Abstract: Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.

Abstract: Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.

Abstract: A dynamic Raman signal acquisition apparatus, system, and method involving: an excitation light source operable at a designated irradiation power and for a designated acquisition time for each Raman data acquisition; a Raman probe operatively associated with said excitation light source to irradiate the biological tissue at said designated irradiation power and for said designated acquisition time, and capture an optical Raman response therefrom; a spectrometer operable to spectrally analyze said optical Raman response; and a controller in operative communication with said excitation light source and said spectrometer to automatically adjust at least one signal acquisition parameter.

Abstract: Described are various embodiments of a dynamic Raman signal acquisition system, method and apparatus. In one embodiment, a Raman system comprises: an excitation light source operable at a designated irradiation power and for a designated acquisition time for each Raman data acquisition; a Raman probe operatively associated with said excitation light source to irradiate the biological tissue at said designated irradiation power and for said designated acquisition time, and capture an optical Raman response therefrom; a spectrometer operable to spectrally analyze said optical Raman response; and a controller in operative communication with said excitation light source and said spectrometer to automatically adjust at least one signal acquisition parameter.

Abstract: Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.