Patents by Inventor Kozo Nagaoka

Kozo Nagaoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-piperidinecarboxylic acid derivative, oncogene suppressor and agent for obtaining revertants
    Patent number: 5334723
    Abstract: A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: August 2, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tsuneo Okonogi, Osamu Makabe, Yuichi Yamamoto, Osamu Itoh, Tsutomu Tsuruoka, Takayuki Usui, Seiji Shibahara, Kozo Nagaoka, Shigeharu Inouye, Nobuko Okada, Susumu Nishimura
  • Megakaryocyte colony stimulating factor and process for its preparation
    Patent number: 5258324
    Abstract: A novel megakaryocyte colony stimulating factor has been isolated from the supernatant of the culture obtained by cultivating a cell strain of a human large cell lung cancer. When the factor is applied to human or murine bone-marrow cells in vitro, it forms a megakaryocyte colony. Also, the factor increases the number of platelets in peripheral blood in vivo.
    Type: Grant
    Filed: March 20, 1991
    Date of Patent: November 2, 1993
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keita Matsunaga, Shinichiro Kuriya, Kiyoyuki Ogata, Hiroyuki Hamaguchi, Chuhei Nojiri, Osamu Makabe, Takeo Nomura, Kozo Nagaoka
  • Gene coding for signal peptides and utilization thereof
    Patent number: 4783415
    Abstract: A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: November 8, 1988
    Assignee: Meiji Seika Kabushiki Kaisha
    Inventors: Shigeru Hoshiko, Osamu Makabe, Shunzo Fukatsu, Kozo Nagaoka
  • Derivatives of streptomycin and method of producing streptomycin derivatives by mutational biosynthesis
    Patent number: 3993544
    Abstract: A method of making new derivatives of streptomycin by mutational biosynthesis. A mutant of Streptomyces griseus makes streptomycin production dependent on streptidine addition.A new antibiotic, deoxystreptomycin, is disclosed.
    Type: Grant
    Filed: September 26, 1975
    Date of Patent: November 23, 1976
    Assignee: Massachusetts Institute of Technology
    Inventors: Arnold L. Demain, Kozo Nagaoka
  • 2-Deoxystreptomycin
    Patent number: 3956275
    Abstract: A method of making new derivatives of streptomycin by mutational biosynthesis. A mutant of Streptomyces griseus makes streptomycin production dependent on streptidine addition.A new antibiotic, deoxystreptomycin, is disclosed.
    Type: Grant
    Filed: January 20, 1975
    Date of Patent: May 11, 1976
    Assignee: Massachusetts Institute of Technology
    Inventors: Arnold L. Demain, Kozo Nagaoka