Patents by Inventor Kris Lowe

Kris Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COLLAGEN 7 COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20260130965
    Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
    Type: Application
    Filed: August 25, 2025
    Publication date: May 14, 2026
    Inventors: Igor QUINONES-GARCIA, Lin GUEY, Kris LOWE, Vinh NGUYEN, Bing HE, Amey BANDEKAR, Sujit BASU
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20250121040
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: September 19, 2024
    Publication date: April 17, 2025
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • COMPOSITIONS AND METHODS FOR REDUCING OXIDATION OF IGF-1/IGFBP
    Publication number: 20250099541
    Abstract: The present invention provides, among other things, compositions and methods for reducing oxidation of a complex comprising insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), for treating diseases and complications of prematurity. In some embodiments, the methods comprise adding antioxidants. In some embodiments, the antioxidants are methionine or sodium thiosulfate. In some aspects, the compositions provided are stable, pure and potent compositions comprising IGF-1 and IGFBP-3. In some aspects, the formulation is lyophilized.
    Type: Application
    Filed: January 18, 2023
    Publication date: March 27, 2025
    Inventors: Nazila SALAMAT-MILLER, Kris LOWE, Michael HAHN, Katherine TAYLOR
  • Methods and compositions for CNS delivery of iduronate-2-sulfatase
    Patent number: 12121569
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: October 22, 2024
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • COLLAGEN 7 COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20230414698
    Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
    Type: Application
    Filed: February 15, 2023
    Publication date: December 28, 2023
    Inventors: Igor QUINONES-GARCIA, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20230026836
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: January 18, 2022
    Publication date: January 26, 2023
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • Methods and compositions for CNS delivery of iduronate-2-sulfatase
    Patent number: 11260112
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: March 1, 2022
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • COLLAGEN 7 COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20200316158
    Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
    Type: Application
    Filed: May 15, 2020
    Publication date: October 8, 2020
    Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
  • Collagen 7 compositions and methods of using the same
    Patent number: 10695395
    Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 30, 2020
    Assignee: PHOENIX TISSUE REPAIR, INC.
    Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20200046810
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: July 18, 2019
    Publication date: February 13, 2020
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • COLLAGEN 7 COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20190000912
    Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
    Type: Application
    Filed: December 21, 2016
    Publication date: January 3, 2019
    Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
  • STABILIZED COMPOSITIONS OF PROTEINS HAVING A FREE THIOL MOIETY
    Publication number: 20180104314
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Application
    Filed: May 26, 2017
    Publication date: April 19, 2018
    Applicant: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Gaozhong ZHU, Vinh NGUYEN, Kris LOWE, Zahra SHAHROKH
  • Stabilized compositions of proteins having a free thiol moiety
    Patent number: 9694057
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: July 4, 2017
    Assignee: SHIRE HUMA GENETIC THERAPIES, INC.
    Inventors: Gaozhong Zhu, Vinh Nguyen, Kris Lowe, Zahra Shahrokh
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20160158324
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: November 11, 2015
    Publication date: June 9, 2016
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Richard Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • Methods and compositions for CNS delivery of iduronate-2-sulfatase
    Patent number: 9220677
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 29, 2015
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Rick Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • STABILIZED COMPOSITIONS OF PROTEINS HAVING A FREE THIOL MOIETY
    Publication number: 20150283216
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Application
    Filed: June 18, 2015
    Publication date: October 8, 2015
    Applicant: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Gaozhong ZHU, Vinh NGUYEN, Kris LOWE, Zahra SHAHROKH
  • Stabilized compositions of proteins having a free thiol moiety
    Patent number: 9072785
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: July 7, 2015
    Assignee: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Gaozhong Zhu, Vinh Nguyen, Kris Lowe, Zahra Shahrokh
  • METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE
    Publication number: 20140271598
    Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
    Type: Application
    Filed: August 23, 2013
    Publication date: September 18, 2014
    Applicant: Shire Human Genetic Therapies, Inc.
    Inventors: Gaozhong Zhu, Kris Lowe, Zahra Shahrokh, James Christian, Rick Fahrner, Jing Pan, Teresa Leah Wright, Pericles Calias
  • STABILIZED COMPOSITIONS OF PROTEINS HAVING A FREE THIOL MOIETY
    Publication number: 20140219987
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 7, 2014
    Applicant: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Gaozhong Zhu, Vinh Nguyen, Kris Lowe, Zahra Shahrokh
  • Stabilized compositions of proteins having a free thiol moeity
    Patent number: 8673298
    Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: March 18, 2014
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Gaozhong Zhu, Vinh T. Nguyen, Kris Lowe, Zahra Shahrokh