Patents by Inventor Krishna Jayaraman
Krishna Jayaraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11960435Abstract: A semiconductor package for skew matching in a die-to-die interface, including: a first die; a second die aligned with the first die such that each connection point of a first plurality of connection points of the first die is substantially equidistant to a corresponding connection point of a second plurality of connection points of the second die; and a plurality of connection paths of a substantially same length, wherein each connection path of the plurality of connection paths couples a respective connection point of the first plurality of connection points to the corresponding connection point of the second plurality of connection points.Type: GrantFiled: March 10, 2022Date of Patent: April 16, 2024Assignee: ADVANCED MICRO DEVICES, INC.Inventors: Pradeep Jayaraman, Dean Gonzales, Gerald R. Talbot, Ramon A. Mangaser, Michael J. Tresidder, Prasant Kumar Vallur, Srikanth Reddy Gruddanti, Krishna Reddy Mudimela Venkata, David H. McIntyre
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Publication number: 20210317528Abstract: Complex blood group typing can be performed at the DNA level, using for example, air-dried cheek swabs or finger prick blood in a microarray test that completely bypasses the need for DNA extraction prior to analysis of the blood group type.Type: ApplicationFiled: July 23, 2019Publication date: October 14, 2021Applicant: GENOMICS USA, INC.Inventors: FREDERICK H. EGGERS, GEORGINA LOPEZ PADILLA, PO LIN, KEVIN O'BRIEN, MICHAEL E. HOGAN, KRISHNA JAYARAMAN
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Patent number: 10888830Abstract: Provided herein are biomolecular hybridization devices comprising a substrate with a permanently and covalently attached surface of functional groups and an adsorbed monolayer of unmodified, single-stranded oligonucleotides all of which are 10 to about 24 bases in length as a saturated film of constrained oligonucleotides on the surface via direct non-covalent phosphate-surface adsorptive contact of substantially all phosphate groups of each oligonucleotide. The constrained oligonucleotides are effective to dissociably hybridize to a complementary single-stranded nucleic acid with asymmetric, non-helical base pairing and without oligonucleotide dissociation from the surface of the device. Also, provided are methods for hybridizing solution-state target nucleic acids to probe nucleic acids and for identifying a nucleotide sequence to which a nucleotide-binding protein binds using the biomolecular hybridization devices.Type: GrantFiled: March 20, 2018Date of Patent: January 12, 2021Assignees: Genomics USA, Inc., Baylor College of MedicineInventors: Michael E. Hogan, Joseph G. Utermohlen, Frederick H. Eggers, Krishna Jayaraman
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Publication number: 20140135231Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: ApplicationFiled: November 4, 2013Publication date: May 15, 2014Inventors: Michael E. Hogan, Krishna Jayaraman, Frederick H. Eggers, Rahul Mitra
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Patent number: 8575325Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: GrantFiled: May 21, 2012Date of Patent: November 5, 2013Assignee: Genomics USA, Inc.Inventors: Krishna Jayaraman, Rahul Mitra, Michael E Hogan, Frederick H Eggers
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Publication number: 20120302457Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: ApplicationFiled: May 21, 2012Publication date: November 29, 2012Applicant: GENOMICS USA, INC.Inventors: Krishna Jayaraman, Michael E. Hogan, Frederick H. Eggers, Rahul Mitra
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Patent number: 8183360Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: GrantFiled: February 18, 2010Date of Patent: May 22, 2012Assignee: Genomics USA, IncInventors: Rahul Mitra, Krishna Jayaraman, Frederick H. Eggers, Michäel E. Hogan
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Publication number: 20100279889Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: ApplicationFiled: February 18, 2010Publication date: November 4, 2010Inventors: Rahul Mitra, Krishna Jayaraman, Frederick H. Eggers, Michäel E. Hogan
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Patent number: 7667026Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: GrantFiled: February 27, 2007Date of Patent: February 23, 2010Assignee: Genomics USA, Inc.Inventors: Michael E. Hogan, Krishna Jayaraman, Rahul Mitra, Frederick H. Eggers
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Publication number: 20070298425Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.Type: ApplicationFiled: February 27, 2007Publication date: December 27, 2007Inventors: Michael Hogan, Krishna Jayaraman, Rahul Mitra, Frederick Eggers
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Patent number: 5614503Abstract: A nucleic acid transporter to deliver a nucleic acids into cells, comprising a cationic compound having a cationic head group for binding the nucleic acid and a lipid tail for association with the membrane. A cationic compound usually is a polyamine or a short basic peptide. The lipid tail is usually selected from the group consisting of plant steroid, animal steroid, isoprenoid compound, aliphatic lipid, pore forming protein, pore forming peptides and fusogenic peptides. The cationic head and the lipid tail are linked through a carbamate linkage. When polyamine is used, it is preferably either spermidine or spermine and the nucleic acid can be any of a variety, including triplex forming oligonucleotides, antisense oligonucleotide, aptamers, ribozymes, plasmids and DNA for gene therapy. Also described is a method for treating individuals using the transporter linked to a therapeutic nucleic acid.Type: GrantFiled: June 6, 1995Date of Patent: March 25, 1997Assignee: Aronex Pharmaceuticals, Inc.Inventors: Nilabh Chaudhary, Krishna Jayaraman, Veeraiah Bodepudi, Michael E. Hogan
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Patent number: 5132215Abstract: A method of synthesizing double-stranded DNA sequences is disclosed.Type: GrantFiled: September 15, 1988Date of Patent: July 21, 1992Assignee: Eastman Kodak CompanyInventors: Krishna Jayaraman, Brent A. Burdick, Fred T. Oakes