Abstract: An MRI scanner may include one or more gradient waveform generators, gradient amplifiers, gradient coils, an RF waveform generator, an RF amplifier, an RF coil, a superconducting magnet, an RF detector; a digitizer, and a computer system that controls the one or more gradient waveform generators and the RF waveform generator so as to generate a magnetization saturation preparation pulse sequence that includes a tip-down pulse that is insensitive to RF field inhomogeneity followed by a tip-back pulse that employs a conjugate symmetry constraint in its energy spectrum.