Patents by Inventor Kris Gevaert

Kris Gevaert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210079444
    Abstract: The present disclosure relates to the field of biochemistry, more particularly to detecting and measuring enzyme activity, even more particularly to detecting and measuring protease or nuclease activity. The means and methods disclosed in this application make use of Raman scattering, more particularly of surface enhanced Raman scattering (SERS). The disclosure discloses a carrier on which a monolayer of sequences containing a specific cleavage site is bound. The sequences comprise at least 2 Raman scatterers, one before and one behind the cleavage site, thereby providing an inherent control against ligand exchange.
    Type: Application
    Filed: June 27, 2018
    Publication date: March 18, 2021
    Inventors: Mohamed Lamkanfi, Kris Gevaert, Pieter Wuytens, Roel Baets
  • Publication number: 20060160131
    Abstract: The present invention relates to the field of drug development. More specifically the invention provides a method for the identification of drug targets. The method can also be used for analysis of proteomes. The method utilizes in essence a combination of two chromatographic separations of the same type, separated by a step in which the population of the drug-bound targets is altered specifically on the drug in such a way that the chromatographic behaviour of the altered drug-bound targets in the second chromatographic separation differs from the chromatographic behaviour of its unaltered version. The different chromatographic behaviour of the altered drug-bound targets is used for the isolation and subsequent identification of the targets.
    Type: Application
    Filed: September 11, 2003
    Publication date: July 20, 2006
    Inventors: Joel Vandekerckhove, Kris Gevaert
  • Publication number: 20050196823
    Abstract: Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alteration of one or more types of peptides. This alteration modifies the biophysical, chemical or any other biochemical property of the affected types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way that the altered peptides can be separated from the unaltered peptides.
    Type: Application
    Filed: September 28, 2004
    Publication date: September 8, 2005
    Inventors: Joel Vandekerckhove, Kris Gevaert
  • Patent number: 6908740
    Abstract: Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alteration of one or more types of peptides. This alteration modifies the biophysical, chemical or any other biochemical property of the affected types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way that the altered peptides can be separated from the unaltered peptides.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: June 21, 2005
    Inventors: Joel Vandekerckhove, Kris Gevaert
  • Publication number: 20040005633
    Abstract: Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alteration of one or more types of peptides. This alteration modifies the biophysical, chemical or any other biochemical property of the affected types of peptides (e.g., net electrical charge and/or hydrophobicity) in such way that the altered peptides can be separated from the unaltered peptides.
    Type: Application
    Filed: March 21, 2003
    Publication date: January 8, 2004
    Inventors: Joel Vandekerckhove, Kris Gevaert