Patents by Inventor KRISHNA KUMAR RAMACHANDRULA

KRISHNA KUMAR RAMACHANDRULA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of regorafenib and its crystalline forms
    Patent number: 9790185
    Abstract: The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I). The present invention further relates to a process for the purification of 4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I) to provide highly pure material. The present invention further relates to a process for the preparation stable crystalline material of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl pyridine-2-carboxamide or Regorafenib (I) useful in the preparation of pharmaceutical compositions for the treatment of cancer.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: October 17, 2017
    Assignee: SHILPA MEDICARE LIMITED
    Inventors: Sriram Rampalli, Lav Kumar Upalla, Krishna Kumar Ramachandrula, Prashant Purohit, Chaturvedi Akshay Kant
  • PROCESS FOR THE PREPARATION OF REGORAFENIB AND ITS CRYSTALLINE FORMS
    Publication number: 20170204062
    Abstract: The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I). The present invention further relates to a process for the purification of 4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I) to provide highly pure material. The present invention further relates to a process for the preparation stable crystalline material of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl pyridine-2-carboxamide or Regorafenib (I) useful in the preparation of pharmaceutical compositions for the treatment of cancer.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 20, 2017
    Applicant: SHILPA MEDICARE LIMITED
    Inventors: SRIRAM RAMPALLI, LAV KUMAR UPALLA, KRISHNA KUMAR RAMACHANDRULA, PRASHANT PUROHIT, CHATURVEDI AKSHAY KANT