Patents by Inventor Kouji Hattori

Kouji Hattori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190271636
    Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.
    Type: Application
    Filed: July 25, 2017
    Publication date: September 5, 2019
    Applicants: TOKUSHIMA UNIVERSITY, FUJIKIN INCORPORATED
    Inventors: Yoshihiro DEGUCHI, Takashi FUKAWA, Taiki HATTORI, Masaaki NAGASE, Kazuteru TANAKA, Kouji NISHINO, Nobukazu IKEDA
  • Patent number: 7928264
    Abstract: The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, —Z—R9 or (b), in which —Z— is —0—, —S—, R9 —SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: April 19, 2011
    Assignee: Astellas Pharma Inc.
    Inventors: Kouji Hattori, Susumu Toda, Kenichi Washizuka, Shinji Ito, Daisuke Tanabe, Takanobu Araki, Minoru Sakurai
  • Patent number: 7629366
    Abstract: The present invention relates to a compound formula [I]: wherein ?ect., X is bond, —CH2—, ?etc., Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: December 8, 2009
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kouji Hattori, Yasuyo Tomishima, Masashi Imanishi
  • Patent number: 7417060
    Abstract: The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: August 26, 2008
    Assignee: Astellas Pharma Inc.
    Inventors: Kouji Hattori, Susumu Toda, Masashi Imanishi, Shinji Ito, Kenichi Washizuka, Takanobu Araki, Minoru Sakurai, Daisuke Tanabe
  • Publication number: 20080039506
    Abstract: The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, —S—, R9—SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R?, in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.
    Type: Application
    Filed: September 20, 2005
    Publication date: February 14, 2008
    Applicant: Astellas Pharma Inc.
    Inventors: Kouji Hattori, Susumu Toda, Kenichi Washizuka, Shinji Ito, Daisuke Tanabe, Takanobu Araki, Minoru Sakurai
  • Publication number: 20070142638
    Abstract: Ornithine derivatives of the formula (I): wherein X is —CO— or —(CH2)k— (wherein k is 1, 2 or 3); Y is Z-(CH2)n—, and the like; {wherein Z is R1—CO—NR4—, and the like, (wherein R1 is aryl, and the like; and R4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R2 is aryl-(lower alkyl), and the like; R3 is -Q-R7, [wherein Q is —CO— or —SO2—, R is heterocyclyl], and the like; and R5 and R6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 21, 2007
    Applicant: Astellas Pharma Inc.
    Inventors: Kouji Hattori, Naoaki Fujii, Akira Tanaka, Kenichi Washizuka, Minoru Sakurai
  • Patent number: 7162911
    Abstract: Electrical characteristics of a semiconductor acceleration sensor containing a switched capacitor filter (15) are tested while the semiconductor acceleration sensor (1, 30, 50, 70, 90) is vibrated to apply a predetermined acceleration to the semiconductor acceleration sensor (1, 30, 50, 70, 90). The vibration frequency is fixed to a low frequency (for example, 50 Hz) at which the acceleration can be stably applied, and the characteristic of LPF is varied to plural kinds by a signal from an external testing apparatus (2, 40, 60, 80, 95). A sensor signal is received under each of the plural filter characteristics, and if these are within a predetermined specific range, the semiconductor acceleration sensor (1, 30, 50, 70, 90) is judged to be normal.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: January 16, 2007
    Assignee: Denso Corporation
    Inventor: Kouji Hattori
  • Publication number: 20060100252
    Abstract: The present invention relates to a compound formula [I]: wherein ect., X is bond, —CH2—, etc., Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Application
    Filed: December 16, 2005
    Publication date: May 11, 2006
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Kouji Hattori, Yasuyo Tomishima, Masashi Imanishi
  • Patent number: 7037938
    Abstract: The present invention relates to a compound formula [I]: wherein Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: May 2, 2006
    Assignee: Astellas Pharma Inc.
    Inventors: Kouji Hattori, Yasuyo Tomishima, Masashi Imanishi
  • Publication number: 20050171101
    Abstract: A compound of the formula (I): wherein ring A is a carbocyclic group, R1 is hydrogen or a halogen atom or a lower alkyl group, R2 is a di(lower)alkylamino group or N-containing heterocyclic group, among which the N-containing heterocyclic group may be substituted with one or more substituent(s), Y is an oxygen or sulfur atom, n is an integer from 0 to 2, and m is an integer from 0 to 4, or its prodrug, or their salt which has poly(adenosine 5?-diphospho-ribose)polymerase inhibiting activity.
    Type: Application
    Filed: March 25, 2003
    Publication date: August 4, 2005
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Hirofumi Yamamoto, Koichiro Mukoyoshi, Kouji Hattori
  • Publication number: 20050137236
    Abstract: The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Application
    Filed: December 21, 2004
    Publication date: June 23, 2005
    Applicant: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kouji Hattori, Susumu Toda, Masashi Imanishi, Shinji Ito, Kenichi Washizuka, Takanobu Araki, Minoru Sakurai, Daisuke Tanabe
  • Publication number: 20050090669
    Abstract: The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond, -o-o, —O—CH2—, etc., y is in which Z is bond, —O—(CH2)m— (in which m is 1 to 4), etc., R3 is lower alkanoyl, carboxy, lower alkoxycarbonyl, etc., and R4 is hydrogen, halogen, hydroxy, phenoxy, lower alkyl, lower alkoxy, etc., and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
    Type: Application
    Filed: March 10, 2003
    Publication date: April 28, 2005
    Inventors: Kouji Hattori, Yasuyo Tomishima, Yutaka Nakajima, Masashi Imanishi
  • Publication number: 20050080096
    Abstract: A condensed heterocyclic compound having poly(adenosine 5?-diphospho-ribose)polymerase (PARP) inhibitory activity by the formula (I): wherein R1 is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, pyridine ring, etc, —Y1?Y2— is formula (II) wherein L11, L12, L13 and L14 is (1) lower alkylene, (2) lower alkenylene, etc, and R21, R22, R23 and R24 is (1) cyclic amino group, which is substituted with phenyl optionally substituted with one or more suitable substituent(s), etc. provided that when A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, then —Y1?Y2— is formula (III) or its prodrug, or their salts.
    Type: Application
    Filed: January 27, 2003
    Publication date: April 14, 2005
    Inventors: Junya Ishida, Kouji Hattori, Yoshiyuki Kido, Hirofumi Yamamoto
  • Publication number: 20050043333
    Abstract: A quinazolinone derivatives having poly (adenosine 5?-diphospho-ribose) polymerase (PARP) inhibitory activity represented by the formula (I): wherein R1 is substituted cyclic amino groups or optionally substituted amino group, R2 is substituent, n means an integer of 0 to 4, and L1 is (1) cyclo (lower) alkylene, (2) cyclo (lower) alkenylene, (3) diradical of saturated- or unsaturated monocyclic group with one or more nitrogen atom(s), which is obtained after removal of one hydrogen atom from said monocyclic group, or (4) —N(R3)—L2— (wherein R3 is hydrogen or lower alkyl, and L2 is lower alkylene or lower alkenylene), or its prodrug, or a salt thereof.
    Type: Application
    Filed: December 19, 2002
    Publication date: February 24, 2005
    Applicant: Fujisawa Pharmaceutical Co., Ltd
    Inventors: Junya Ishida, Kouji Hattori, Yoshiyuki Kido
  • Publication number: 20040255673
    Abstract: Electrical characteristics of a semiconductor acceleration sensor containing a switched capacitor filter (15) are tested while the semiconductor acceleration sensor (1, 30, 50, 70, 90) is vibrated to apply a predetermined acceleration to the semiconductor acceleration sensor (1, 30, 50, 70, 90). The vibration frequency is fixed to a low frequency (for example, 50 Hz) at which the acceleration can be stably applied, and the characteristic of LPF is varied to plural kinds by a signal from an external testing apparatus (2, 40, 60, 80, 95). A sensor signal is received under each of the plural filter characteristics, and if these are within a predetermined specific range, the semiconductor acceleration sensor (1, 30, 50, 70, 90) is judged to be normal.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 23, 2004
    Applicant: DENSO CORPORATION
    Inventor: Kouji Hattori
  • Publication number: 20040106653
    Abstract: The present invention relates to a compound formula [I]: 1
    Type: Application
    Filed: November 20, 2003
    Publication date: June 3, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Minoru Sakurai, Hitoshi Hamashima, Kouji Hattori
  • Publication number: 20040077667
    Abstract: A quinazolinone derivatives having poly (adenosine 5′-diphaspho-ribose)polymerase (PARP) inhibotory activity represented by the formula (I), wherein R1 is optionally substituted cyclic amino groups or optionally substituted amino group, R2 is substituent, n means an integer from 0 to 4, and L is lower akkylene or lower alkenylene, or its prodrug, or their salts.
    Type: Application
    Filed: June 9, 2003
    Publication date: April 22, 2004
    Inventors: Nobuya Matsuoka, Akinori Iwashita, Shunji Yamazaki, Hiroshi Miyake, Mitsuru Ohkubo, Kazunori Kamijo, Isao Nakanishi, Kenji Murano, Kouji Hattori, Yoshiyuki Kido, Junya Ishida, Hirofumi Yamamoto
  • Publication number: 20040006143
    Abstract: The present invention relates to a compound formula [I]: 1
    Type: Application
    Filed: June 26, 2003
    Publication date: January 8, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Kouji Hattori, Yasuyo Tomishima, Masashi Imanishi
  • Patent number: 6660759
    Abstract: Heterocyclic compounds of formula (I), wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable sustituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, (a) is (b), etc., —A3— is (c), etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: December 9, 2003
    Assignee: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Kouji Hattori, Akira Tanaka
  • Patent number: 6437146
    Abstract: Oxazole compounds of formula (I), wherein R1 is aryl which may be substituted with halogen(s), R2 is aryl which may be substituted with halogen(s), X is single bond, (a) or SO2, R3 and R4 are independently hydrogen or suitable substituent, (wherein X is (a), neither R3 nor R4 is hydrogen), R3 and R4 may be linked together to form (b), (b) is N-containing heterocyclic group which may be substituted with one or more suitable substituent(s), R5 is hydrogen, etc., A1 is lower alkylene or single bond, (c) is cyclo(C3-C9)alkane or cyclo(C5-C9)alkene, or a pro-drug thereof, or a pharmaceutically acceptable salt thereof, which are useful as medicament.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: August 20, 2002
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kouji Hattori, Akira Tanaka, Yutaka Kono, Shoko Nakazato