Patents by Inventor Krisha Panchalingam

Krisha Panchalingam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for ex vivo propagation of adult hepatic stem cells
    Patent number: 7824912
    Abstract: The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. For example, the resulting cultured somatic liver stem cells can be used for a variety of applications including cell replacement therapies, gene therapies, drug discovery applications, and tissue engineering applications, such as the generation of artificial liver.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: November 2, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: James L. Sherley, Krisha Panchalingam
  • Methods for ex vivo propagation of adult hepatic stem cells
    Publication number: 20070020610
    Abstract: The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. For example, the resulting cultured somatic liver stem cells can be used for a variety of applications including cell replacement therapies, gene therapies, drug discovery applications, and tissue engineering applications, such as the generation of artificial liver.
    Type: Application
    Filed: June 21, 2006
    Publication date: January 25, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: James Sherley, Krisha Panchalingam