Patents by Inventor Krishna Kodukula

Krishna Kodukula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prolyl Endopeptidase Probes
    Publication number: 20120065103
    Abstract: Prolyl endopeptidase (PE) activity in lung samples is detected by contacting the lung sample with a probe comprising a —P—X— (or —X—P—, —P—X—P—) PE recognition site, wherein P is a prolyl bioisostere, X is a residue that is not a prolyl bioisostere or is a prolyl bioisostere flanked on each side by a residue that is not a prolyl bioisostere, and “-” is an amide bond, under conditions wherein PE activity of the sample specifically hydrolyzes an amide bond of the recognition site to generate an optical signal; and (b) detecting the signal.
    Type: Application
    Filed: September 13, 2011
    Publication date: March 15, 2012
    Inventors: Amit K. Galande, Douglas Stuart Watson, Krishna Kodukula, Kalyani Jambunathan
  • Method for treating atherosclerosis employing an aP2 inhibitor and combination
    Publication number: 20090076033
    Abstract: A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatheroscletotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
    Type: Application
    Filed: April 15, 2008
    Publication date: March 19, 2009
    Inventors: Jeffrey A. Robl, Rex A. Parker, Scott A. Biller, Haris Jamil, Bruce L. Jacobson, Krishna Kodukula, Gokhan Hotamisligil
  • Method for treating diabetes employing an aP2 inhibitor and combination
    Patent number: 7390824
    Abstract: A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: June 24, 2008
    Assignees: Bristol-Myers Squibb Company, Pesident and Fellows of Harvard College
    Inventors: Jeffrey A. Robl, Rex A. Parker, Scott A. Biller, Haris Jamil, Bruce L. Jacobson, Krishna Kodukula
  • Method for treating atherosclerosis employing an aP2 inhibitor and combination
    Patent number: 7358254
    Abstract: A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: April 15, 2008
    Assignees: Bristol-Myers Squibb Company, President & Fellows of Harvard College
    Inventors: Jeffrey A. Robl, Rex A. Parker, Scott A. Biller, Haris Jamil, Bruce L. Jacobson, Krishna Kodukula, Gokhan Hotamisligil
  • Method for treating atherosclerosis employing an aP2 inhibitor and combination
    Publication number: 20040229807
    Abstract: A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
    Type: Application
    Filed: June 21, 2004
    Publication date: November 18, 2004
    Inventors: Jeffrey A. Robl, Rex A. Parker, Scott A. Biller, Haris Jamil, Bruce L. Jacobson, Krishna Kodukula
  • Method for treating atherosclerosis employing an aP2 inhibitor and combination
    Publication number: 20020035064
    Abstract: A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
    Type: Application
    Filed: July 13, 2001
    Publication date: March 21, 2002
    Inventors: Jeffrey A. Robl, Rex A. Parker, Scott A. Biller, Haris Jamil, Bruce L. Jacobson, Krishna Kodukula