Patents by Inventor Krishna M. Madduri

Krishna M. Madduri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytochrome P450 monooxgenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of candida tropicals and methods relating thereto
    Publication number: 20030049822
    Abstract: Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the &ohgr;-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of producing of cytochrome P450 and NADPH reductase enzymes are also provided which involve transforming a host cell with a gene encoding these enzymes and culturing the cells. Methods of increasing the production of a dicarboxylic acid and methods of increasing production of the aforementioned enzymes are also provided which involve increasing in the host cell the number of genes encoding these enzymes. A method for discriminating members of a gene family by quantifying the expression of genes is also provided.
    Type: Application
    Filed: May 3, 2002
    Publication date: March 13, 2003
    Inventors: C. Ron Wilson, David L. Craft, L. Dudley Eirich, Mark Eshoo, Krishna M. Madduri, Cathy A. Cornett, Alfred A. Brenner, Maria Tang, John C. Loper, Martin Gleeson
  • Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of candida tropicalis and methods relating thereto
    Publication number: 20030049821
    Abstract: Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the &ohgr;-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of producing of cytochrome P450 and NADPH reductase enzymes are also provided which involve transforming a host cell with a gene encoding these enzymes and culturing the cells. Methods of increasing the production of a dicarboxylic acid and methods of increasing production of the aforementioned enzymes are also provided which involve increasing in the host cell the number of genes encoding these enzymes. A method for discriminating members of a gene family by quantifying the expression of genes is also provided.
    Type: Application
    Filed: May 3, 2002
    Publication date: March 13, 2003
    Inventors: C. Ron Wilson, David L. Craft, L. Dudley Eirich, Mark Eshoo, Krishna M. Madduri, Cathy A. Cornett, Alfred A. Brenner, Maria Tang, John C. Loper, Martin Gleeson
  • Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto
    Patent number: 6503734
    Abstract: A novel gene has been isolated which encodes cytochrome b5 (CYTb5) protein of the &ohgr;-hydroxylase complex of C. tropicalis 20336. Vectors including this gene, and transformed host cells are provided. Methods of increasing the production of a CYTb5 protein are also provided which involve transforming a host cell with a gene encoding this protein and culturing the cells. Methods of increasing the production of a dicarboxylic acid are also provided which involve increasing in the host cell the number of genes encoding this protein.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: January 7, 2003
    Assignee: Cognis Corporation
    Inventors: David L. Craft, Krishna M. Madduri, John C. Loper
  • Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto
    Patent number: 6331420
    Abstract: Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the &ohgr;-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of producing of cytochrome P450 and NADPH reductase enzymes are also provided which involve transforming a host cell with a gene encoding these enzymes and culturing the cells. Methods of increasing the production of a dicarboxylic acid and methods of increasing production of the aforementioned enzymes are also provided which involve increasing in the host cell the number of genes encoding these enzymes. A method for discriminating members of a gene family by quantifying the expression of genes is also provided.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: December 18, 2001
    Inventors: C. Ron Wilson, David L. Craft, L. Dudley Eirich, Mark Eshoo, Krishna M. Madduri, Cathy A. Cornett, Alfred A. Brenner, Maria Tang, John C. Loper, Martin Gleeson
  • Process for preparing daunorubicin
    Patent number: 5563064
    Abstract: The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 and 4 and a nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: October 8, 1996
    Assignee: Farmitalia Carlo Erba S.R.L.
    Inventors: Charles R. Hutchinson, Krishna M. Madduri, Francesca Torti, Anna L. Colombo
  • Process for preparing daunorubicin
    Patent number: 5364781
    Abstract: The ability to convert carminomycin to daunorubicin can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 2, 3 & 4 and nucleotide sequence shown in FIG. 3 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for carminomycin 4-O-methyltransferase.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: November 15, 1994
    Assignee: Farmitalia Carlo ERBA S.r.l
    Inventors: Charles R. Hutchinson, Krishna M. Madduri, Francesca Torti, Anna L. Colombo