Patents by Inventor Krisada Sakchaisri

Krisada Sakchaisri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tubulin polymerization inhibitor and method for synthesizing same
    Patent number: 9643959
    Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 9, 2017
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bo Yeon Kim, Thimmegowda N.R., Sun Ok Kim, Nak Kyun Soung, Krisada Sakchaisri, InJa Ryoo, Chan-Mi Park, Jong Seog Ahn, Jae-Hyuk Jang
  • Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-]furan-2-carbohydrazide derivatives as an active ingredient
    Patent number: 9433607
    Abstract: The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: September 6, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bo Yeon Kim, Krisada Sakchaisri, Sun Ok Kim, Ramegowda Thimmegowda Naraganahalli, Nak Kyun Soung, Jong Seog Ahn, Joonsung Hwang, In Ja Ryoo, Jae-Hyuk Jang
  • NOVEL TUBULIN POLYMERIZATION INHIBITOR AND METHOD FOR SYNTHESIZING SAME
    Publication number: 20160102078
    Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60%, or higher, leading to a very high yield, thereby providing an effective synthesis method.
    Type: Application
    Filed: April 22, 2014
    Publication date: April 14, 2016
    Inventors: Bo Yeon KIM, Thimmegowda N.R., Sun Ok KIM, Nak Kyun SOUNG, Krisada SAKCHAISRI, InJa RYOO, Chan-Mi PARK, Jong Seog AHN, Jae-Hyuk JANG
  • COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING N-METHYLENENAPHTHO[2,1-b]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AS AN ACTIVE INGREDIENT
    Publication number: 20150182502
    Abstract: The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
    Type: Application
    Filed: March 6, 2015
    Publication date: July 2, 2015
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bo Yeon Kim, Krisada Sakchaisri, Sun Ok Kim, Ramegowda Thimmegowda Naraganahalli, Nak Kyun Soung, Jong Seog Ahn, Joonsung Hwang, In Ja Ryoo, Jae-Hyuk Jang