NODU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240309002
    Abstract: The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: or the like; y is 0 or 1; R1 is hydrogen or the like; R2a and R2b are taken together with an adjacent carbon atom to form ring B; ring B is a substituted or unsubstituted non-aromatic carbocycle or the like; R3a is hydrogen or the like; R3b is hydrogen or the like; R4a is represented by formula: L1 is a single bond or the like; L2 is —C(?O)— or the like; La is a single bond or the like; R7 is substituted or unsubstituted alkyl or the like; R4b is substituted or unsubstituted alkyl or the like; R4c is each independently halogen or the like.
    Type: Application
    Filed: May 16, 2024
    Publication date: September 19, 2024
    Applicant: Shionogi & Co., Ltd.
    Inventors: Kouhei NODU, Yusuke Tateno, Kengo Masuda, Yuji Nishiura, Yoshikazu Sasaki, Yu Hinata
  • Patent number: 12024519
    Abstract: The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: is or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: July 2, 2024
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Kouhei Nodu, Yusuke Tateno, Kengo Masuda, Yuji Nishiura, Yoshikazu Sasaki
  • Publication number: 20230382893
    Abstract: The present invention provides a compound represented by formula (I): wherein the dashed line indicates the presence or absence of a bond; R1 is carboxy or the like; L is substituted or unsubstituted non-aromatic carbocyclyldiyl or the like; R2 is substituted or unsubstituted alkyl; R3 is a hydrogen atom or the like; X is ?CRX— or ?N—; Y is ?CRY— or ?N—; U is —CRU? or —N?; V is —CRV? or —N?; W is ?CRW— or ?N—; ZA is —C? or —N—; ZB is —CR5R6— or the like; ZC is —CR7R8— or the like; RX, RY, RV and RW are each independently a hydrogen atom or the like; RU is a hydrogen atom or the like; R5 and R6 are each independently a hydrogen atom or the like; R7 and R8 are each independently a hydrogen atom or the like; R4 is substituted or unsubstituted alkyloxy or the like, or a pharmaceutically acceptable salt thereof, having an antiviral activity; and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: October 27, 2021
    Publication date: November 30, 2023
    Applicants: Shionogi & Co., Ltd., UBE Corporation
    Inventors: Azusa OKANO, Yusuke TATENO, Kouhei NODU, Shinji SUZUKI, Toshiyuki AKIYAMA, Masaaki MATOYAMA, Hirota AKAZA, Takashi FUKUDA
  • Publication number: 20220073518
    Abstract: The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.
    Type: Application
    Filed: November 12, 2021
    Publication date: March 10, 2022
    Applicant: Shionogi & Co., Ltd.
    Inventors: Kouhei NODU, Yusuke TATENO, Kengo MASUDA, Yuji NISHIURA, Yoshikazu SASAKI, Yu HINATA
  • Patent number: 11198695
    Abstract: The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: December 14, 2021
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Kouhei Nodu, Yusuke Tateno, Kengo Masuda, Yuji Nishiura, Yoshikazu Sasaki
  • Publication number: 20200291025
    Abstract: The present invention provides the compound represented by the following formula (I): wherein a moiety represented by formula: or the like. The symbols are defined in the specification. The compounds of the present invention have MGAT2 inhibitory activity, and are useful as a medicine for treatment of MGAT2-associated diseases including obesity, metabolic syndrome, hyperlipidemia, hypertriglyceridemia, hyper-VLDL-triglyceridemia, hyperfattyacidemia, diabetes mellitus, and arteriosclerosis.
    Type: Application
    Filed: July 13, 2018
    Publication date: September 17, 2020
    Applicant: Shionogi & Co., Ltd.
    Inventors: Kouhei NODU, Yusuke TATENO, Kengo MASUDA, Yuji NISHIURA, Yoshikazu SASAKI, Yu HINATA
  • Patent number: 10202404
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 12, 2019
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Tomokazu Yoshinaga, Kouhei Nodu
  • Publication number: 20180265525
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Applicant: Shionogi & Co., Ltd.
    Inventors: Tomokazu YOSHINAGA, Kouhei NODU
  • Patent number: 10011613
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: July 3, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Tomokazu Yoshinaga, Kouhei Nodu
  • Publication number: 20170226128
    Abstract: The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
    Type: Application
    Filed: August 21, 2015
    Publication date: August 10, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Tomokazu YOSHINAGA, Kouhei NODU