Patents by Inventor Krina PATEL

Krina PATEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of alkaline washes during chromatography to remove impurities
    Patent number: 12157073
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: December 3, 2024
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20220072041
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: July 9, 2021
    Publication date: March 10, 2022
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL
  • USE OF ALKALINE WASHES DURING CHROMATOGRAPHY TO REMOVE IMPURITIES
    Publication number: 20200282332
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • Use of alkaline washes during chromatography to remove impurities
    Patent number: 10695693
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: June 30, 2020
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • USE OF ALKALINE WASHES DURING CHROMATOGRAPHY TO REMOVE IMPURITIES
    Publication number: 20180078876
    Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.
    Type: Application
    Filed: March 11, 2016
    Publication date: March 22, 2018
    Inventors: Jue Wang, Neil E. Jaffe, Krina Patel
  • GENE MODIFIED IMMUNE EFFECTOR CELLS AND ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
    Publication number: 20170333480
    Abstract: Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Inventors: Laurence J.N. COOPER, Harjeet SINGH, Helen HULS, Simon OLIVARES, Bipulendu JENA, Krina PATEL