Patents by Inventor Kousuke Horita

Kousuke Horita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING VACCINIA VIRUS EXPRESSING FOREIGN GENE
    Publication number: 20190367886
    Abstract: The present invention has an object to provide a vaccinia virus expressing a foreign gene and capable of killing cancer cells, and a cancer therapy drug comprising the vaccinia virus. The present invention relates to a vaccinia virus, wherein a suicide gene as a foreign gene selected from the group consisting of cytosine deaminase (CD) gene, uracil phosphoribosyltransferase (UPRT) gene, and herpes simplex virus thymidine kinase (HSV-tk) gene is introduced.
    Type: Application
    Filed: July 13, 2017
    Publication date: December 5, 2019
    Applicant: National University Corporation Tottori Tottori University
    Inventors: Takafumi Nakamura, Motomu Nakatake, Hajime Kurosaki, Kousuke Horita
  • Host regulatory factor that enhances replication and/or propagation of vaccinia virus
    Patent number: 10370647
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: August 6, 2019
    Assignee: National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
  • HOST REGULATORY FACTOR THAT ENHANCES REPLICATION AND/OR PROPAGATION OF VACCINIA VIRUS
    Publication number: 20180208904
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Application
    Filed: July 22, 2016
    Publication date: July 26, 2018
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake