Patents by Inventor Koutoku Aihara
Koutoku Aihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5925640Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: July 20, 1999Assignee: Otsuka Pharmaceutical Co. Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5916890Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: June 29, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5872120Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: February 16, 1999Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5798358Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: May 9, 1997Date of Patent: August 25, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5756675Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.Type: GrantFiled: June 6, 1994Date of Patent: May 26, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikatsu Hirai, Satoru Nakai, Koutoku Aihara, Kazuyoshi Kawai, Mayumi Kaneta, Takashi Kamogashira, Yoshihiro Masui
-
Patent number: 5750529Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: May 12, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5691341Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: August 29, 1995Date of Patent: November 25, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
-
Patent number: 5672603Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: September 30, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5658912Abstract: An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5543412Abstract: An object of the invention is to provide hepatitis therapy. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: August 6, 1996Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
-
Patent number: 5464833Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.Type: GrantFiled: April 19, 1994Date of Patent: November 7, 1995Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
-
Patent number: 5120534Abstract: The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.Type: GrantFiled: July 28, 1989Date of Patent: June 9, 1992Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikatsu Hirai, Satoru Nakai, Koutoku Aihara, Kazuyoshi Kawai, Mayumi Kaneta, Takashi Kamogashira, Yoshihiro Masui