Patents by Inventor Kousuke Niwa
Kousuke Niwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10822292Abstract: A method for producing a reaction product, with which the reaction product is obtained from a starting material through a particular organic synthesis reaction, the method includes (a) a step of setting a target wavelength to a peak wavelength of a reaction region involved in the organic synthesis reaction in an infrared absorption spectrum of the starting material; (b) a step of preparing an infrared heater that emits an infrared ray having a peak at the target wavelength from a structure constituted by a metal pattern, a dielectric layer, and a metal substrate stacked in this order from an outer side toward an inner side; and (c) a step of obtaining the reaction product by allowing the organic synthesis reaction to proceed while the infrared ray having a peak at the target wavelength is being applied to the starting material from the infrared heater.Type: GrantFiled: January 23, 2019Date of Patent: November 3, 2020Assignee: NGK Insulators, Ltd.Inventors: Kousuke Niwa, Yoshio Kondo, Hiroaki Isobe, Michiro Aoki
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Patent number: 10720746Abstract: An optical element includes an optical waveguide layer. The optical waveguide includes a periodic structure of grooves. The optical waveguide layer has a layer-thickness equal to or greater than 1.5 ?m and is made of material selected from a group consisting of Ta2O5, Al2O3, LiNbO3, LiTaO3, AlN, GaN, SiC, and Yttrium aluminum garnet (YAG). (D/0.5?)?2.5 is satisfied where D indicates the depth of groove; and ? indicates the pitch of the arranged grooves in the periodic structure. The unit of ? is identical to the unit of D.Type: GrantFiled: May 31, 2019Date of Patent: July 21, 2020Assignee: NGK Insulators, Ltd.Inventors: Kousuke Niwa, Jungo Kondou, Shoichiro Yamaguchi, Keiichiro Asai
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Patent number: 10703697Abstract: An organic compound refinement method for refining a specific organic compound which is a target compound from at least two types of organic compounds. The method includes separating the target compound from an organic compound other than the target compound while the at least two types of organic compounds are irradiated with light at an infrared absorption wavelength of a specific functional group that is not contained in the target compound but is contained in the organic compound other than the target compound, or separating the target compound from an organic compound other than the target compound while the at least two types of organic compounds are irradiated with light at an infrared absorption wavelength of a specific functional group that is contained in the target compound but is not contained in the organic compound other than the target compound.Type: GrantFiled: February 14, 2019Date of Patent: July 7, 2020Assignee: NGK Insulators, Ltd.Inventors: Kousuke Niwa, Hiroaki Isobe
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Publication number: 20190288473Abstract: An optical element includes an optical waveguide layer. The optical waveguide includes a periodic structure of grooves. The optical waveguide layer has a layer-thickness equal to or greater than 1.5 ?m and is made of material selected from a group consisting of Ta2O5, Al2O3, LiNbO3, LiTaO3, AlN, GaN, SiC, and Yttrium aluminum garnet (YAG). (D/0.5?)?2.5 is satisfied where D indicates the depth of groove; and ? indicates the pitch of the arranged grooves in the periodic structure. The unit of ? is identical to the unit of D.Type: ApplicationFiled: May 31, 2019Publication date: September 19, 2019Applicant: NGK INSULATORS, LTD.Inventors: Kousuke NIWA, Jungo KONDOU, Shoichiro YAMAGUCHI, Keiichiro ASAI
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Publication number: 20190194101Abstract: An organic compound refinement method for refining a specific organic compound which is a target compound from at least two types of organic compounds. The method includes separating the target compound from an organic compound other than the target compound while the at least two types of organic compounds are irradiated with light at an infrared absorption wavelength of a specific functional group that is not contained in the target compound but is contained in the organic compound other than the target compound, or separating the target compound from an organic compound other than the target compound while the at least two types of organic compounds are irradiated with light at an infrared absorption wavelength of a specific functional group that is contained in the target compound but is not contained in the organic compound other than the target compound.Type: ApplicationFiled: February 14, 2019Publication date: June 27, 2019Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Hiroaki Isobe
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Publication number: 20190152881Abstract: A method for producing a reaction product, with which the reaction product is obtained from a starting material through a particular organic synthesis reaction, the method includes (a) a step of setting a target wavelength to a peak wavelength of a reaction region involved in the organic synthesis reaction in an infrared absorption spectrum of the starting material; (b) a step of preparing an infrared heater that emits an infrared ray having a peak at the target wavelength from a structure constituted by a metal pattern, a dielectric layer, and a metal substrate stacked in this order from an outer side toward an inner side; and (c) a step of obtaining the reaction product by allowing the organic synthesis reaction to proceed while the infrared ray having a peak at the target wavelength is being applied to the starting material from the infrared heater.Type: ApplicationFiled: January 23, 2019Publication date: May 23, 2019Applicant: NGK INSULATORS, LTD.Inventors: Kousuke NIWA, Yoshio KONDO, Hiroaki ISOBE, Michiro AOKI
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Publication number: 20180119211Abstract: The disclosure of the present description provides a method for detecting a target nucleic acid, whereby probe hybridization can be accomplished efficiently. To that end, a target nucleic acid is amplified using a first primer having a tag sequence complementary to a detection probe pre-associated with the target nucleic acid and a first recognition sequence that recognizes a first base sequence in the target nucleic acid and also having a linking site capable of inhibiting or arresting a DNA polymerase reaction disposed between the tag sequence and the first recognition sequence, and a second primer having a second recognition sequence that recognizes a second base sequence in the target nucleic acid, the amplified fragment is brought into contact with a detection probe so as to allow hybridization, and the hybridization product is detected.Type: ApplicationFiled: November 22, 2017Publication date: May 3, 2018Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Toshikazu Hirota, Mitsuo Kawase
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Publication number: 20170363785Abstract: A grating device includes a supporting body having a first main face and a second main face, an under clad layer provided on the first main face of the supporting body, an optical material layer provided on the under clad layer, and a back face layer provided on the second main face of the supporting body. The under clad layer is composed of g a material having a refractive index of 1.69 or lower. The optical material layer is composed of a metal oxide having a refractive index of 1.70 or higher and 3.50 or lower and includes a Bragg grating. The back face layer is composed of a material having a refractive index of 1.69 or lower or a metal oxide having a refractive index of 1.70 or higher and 3.50 or lower.Type: ApplicationFiled: September 6, 2017Publication date: December 21, 2017Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Keiichiro Asai, Shoichiro Yamaguchi, Jungo Kondo
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Publication number: 20170343708Abstract: It is provided an assembly including an optical material layer composed of a metal oxide, an underlying layer provided over the optical material layer and composed of a metal or a metal silicide, and a resin layer provided over the underlying layer. A mold including a design pattern corresponding with the fine pattern to the resin layer of the assembly to transcript the design pattern to the resin layer. The resin layer and underlying layer are etched to form an opening in the resin layer and underlying layer to expose the optical material layer through the opening. The optical material layer is etched using the underlying layer as a mask to form the fine pattern in the optical material layer.Type: ApplicationFiled: August 15, 2017Publication date: November 30, 2017Applicant: NGK INSULATORS, LTD.Inventors: Kousuke NIWA, Keiichiro ASAI, Shoichiro YAMAGUCHI, Jungo KONDO
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Publication number: 20170306393Abstract: The disclosure of this Description includes: a step of preparing a solid-phase body provided with a detection probe having a predetermined nucleotide sequence; a step of preparing a signaling target nucleic acid having a signal generating part for detecting the target nucleic acid; a step of bringing the signaling target nucleic acid, the detection probe, and an oligonucleotide being a mediator having a first site that hybridizes specifically with the target nucleic acid and a second site (preferably 20 to 50 nucleotides or more preferably 20 to 25 nucleotides in length) that hybridizes specifically with a part having the predetermined nucleotide sequence of the detection probe into contact with one another so that a hybridization product of these components can be formed; and a step of obtaining data based on the signal generating part of the signaling target nucleic acid on the solid-phase body.Type: ApplicationFiled: September 4, 2014Publication date: October 26, 2017Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Toshikazu Hirota
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Publication number: 20160032367Abstract: An object of the disclosure of the present specification is to provide a method for detection of a target nucleic acid which allows construction of an effective detection system of a target nucleic acid. For this purpose, in the disclosure of the present specification, a first primer comprising an identification sequence complementary to a target sequence in a target nucleic acid and a tag addition sequence, and a second primer having a label are prepared. The first primer and the second primer are used for the target nucleic acid in a sample to amplify a chimeric DNA having a tag sequence and the label. The chimeric DNA is hybridized with a detection probe on a solid phase to obtain signal intensity information based on the label, and the target nucleic acid is detected based on the signal intensity information.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Applicant: NGK INSULATORS, LTD.Inventors: Mitsuo Kawase, Toshikazu Hirota, Kousuke Niwa
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Patent number: 9175339Abstract: An object of the disclosure of the present specification is to provide a method for detection of a target nucleic acid which allows construction of an effective detection system of a target nucleic acid. For this purpose, in the disclosure of the present specification, a first primer comprising an identification sequence complementary to a target sequence in a target nucleic acid and a tag addition sequence, and a second primer having a label are prepared. The first primer and the second primer are used for the target nucleic acid in a sample to amplify a chimeric DNA having a tag sequence and the label. The chimeric DNA is hybridized with a detection probe on a solid phase to obtain signal intensity information based on the label, and the target nucleic acid is detected based on the signal intensity information.Type: GrantFiled: October 26, 2010Date of Patent: November 3, 2015Assignee: NGK Insulators, Ltd.Inventors: Mitsuo Kawase, Toshikazu Hirota, Kousuke Niwa
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Publication number: 20150125859Abstract: Provided is a nucleic acid chromatography method ensuring a stable detection state, and a composition and kit for use in nucleic acid chromatography. For this purpose, the nucleic acid chromatography method is provided with a step of performing chromatography by supplying a chromatography liquid containing a target nucleic acid to a solid-phase carrier on which is fixed a detection probe capable of capturing the nucleic acid, wherein the chromatography liquid contains one or two or more kinds of water-soluble polymers.Type: ApplicationFiled: December 31, 2014Publication date: May 7, 2015Applicant: NGK INSULATORS, LTD.Inventors: Akinobu Oribe, Kousuke Niwa, Toshikazu Hirota
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Publication number: 20150111774Abstract: The disclosure of this Description includes: a step of preparing a solid-phase body provided with a detection probe having a predetermined nucleotide sequence; a step of preparing a signaling target nucleic acid having a signal generating part for detecting the target nucleic acid; a step of bringing the signaling target nucleic acid, the detection probe, and an oligonucleotide being a mediator having a first site that hybridizes specifically with the target nucleic acid and a second site (preferably 20 to 50 nucleotides or more preferably 20 to 25 nucleotides in length) that hybridizes specifically with a part having the predetermined nucleotide sequence of the detection probe into contact with one another so that a hybridization product of these components can be formed; and a step of obtaining data based on the signal generating part of the signaling target nucleic acid on the solid-phase body.Type: ApplicationFiled: September 4, 2014Publication date: April 23, 2015Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Toshikazu Hirota
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Publication number: 20140206567Abstract: The disclosure of the present description provides a method for detecting a target nucleic acid, whereby probe hybridization can be accomplished efficiently. To that end, a target nucleic acid is amplified using a first primer having a tag sequence complementary to a detection probe pre-associated with the target nucleic acid and a first recognition sequence that recognizes a first base sequence in the target nucleic acid and also having a linking site capable of inhibiting or arresting a DNA polymerase reaction disposed between the tag sequence and the first recognition sequence, and a second primer having a second recognition sequence that recognizes a second base sequence in the target nucleic acid, the amplified fragment is brought into contact with a detection probe so as to allow hybridization, and the hybridization product is detected.Type: ApplicationFiled: March 13, 2014Publication date: July 24, 2014Applicant: NGK INSULATORS, LTD.Inventors: Kousuke Niwa, Toshikazu Hirota, Mitsuo Kawase
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Publication number: 20130115718Abstract: Disclosed are a carrier that carries identifying information having favorable identification performance and a use thereof. The carrier carries identifying information for identifying an identification subject, and comprises one or more pieces of DNA having a thymine-rich base sequence and having, as the identifying information, an identifying base sequence pre-associated with the identification subject.Type: ApplicationFiled: July 15, 2011Publication date: May 9, 2013Applicant: NGK INSULATORS, LTD.Inventors: Toshikazu Hirota, Kousuke Niwa
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Publication number: 20120196765Abstract: A method of detecting or analyzing a target sequence in a genomic DNA by using a capture probe immobilized on a solid carrier includes: bringing the target nucleic acid into contact with a first query probe that has a sequence complementary to a portion of the target sequence or to a sequence adjacent to the portion and a second query probe that has a sequence complementary to another portion of the target sequence or to a sequence adjacent to the another portion and that has a recognition sequence complementary to a portion of the capture probe; acquiring a ligated molecule by ligating the first query probe and the second query probe that are hybridized to the target nucleic acid; bringing the ligated molecule into contact with the capture probe on the solid carrier and then capturing the ligated molecule on the solid carrier by hybridizing the capture probe with the recognition sequence in the ligated molecule; and detecting the captured ligated molecule.Type: ApplicationFiled: July 9, 2010Publication date: August 2, 2012Inventors: Mitsuo Kawase, Toshikazu Hirota, Kousuke Niwa
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Publication number: 20120178648Abstract: An object of the disclosure of the present specification is to provide a method for detection of a target nucleic acid which allows construction of an effective detection system of a target nucleic acid. For this purpose, in the disclosure of the present specification, a first primer comprising an identification sequence complementary to a target sequence in a target nucleic acid and a tag addition sequence, and a second primer having a label are prepared. The first primer and the second primer are used for the target nucleic acid in a sample to amplify a chimeric DNA having a tag sequence and the label. The chimeric DNA is hybridized with a detection probe on a solid phase to obtain signal intensity information based on the label, and the target nucleic acid is detected based on the signal intensity information.Type: ApplicationFiled: October 26, 2010Publication date: July 12, 2012Inventors: Mitsuo Kawase, Toshikazu Hirota, Kousuke Niwa
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Publication number: 20110229980Abstract: The present teaching provides a fluorescent oligonucleotide probe having a high degree of design flexibility and wide applicability, as well as the use thereof. This is an oligonucleotide probe capable of forming a stem and loop, comprising at least one fluorophore located between adjacent nucleotides in the stem and is linked to a unit represented by Formula (1) and at least one quencher located at a site capable of pairing up with the at least one fluorophore located between the adjacent nucleotides in the stem and is linked to a unit represented by Formula (2). (In the formulae, X represents the fluorophore, Y represents the quencher, R1 represents an optionally substituted C2 or C3 alkylene chain, R2 represents an optionally substituted C0-2 alkylene chain, and Z represents a direct bond or linker.Type: ApplicationFiled: December 31, 2010Publication date: September 22, 2011Applicants: National University Corporation Nagoya University, NGK Insulators, Ltd.Inventors: Hiroyuki ASANUMA, Xingguo Liang, Hiromu Kashida, Yasuko Yoshida, Tomokazu Takase, Kousuke Niwa
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Publication number: 20100276309Abstract: In a state where liquids are contained in a plurality of liquid container portions which are formed in a first layer and a second layer of a cartridge and which have predetermined volumes determined depending on liquids to be contained, and where the reaction vessel is connected to any one of communicating ports, when pressure is applied to act upon one of the liquid container portions which is communicated with the communicating port connected to the reaction vessel, the atmosphere is supplied to the one liquid container portion through a atmosphere flowing passage communicating with the outside, and the liquid contained in the one liquid container portion is supplied to the reaction vessel. The cartridge is rotated to connect another communicating port to the reaction vessel such that plural liquids are eventually supplied to the reaction vessel.Type: ApplicationFiled: December 12, 2008Publication date: November 4, 2010Inventors: Masahiro Murasato, Kazunari Yamada, Dai Yamamoto, Akinobu Oribe, Kousuke Niwa