Patents by Inventor Krishna K. Murthi
Krishna K. Murthi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8518958Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.Type: GrantFiled: October 16, 2007Date of Patent: August 27, 2013Assignee: Forma Therapeutics, Inc.Inventors: Krishna K. Murthi, Rebecca Casaubon, Arthur F. Kluge, Chase C. Smith, Joachim Vogt
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Patent number: 8450348Abstract: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.Type: GrantFiled: February 21, 2007Date of Patent: May 28, 2013Assignee: Forma TM, LLCInventors: Krishna K. Murthi, Roland Köstler, Chase Smith, Tilman Brandstetter, Arthur F. Kluge
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Patent number: 8097619Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, untimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: GrantFiled: December 21, 2004Date of Patent: January 17, 2012Assignee: Agennix USA Inc.Inventors: Nicholas Bockovich, Arthur F. Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Patent number: 7893057Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: GrantFiled: June 18, 2009Date of Patent: February 22, 2011Assignee: Agennix USA Inc.Inventors: Nicholas Bockovich, Arthur Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Patent number: 7786112Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: GrantFiled: April 6, 2004Date of Patent: August 31, 2010Assignee: Agennix USA Inc.Inventors: Nicholas Bockovich, Arthur F. Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Publication number: 20100004207Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: ApplicationFiled: June 18, 2009Publication date: January 7, 2010Inventors: Nicholas Bockovich, Arthur Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Patent number: 7605175Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: GrantFiled: April 7, 2004Date of Patent: October 20, 2009Assignees: GPC Biotech AG, GPC Biotech, Inc.Inventors: Frank Becker, Nicholas Bockovich, Jon H. Come, Arthur F. Kluge, Krishna K. Murthi, Chris Oalmann, Siya Ram, Zhongguo Wang
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Publication number: 20090209530Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: ApplicationFiled: December 21, 2004Publication date: August 20, 2009Applicant: GPC Biotech, Inc.Inventors: Nicholas Bockovich, Arthur F. Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Publication number: 20080200523Abstract: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.Type: ApplicationFiled: February 21, 2007Publication date: August 21, 2008Inventors: Krishna K. Murthi, Roland Kostler, Chase Smith, Tilman Brandstetter, Arthur F. Kluge
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Publication number: 20080146555Abstract: The invention pertains to inhibitors of various kinases (e.g. S/T kinases, Tyr kinases, etc.), which inhibitors are previously known as cyclin dependent kinase inhibitors (CDKs). As described herein, the inhibitors of this invention are capable of inhibiting various wild-type and mutant form kinases, including drug resistant forms of mutant kinases. Thus the subject kinase inhibitors are useful in treating a wide range of diseases/conditions associated with abnormal functions/excessive activities of the target kinases, including mutant kinases. The invention further provides methods for treating cancers, tumors and patients which are resistant or refractory to other therapeutic agents. Pharmaceutical compositions and packaged pharmaceuticals with instructions of these inhibitors, and methods of using these inhibitors are also provided.Type: ApplicationFiled: June 17, 2005Publication date: June 19, 2008Applicant: GPC Biotech, IncInventors: Maureen G. Caligiuri, Nikolai A. Kley, Krishna K. Murthi
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Patent number: 7230101Abstract: The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target.Type: GrantFiled: August 28, 2003Date of Patent: June 12, 2007Assignee: GPC Biotech, Inc.Inventors: Krishna K. Murthi, Chase C. Smith
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Publication number: 20040266854Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: ApplicationFiled: April 7, 2004Publication date: December 30, 2004Applicants: GPC Biotech, Inc., GPC Biotech AGInventors: Frank Becker, Nicholas Bockovich, Jon H. Come, Arthur Kluge, Krishna K. Murthi, Chris Oalmann, Siya Ram, Zhongguo Wang
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Publication number: 20040266853Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: ApplicationFiled: April 6, 2004Publication date: December 30, 2004Applicant: GPC Biotech, Inc.Inventors: Nicholas Bockovich, Arthur Kluge, Chris Oalmann, Krishna K. Murthi, Siya Ram, Zhongguo Wang, Jianxing Huang
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Publication number: 20040235798Abstract: The present invention relates in part to compositions and methods for inhibiting prenyltransferases.Type: ApplicationFiled: May 7, 2004Publication date: November 25, 2004Inventors: Krishna K Murthi, Arthur Kluge
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Patent number: 6753329Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: GrantFiled: December 17, 2002Date of Patent: June 22, 2004Assignees: GPC Biotech Inc., GPC Biotech AGInventors: Nicholas Bockovich, Arthur Kluge, Chris Oalmann, Krishna K. Murthi, Frank Becker
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Publication number: 20030162797Abstract: The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.Type: ApplicationFiled: December 17, 2002Publication date: August 28, 2003Inventors: Nicholas Bockovich, Arthur Kluge, Siya Ram, Zhonghuo Wang, Chris Oalmann, Krishna K. Murthi
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Publication number: 20030050485Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.Type: ApplicationFiled: July 12, 2002Publication date: March 13, 2003Applicant: Florida State UniversityInventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase C. Smith, Feng Liang, Krishna K. Murthi
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Publication number: 20010053857Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.Type: ApplicationFiled: July 17, 2001Publication date: December 20, 2001Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase C. Smith, Feng Liang, Krishna K. Murthi
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Patent number: 5733920Abstract: The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These compounds can be used for inhibiting excessive or abnormal cell proliferation. Thus, the novel compounds are useful for treating a subject with a disorder associated with excessive cell proliferation, such as cancer.Type: GrantFiled: October 31, 1995Date of Patent: March 31, 1998Assignee: Mitotix, Inc.Inventors: Muzammil M. Mansuri, Krishna K. Murthi, Kollol Pal