Abstract: A metal cap in which a linear to be held to a cap body and separable from the cap body can be formed by a series of operations for forming the cap body and press molding the liner. The liner of the metal cap has a double-layer structure including a barrier layer on a top panel wall side and a sealing layer on the inner side of the cap body, and the barrier layer is temporarily bonded to the top panel wall with a weak adhesive at the time of molding the barrier layer and separated from the top panel wall by the natural cooling of the barrier layer after molding.

Abstract: A metal cap in which a linear to be held to a cap body and separable from the cap body can be formed by a series of operations for forming the cap body and press molding the liner. The liner of the metal cap has a double-layer structure including a barrier layer on a top panel wall side and a sealing layer on the inner side of the cap body, and the barrier layer is temporarily bonded to the top panel wall with a weak adhesive at the time of molding the barrier layer and separated from the top panel wall by the natural cooling of the barrier layer after molding.

Abstract: A metallic container closure including a shell of a thin metal sheet having a circular top panel wall (7) and a skirt wall (9), and a synthetic resin liner arranged in the shell, the skirt wall (9) having a thread-forming region and an annular groove (17) positioned at an upper end portion of the thread-forming region, wherein an internal pressure release line A extending in the circumferential direction is arranged in the skirt wall (9) at a portion over the annular groove (17), and annular bead (30) is arranged so as to pass through between the internal pressure release line A and the annular groove (17).

Abstract: The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.

Abstract: A metallic container closure comprising a shell of a thin metal sheet having a circular top panel wall 7 and a skirt wall 9, and a synthetic resin liner arranged in the shell, the skirt wall 9 having a thread-forming region and an annular groove 17 positioned at an upper end portion of the thread-forming region, wherein an internal pressure release line A extending in the circumferential direction is arranged in the skirt wall 9 at a portion over the annular groove 17, and annular bead 30 is arranged so as to pass through between the internal pressure release line A and the annular groove 17. The metallic container closure effectively releases the gas when the pressure in the container is elevated and effectively prevents the skirt wall from being deformed at a portion where the internal pressure release line A is formed when it is being wrap-seamed with the mouth-and-neck portion of the container.

Abstract: The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.

Abstract: A metallic container closure including a shell of a thin metal sheet having a circular top panel wall (7) and a skirt wall (9), and a synthetic resin liner arranged in the shell, the skirt wall (9) having a thread-forming region and an annular groove (17) positioned at an upper end portion of the thread-forming region, wherein an internal pressure release line A extending in the circumferential direction is arranged in the skirt wall (9) at a portion over the annular groove (17), and annular bead (30) is arranged so as to pass through between the internal pressure release line A and the annular groove (17).

Abstract: The problems of the present invention are to provide target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. The present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

Abstract: The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.

Abstract: The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.

Abstract: A metallic container closure comprising a shell of a thin metal sheet having a circular top panel wall 7 and a skirt wall 9, and a synthetic resin liner arranged in the shell, the skirt wall 9 having a thread-forming region and an annular groove 17 positioned at an upper end portion of the thread-forming region, wherein an internal pressure release line A extending in the circumferential direction is arranged in the skirt wall 9 at a portion over the annular groove 17, and annular bead 30 is arranged so as to pass through between the internal pressure release line A and the annular groove 17. The metallic container closure effectively releases the gas when the pressure in the container is elevated and effectively prevents the skirt wall from being deformed at a portion where the internal pressure release line A is formed when it is being wrap-seamed with the mouth-and-neck portion of the container.

Abstract: A method is provided in which an extremely small amount of a solution containing a substance to be analyzed can be analyzed with high throughput and without any loss of the solution. The method comprises the steps of introducing into a separation channel a first solution containing a substance that is eluted from the separation channel faster and a second solution containing a substance that is eluted from the separation channel more slowly, wherein at least a portion of the first solution is introduced into the separation channel after introducing at least a portion of the second solution thereinto, and detecting a chromatogram of the substances eluted from the separation channel.

Abstract: This invention relates to a method for fining a surface of a metal product to form crystal grains having sizes less than 1 ? m at their surfaces and the metal product produced thereby. The method is comprised of a process for forming crystal grains having sizes less than 1 ? m at the surface of the metal product by projecting or peening shots or projectiles while a power per unit of area of the surface, which power is caused by projecting or peening shots or projectiles, is controlled at a predetermined value.

Abstract: An improved acoustic characteristic adjustment device comprises signal processing units including high frequency convolution arithmetic sections, low frequency convolution arithmetic sections, and delay sections. The device further comprises: an operation section from which a listener inputs a target characteristic in order to adjust a desired acoustic characteristic; an impulse characteristic control section; and a delay time control section. The impulse characteristic control section calculates impulse response data to effect convolution arithmetics. The delay time control section calculates alignment delay times necessary for sounds emitted from the speakers to reach a listening position. The delay time control section also calculates correction times for compensating various phase deviations. Times obtained by correcting the alignment delay times with the correction times are set as the delay times of the delay sections, respectively.