Abstract: Systems and methods are described for performing persistent inflight tracking of operations (Ops) within a cross-site storage solution. According to one embodiment, a method comprises maintaining state information regarding a data synchronous replication status for a first storage object of a primary storage cluster and a second storage object of a secondary storage cluster. The method includes performing persistent inflight tracking of I/O operations with a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster, establishing and comparing Op ranges for the first and second Op logs, and determining a relation between the Op range of the first Op log and the Op range of the second Op log to prevent divergence of Ops in the first and second Op logs and to support parallel split of the Ops.

Abstract: Techniques are provided for replay of metadata and data operations. During initial execution of operations, identifiers of objects modified by the execution of each operation are identified and stored in association with the operations. When the operations are to be replayed (e.g., executed again, such as part of a replication operation or as part of flushing content from a cache to persistent storage), the identifiers are evaluated to determine which operations are independent with respect to one another and which operations are dependent with respect to one another. In this way, independent operations are executed in parallel and dependent operations are executed serially with respect to the operations from the dependent operations depend.

Abstract: Techniques are provided for selectively allowing or blocking services from utilizing snapshots. A splitter intercepts and assigns timestamps to operations for execution upon files of a file system. If a snapshot is created while there are no pending operation, then the snapshot is tagged to indicate that the snapshot was created while there were no pending operations, and the snapshot is considered a tagged snapshot. Otherwise, the snapshot is not tagged, and is considered an untagged snapshot. Storage services (e.g., backup applications, lifecycle management applications, applications that consider timestamps of files, etc.) are allowed to utilize tagged snapshots and are blocked from utilizes untagged snapshots in order to maintain consistency.

Abstract: The present invention relates to a process for the preparation of Trametinib acetic acid solvate (Ia): The present invention also directed towards a pharmaceutical composition comprising Trametinib acetic acid solvate (Ia) and optionally one or more pharmaceutically acceptable excipients or carriers.

Abstract: It is provided a method, comprising monitoring if a discovery request is received by a network resource function, wherein the discovery request comprises at least one of a type identifier of a type of an application function and a range indication of a range of one or more subscription identifiers; identifying, if the discovery request is received, an identity of a network exposure function based on the at least one of the type identifier and the range indication, wherein a registration of the network exposure function at the network resource function comprises the at least one of the type identifier and the range indication; providing the identity of the network exposure function in response to the discovery request.

Abstract: Systems and methods for detecting one or more physical communication link breaks are disclosed. An indication of a failure of one or more network layer links may be received. A physical layer link associated with the one or more network layer links may be determined based on the indication of the failure, and based on data indicating one or more associations between network layer links and physical layer links. A score may be determined indicating a probability that the physical layer link comprises a failure associated with a break in a physical communication link of the physical layer link based on determining a total quantity of the network layer links associated with the physical layer link, and based on a quantity of one or more network layer links associated with the indication of the failure.

Abstract: Systems and methods are described for performing persistent inflight tracking of operations (Ops) within a cross-site storage solution. According to one embodiment, a method comprises maintaining state information regarding a data synchronous replication status for a first storage object of a primary storage cluster and a second storage object of a secondary storage cluster. The method includes performing persistent inflight tracking of I/O operations with a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster, establishing and comparing Op ranges for the first and second Op logs, and determining a relation between the Op range of the first Op log and the Op range of the second Op log to prevent divergence of Ops in the first and second Op logs and to support parallel split of the Ops.

Abstract: A method in a client backoff filter. The method includes receiving, from a server, a backoff data packet having backoff metadata. The method also includes saving the backoff metadata in a cache local to the client backoff filter. The method also includes receiving a subsequent request for service. The method also includes checking whether an attribute of the subsequent request for service matches the backoff metadata in the cache. The method also includes performing, responsive to checking, an action including at least one of the group including: blocking, responsive to the attribute matching the backoff metadata in the cache, transmission of the subsequent request for service to a server, and transmitting, responsive to the attribute failing to match the backoff metadata in the cache, the subsequent request for service to the server.

Abstract: The disclosure relates to a computer-implemented method for configuring at least one operation parameter in a network cell (140) served by a network node (110) of a communication network (100), the method comprising: (S210) obtaining at least one cell feature for each one of a plurality of network cells (140), the cell feature representing a cell state of respective network cell (140), (S220) clustering a number of network cells (140) into a number of cell clusters (160), wherein the clustering of network cells (140) is performed based on the obtained at least one cell feature of respective network cell (140), (S230) determining one network cell (140) of respective cell cluster (160) to be a representor cell (170), and for at least one cell cluster (160): (S240) determining at least one action (a) to be performed for configuring at least one operation parameter for a number of network cells (140) of respective cell cluster (160).

Abstract: The invention discloses vaccine for coronavirus and influenza virus and method for preparation thereof. More specifically, the invention discloses seasonal viral vaccine i. e. coronavirus and influenza virus vaccine for prophylaxis of novel coronavirus (SARS-CoV-2) infection (COVID-19) and Influenza virus in mammals and method for preparation of such vaccine. The invention discloses the stable combination vaccine compositions of killed-inactivated SARS-CoV-2, Influenza virus (A and B strains) as antigens. The present invention further discloses method of adaptation and growth seasonal influenza (A and B) strains in cell culture and methods of inactivation and purification of influenza virus bulk antigen. The present invention also discloses SARS-CoV-2 vaccine formulation with inactivated Influenza viruses and use of the same to elicit immune response against the SARS-CoV-2 and Influenza viruses in mammals and humans.

Abstract: A technique is directed to simulating a ransomware attack in a testing environment. The technique involves obtaining access to a testing environment in which to perform a simulated ransomware attack. The technique further involves, after obtaining access to the testing environment, loading prepared data into the testing environment. The technique further involves performing, as the simulated ransomware attack, a set of input/output (IO) operations based on a set of IO traces corresponding to an actual ransomware attack, the set of IO operations accessing the prepared data.

Abstract: The invention is directed to Muramyl Dipeptide (MDP) derivative compounds of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof: wherein, R can be a linear or branched alkyl, an aryl, a substituted aryl, or an alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are particularly useful as adjuvants in vaccines.

Abstract: The present invention discloses a system and method of generating robust immune response in mammals against SARS-CoV-2 antigen by administering two or more doses of same or different COVID-19 vaccines through same or different routes, wherein at least one vaccine is selected from a primary series of vaccines and at least one vaccine is selected from a secondary series of vaccines and wherein vaccines of primary and secondary series are administered through homologous or heterologous routes. The homologous route of administration comprises administering primary and secondary series of vaccines through same route. The heterologous route of administration comprises administering primary and secondary series vaccines through different routes. The system and method of the invention induces superior cross protection against SARS-CoV-2 variants including against Delta and Omicron variants.

Abstract: A method performed by a network node in a communication network for responding to a query of a first communication device to a second communication device related to a feature of a sense is provided. The method includes receiving a plurality of signatures generated from data including measurements of senses from at least one sensor. Each signature includes a plurality of features of the senses extracted from the measurements and mapped to each signature. The method further includes clustering a signature into a cluster having a classification. The method further includes searching a database that includes a mapping of features to defined labels of senses for the clusters to extract a response to the query. The method further includes signalling the response to the query of the first communication device.

Abstract: The present invention relates to pharmaceutical compositions comprising a Bruton tyrosine kinase (BTK) inhibitor. More particularly, the present invention relates to a composition comprising Acalabrutinib or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients and process for preparing such compositions.

Abstract: Methods and systems for unlocking an access point of a facility with a mobile device. Permissions and locations of access points of the facility that are accessible to a user of a particular mobile device may be downloaded and a location of the particular mobile device determined. The mobile device may identify one or more access points of the facility that are accessible by the user of the mobile device based on the location of the mobile device and the downloaded permissions and locations of the access points. The method may include displaying on the mobile device a notification of the access points that are identified by the mobile device, receiving a selection of one of the displayed access points from the user via a user interface of the mobile device, sending a command from the mobile device to unlock the selected access point, and unlocking the selected access point.

Abstract: A method in a client backoff filter. The method includes receiving, from a server, a backoff data packet having backoff metadata. The method also includes saving the backoff metadata in a cache local to the client backoff filter. The method also includes receiving a subsequent request for service. The method also includes checking whether an attribute of the subsequent request for service matches the backoff metadata in the cache. The method also includes performing, responsive to checking, an action including at least one of the group including: blocking, responsive to the attribute matching the backoff metadata in the cache, transmission of the subsequent request for service to a server, and transmitting, responsive to the attribute failing to match the backoff metadata in the cache, the subsequent request for service to the server.

Abstract: Multi-site distributed storage systems and computer-implemented methods are described for improving a resumption time of input/output (I/O) operations during a common snapshot process for storage objects. A computer-implemented method comprises performing a baseline transfer from at least one storage object of a first storage node to at least one replicated storage object of a second storage node, starting the common snapshot process including stop processing of I/O operations, performing a snapshot create operation on the primary storage site for the at least one storage object of the first storage node, resuming processing of I/O operations, and assigning a new universal unique identifier (UUID) to the at least one storage object of the second storage node after resuming processing of I/O operations with the new UUID to identify when file system contents are different than the baseline transfer.

Abstract: A data collection device and method for determining an alternative event condition is presented. The method includes receiving a first data communication including a first data value from a first sensor and determining a first event condition based on the first data value being beyond a predetermined threshold. The method further includes receiving additional data communications including additional data values from one or more second sensors, aggregating the first data value and the additional data values, and determining that the determination of the first event condition is incorrect based on the aggregated data values and a known relationship between the first sensor and the one or more second sensors. The method additionally includes determining a second event condition based on the first data value and the additional data values being beyond the predetermined threshold. An action may then be performed in response to the determination of the second event condition.

Abstract: The present invention generally relates to an improved process for the preparation of dapagliflozin of Formula I or its solvates or co-crystals thereof. Dapagliflozin is an inhibitor of sodium dependent glucose transporters and used for treating diabetes. The present invention also encompasses novel intermediates and their use in the preparation of dapagliflozin. An exemplary process according to the present is shown below, wherein X1, R1, R2, P1, P2, P3 and P4 are as described herein.