Patents by Inventor Krishan L. Kalra
Krishan L. Kalra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11506579Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.Type: GrantFiled: March 23, 2020Date of Patent: November 22, 2022Assignee: BioGenex Laboratories, Inc.Inventor: Krishan L. Kalra
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Publication number: 20200408652Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.Type: ApplicationFiled: March 23, 2020Publication date: December 31, 2020Applicant: BioGenex Laboratories, Inc.Inventor: Krishan L. Kalra
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Patent number: 10876937Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.Type: GrantFiled: October 3, 2014Date of Patent: December 29, 2020Assignee: BioGenex Laboratories, Inc.Inventor: Krishan L. Kalra
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Patent number: 10168257Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: GrantFiled: January 19, 2015Date of Patent: January 1, 2019Assignee: BioGenex Laboratories, Inc.Inventor: Krishan L. Kalra
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Patent number: 9551635Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: GrantFiled: August 17, 2009Date of Patent: January 24, 2017Assignee: Biogenex Laboratories Inc.Inventors: Krishan L. Kalra, Wallace Chang, Ravishankar Melkote
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Publication number: 20160299043Abstract: An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.Type: ApplicationFiled: October 3, 2014Publication date: October 13, 2016Inventor: Krishan L. Kalra
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Publication number: 20150260618Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: ApplicationFiled: January 19, 2015Publication date: September 17, 2015Inventor: Krishan L. Kalra
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Patent number: 8968675Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: GrantFiled: June 25, 2013Date of Patent: March 3, 2015Assignee: Biogenex Laboratories Inc.Inventor: Krishan L. Kalra
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Publication number: 20130338045Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: ApplicationFiled: June 25, 2013Publication date: December 19, 2013Applicant: Biogenex Laboratories Inc.Inventor: Krishan L. Kalra
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Publication number: 20100209298Abstract: In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.Type: ApplicationFiled: August 17, 2009Publication date: August 19, 2010Inventors: Krishan L. Kalra, Wallace Chang, Ravishankar Melkote, Shahzi Iqbal
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Patent number: 7472803Abstract: An automated dispensing assembly includes a base, and a shuttle mounted in the base and movable under automated control between a loading position and a dispensing position. The shuttle includes a cavity configured to carry an object, such as cover. The depth of the cavity in the shuttle is approximately the same (or less) as the thickness of one of the objects. A storage module is mounted proximate the shuttle. The storage module is configured to store a plurality of objects and includes an opening exposing the next object to be dispensed. The cavity is positioned adjacent the opening in the storage module in the loading position and an edge of the cavity separates the object to be dispensed from the other objects in the storage module as the shuttle moves to the dispensing position.Type: GrantFiled: February 25, 2005Date of Patent: January 6, 2009Assignee: BioGenex Laboratories, Inc.Inventors: Krishan L. Kalra, Thomas Maxwell, Qi Cao, Michael Huang, Shahin Iqbal
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Patent number: 7070951Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.Type: GrantFiled: August 29, 2003Date of Patent: July 4, 2006Assignee: BioGenex LaboratoriesInventors: Guangrong Zhang, Cheng-Zhi Yu, Sheng-Hui Su, Krishan L. Kalra, Ding Zhou
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Publication number: 20040219069Abstract: A device and methods for the automated histotechnological processing of a specimen are disclosed. The device comprises a microwave unit and a specimen positioning device which transports the specimen into a tank within the microwave unit where automated heating takes place. Preferably the microwave unit is controlled by a real-time microwave processor that permits control of the temperature within the microwave tank. Automated methods of dewaxing, antigen retrieval, nucleic acid retrieval, and hematoxylin and eosin staining which can be used in conjunction with the device are also provided. In one embodiment, a method is provided for simultaneous dewaxing and antigen retrieval; solutions useful for this method are also provided.Type: ApplicationFiled: January 22, 2004Publication date: November 4, 2004Inventors: Krishan L. Kalra, Jason Zhang, Mitchell Lok
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Publication number: 20040126399Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.Type: ApplicationFiled: August 29, 2003Publication date: July 1, 2004Inventors: Guangrong Zhang, Cheng-Zhi Yu, Sheng-Hui Su, Krishan L. Kalra, Ding Zhou
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Patent number: 6632598Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.Type: GrantFiled: March 11, 1994Date of Patent: October 14, 2003Assignee: BioGenex LaboratoriesInventors: Guangrong Zhang, Cheng-Zhi Yu, Sheng-Hui Su, Krishan L. Kalra, Ding Zhou
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Publication number: 20030175852Abstract: Methods and compositions for improving in situ hybridization analysis of aldehyde fixed tissue are described.Type: ApplicationFiled: March 17, 2003Publication date: September 18, 2003Inventors: Krishan L Kalra, Qian-Shu Wang, Jia Kuan Jin
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Publication number: 20030100043Abstract: A device and methods for the automated histotechnological processing of a specimen are disclosed. The device comprises a microwave unit and a specimen positioning device which transports the specimen into a tank within the microwave unit where automated heating takes place. Preferably the microwave unit is controlled by a real-time microwave processor that permits control of the temperature within the microwave tank. Automated methods of dewaxing, antigen retrieval, nucleic acid retrieval, and hematoxylin and eosin staining which can be used in conjunction with the device are also provided. In one embodiment, a method is provided for simultaneous dewaxing and antigen retrieval; solutions useful for this method are also provided.Type: ApplicationFiled: March 23, 2001Publication date: May 29, 2003Applicant: BioGenex Laboratories, Inc.Inventors: Krishan L. Kalra, Jason Zhang, Mitchell Lok
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Patent number: 6495106Abstract: Disclosed is an automated staining apparatus including an arm (30) moveable in three dimensions, and a hollow tip head (70) located on the arm including integral reagent tip head (40), wash tip (41) and blow tip (42) for selectively dispensing gas and liquid onto microscope slides. Also disclosed are various sub-components of the apparatus that are specifically adapted to the processing of specimens on slides.Type: GrantFiled: December 15, 2000Date of Patent: December 17, 2002Assignee: BioGenex LaboratoriesInventors: Krishan L. Kalra, Jason Z. Zhang, Zhi-Weng Chang, Jianghong Shui
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Patent number: 6451551Abstract: Releasing the embedding medium from an embedded histochemically reactive tissue specimen is provided by contacting the embedded tissue specimen with a releasing composition under conditions sufficient to release a sufficient portion of the embedding medium associated with the histochemically reactive tissue specimen to permit analysis without substantial adverse effect on the histochemical reactivity of the specimen.Type: GrantFiled: May 16, 2000Date of Patent: September 17, 2002Assignee: BioGenex LaboratoriesInventors: Guangrong Zhan, Krishan L. Kalra, Sheng-Hui Su, Taiying Chen
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Patent number: RE40835Abstract: A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the method comprising the steps of contacting the tissue with an aldehyde releasing reagent solution comprising a solvent and an aldehyde releasing reagent and removing aldehyde released by the aldehyde releasing reagent from contact with the tissue by reacting the aldehyde in a substantially irreversible manner to form a non-aldehyde derivative, and removing excess base from the tissue. A preferred solution for celloidin-embedded decalcified tissue comprises methanolic sodium hydroxide at about one-third saturation.Type: GrantFiled: August 12, 1993Date of Patent: July 7, 2009Assignee: BioGenx Laboratories, Inc.Inventors: Shan-Rong Shi, Atul K. Tandon, Krishan L. Kalra, Nagesh Malhotra, Sheng-Hui Su, Cheng-Zhi Yu