Patents by Inventor Kris Buchanan
Kris Buchanan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230384201Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbilng a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: ApplicationFiled: April 27, 2023Publication date: November 30, 2023Applicant: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 11668640Abstract: A method of sorting cells including magnetically coupling a nozzle assembly to a flow cytometer in a predetermined orientation to form a fluid stream having a sheath fluid and a sample fluid. Particles within the sample fluid are oriented and then interrogated at an inspection zone to produces signals representative of emitted or reflected electromagnetic radiation. The electromagnetic radiation is analyzed to classify the cells and the cells are sorted according to their classification.Type: GrantFiled: March 26, 2020Date of Patent: June 6, 2023Assignee: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 10850276Abstract: Systems and methods that enable the rapid identification of target molecules present in a sample at low concentrations is provided. The system includes a sample volume, and a detection structure that is connected to the sample volume by a conduit. The detection structure includes a microfluidic chip that defines a plurality of fluid channels. The walls of the fluid channels are formed from or covered with a metal oxide to which target molecules attach. After the sample volume has been passed through the detection structure, and in particular through the channels, visible microparticles are passed through the detection structure. The visible microparticles are configured to have an affinity for the target molecules. The microfluidic chip is then imaged to detect visible microparticles, and to thereby obtain information regarding the presence of the target molecules.Type: GrantFiled: February 26, 2018Date of Patent: December 1, 2020Assignee: VISUGEN GLOBAL LLCInventors: John C. Gerdes, Kirsten L. Nelson, Kris Buchanan
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Publication number: 20200271564Abstract: A method of sorting cells including magnetically coupling a nozzle assembly to a flow cytometer in a predetermined orientation to form a fluid stream having a sheath fluid and a sample fluid. Particles within the sample fluid are oriented and then interrogated at an inspection zone to produces signals representative of emitted or reflected electromagnetic radiation. The electromagnetic radiation is analyzed to classify the cells and the cells are sorted according to their classification.Type: ApplicationFiled: March 26, 2020Publication date: August 27, 2020Applicant: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 10634601Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: GrantFiled: March 14, 2013Date of Patent: April 28, 2020Assignee: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 10371622Abstract: This disclosure relates to a device in the form of a microfluidic chip. In particular, various features are incorporated into the microfluidic chip for aligning and orienting sperm in flow channels, as well as for separating selected subpopulations of sperm.Type: GrantFiled: March 14, 2013Date of Patent: August 6, 2019Assignee: Inguran, LLCInventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Erin Koksal, Kris Buchanan, Blair Morad
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Publication number: 20180243738Abstract: Systems and methods that enable the rapid identification of target molecules present in a sample at low concentrations is provided. The system includes a sample volume, and a detection structure that is connected to the sample volume by a conduit. The detection structure includes a microfluidic chip that defines a plurality of fluid channels. The walls of the fluid channels are formed from or covered with a metal oxide to which target molecules attach. After the sample volume has been passed through the detection structure, and in particular through the channels, visible microparticles are passed through the detection structure. The visible microparticles are configured to have an affinity for the target molecules. The microfluidic chip is then imaged to detect visible microparticles, and to thereby obtain information regarding the presence of the target molecules.Type: ApplicationFiled: February 26, 2018Publication date: August 30, 2018Inventors: John C. Gerdes, Kirsten L. Nelson, Kris Buchanan
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Patent number: 9927345Abstract: A nozzle assembly is disclosed. The nozzle assembly may include a nozzle outlet and enclose a nozzle cavity. A sample inlet formed in the nozzle housing may provide fluid communication to an injection tube mounted in an injection stem formed in the nozzle housing. One or more sheath inlet may provide fluid communication with the nozzle cavity and a downstream exit orifice.Type: GrantFiled: July 7, 2016Date of Patent: March 27, 2018Assignee: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 9757726Abstract: This disclosure relates to a system for sorting sperm cells in a microfluidic chip. In particular, various features are incorporated into the system for aligning and orienting sperm in flow channels, as well as, for determining sperm orientation and measuring relative DNA content for analysis and/or sorting.Type: GrantFiled: March 14, 2013Date of Patent: September 12, 2017Assignee: Inguran, LLCInventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Kris Buchanan, Blair Morad, Donald Francis Perrault, Jr., Erin Koksal
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Publication number: 20160320287Abstract: A nozzle assembly is disclosed. The nozzle assembly may include a nozzle outlet and enclose a nozzle cavity. A sample inlet formed in the nozzle housing may provide fluid communication to an injection tube mounted in an injection stem formed in the nozzle housing. One or more sheath inlet may provide fluid communication with the nozzle cavity and a downstream exit orifice.Type: ApplicationFiled: July 7, 2016Publication date: November 3, 2016Applicant: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 9404846Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: GrantFiled: March 14, 2013Date of Patent: August 2, 2016Assignee: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 9222872Abstract: A nozzle tip formed from a cylindrical body defining a longitudinal axis and a frustoconical body adjoining the cylindrical body on the longitudinal axis. The cylindrical body may be in fluid communication with the frustoconical body. The frustoconical body may end in a flat surface with a nozzle exit orifice which is transverse to the longitudinal axis. There may be a cutout at the edge of the frustoconical body and the flat surface. The flow cytometer system may also include a source of electromagnetic radiation for producing a beam incident upon the fluid stream and the particles and a detector for detecting light emitted or reflected from the particles within the fluid stream in response to the beam.Type: GrantFiled: September 19, 2013Date of Patent: December 29, 2015Assignee: Inguran, LLCInventors: Kris Buchanan, Kenneth Michael Evans
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Publication number: 20150219546Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: ApplicationFiled: March 4, 2013Publication date: August 6, 2015Applicant: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 9027850Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: GrantFiled: March 14, 2013Date of Patent: May 12, 2015Assignee: Inguran, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Publication number: 20140273192Abstract: This disclosure relates to a system for sorting sperm cells in a microfluidic chip. In particular, various features are incorporated into the system for aligning and orienting sperm in flow channels, as well as, for determining sperm orientation and measuring relative DNA content for analysis and/or sorting.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: INGURAN, LLCInventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Kris Buchanan, Blair Morad, Donald Francis Perrault, JR., Erin Koksal
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Publication number: 20140273179Abstract: This disclosure relates to a device in the form of a microfluidic chip. In particular, various features are incorporated into the microfluidic chip for aligning and orienting sperm in flow channels, as well as for separating selected subpopulations of sperm.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: INGURAN, LLCInventors: Johnathan Charles Sharpe, Nemanya Sedoglavich, Erin Koksal, Kris Buchanan, Blair Morad
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Publication number: 20140078502Abstract: A nozzle tip formed from a cylindrical body defining a longitudinal axis and a frustoconical body adjoining the cylindrical body on the longitudinal axis. The cylindrical body may be in fluid communication with the frustoconical body. The frustoconical body may end in a flat surface with a nozzle exit orifice which is transverse to the longitudinal axis. There may be a cutout at the edge of the frustoconical body and the flat surface. The flow cytometer system may also include a source of electromagnetic radiation for producing a beam incident upon the fluid stream and the particles and a detector for detecting light emitted or reflected from the particles within the fluid stream in response to the beam.Type: ApplicationFiled: September 19, 2013Publication date: March 20, 2014Applicant: Inguran, LLCInventors: Kris Buchanan, Kenneth Michael Evans
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Publication number: 20140076994Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: ApplicationFiled: March 14, 2013Publication date: March 20, 2014Applicant: INGURAN, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Publication number: 20140076986Abstract: A method of manufacturing a nozzle assembly may include the step of over molding a nozzle housing, or a portion of a nozzle housing, onto at least one nozzle component, such as an injection tube. Nozzle assemblies and flow cytometers incorporating nozzle assemblies may include any combination of straight smooth injection tubes, improved features for securing a nozzle assembly, improved features for debubbling a nozzle assembly, and aggressive orienting geometries. A method of sorting cells may include the step of magnetically coupling a nozzle assembly with a flow cytometer.Type: ApplicationFiled: March 14, 2013Publication date: March 20, 2014Applicant: INGURAN, LLCInventors: Kris Buchanan, Johnathan Charles Sharpe, Kenneth Michael Evans
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Patent number: 5517375Abstract: An assembly that couples a spindle shaft to the cover of a hard disk drive. The disk drive has a cover that is attached to a baseplate. Extending from the baseplate is a spindle shaft which supports a hub and the magnetic disk of the drive unit. The spindle shaft has a plurality of protrusions which are embedded into a metal shim. The metal shim is coupled to the cover by a sheet of elastomeric material. The metal shim and elastomeric sheet secure the end of the spindle shaft to the cover of the assembly.Type: GrantFiled: December 27, 1994Date of Patent: May 14, 1996Assignee: Maxtor CorporationInventors: F. Eugene Dion, Kris Buchanan