Patents by Inventor Kou-ichi Shiosaki

Kou-ichi Shiosaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purification of HBs antigen
    Patent number: 4738926
    Abstract: Industrially useful method for the purification of HBs antigen produced by a recombinant organism being capable of producing HBs antigen which is prepared by means of DNA recombination technique, which comprises subjecting an HBs antigen-containing material produced by a recombinant organism to an adsorption chromatography with a silica, optionally followed by a gel filtration and further an adsorption chromatography with a hydroxyapatite, and then eluting the HBs antigen, preferably, with a buffer having a pH 9 or more which is incorporated with urea. The purification method can give a highly pure HBs antigen suitable for the preparation of hepatitis B vaccine in a large scale from recombinant organisms prepared by DNA recombination technique.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: April 19, 1988
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Fukusaburo Hamada, Keishin Sugahara, Kou-ichi Shiosaki, Satoshi Adachi, Hiroshi Mizokami