Abstract: The present disclosure provides amphiphilic peptide chaperones. Also provided are their incorporation into pharmaceutical compositions and methods of use for preventing or reducing a source of stress in cells and for the treatment of disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), cataract, age-related macular degeneration (AMD), glaucoma, and retinitis pigmentosa.

Abstract: The present disclosure provides amphiphilic peptide chaperones. Also provided are their incorporation into pharmaceutical compositions and methods of use for preventing or reducing a source of stress in cells and for the treatment of disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), cataract, age-related macular degeneration (AMD), glaucoma, and retinitis pigmentosa.

Abstract: A system for man-machine interaction for a vehicle is disclosed. The proposed system includes an interactive reflected display on a windscreen of the vehicle; an eye tracking module including an eye gaze tracker for tracking eye gaze direction of a user, and a training unit to train the tracking module using a neural network to predict a real-time set of coordinates for eye gaze direction of the user based on a created reference data set of coordinates of the display; a finger tracking module to detect presence of a finger of the user and track movement of the finger; a cursor module configured to, on the basis of a received input, move a cursor on the display to an area of interest on the display; and a wireless switch module operatively coupled to the display for selecting a target in the area of interest on the display.

Abstract: A system and method to store and retrieve energy includes a heat source or an energy consumer thermally connected to a fluid. The fluid is transported through a first well fluidically connected to a second well. A slot is sawed into a rock below the earth's surface and a cable and tubing connect the first well to the second well. The cable and the tubing are partially encapsulated by casing, wherein the cable stores heat. A plurality of materials is filled into the slot. A first hole is disposed beneath a first rig and surrounds the first well. A second hole is disposed beneath a second rig and surrounds the second well. The first hole and the second hole are configured to be vertical or slanted.

Abstract: The invention provides an sliding contact single vane rotary vacuum pump in which an oil supply passage is placed in the centre of the rotating vane through which a lubricating oil flows, which provides oil distribution in the pump chamber with enhanced suction pressure of 39%; and the torque exertion by 2.86-7.63%, this helps in reducing the torque of the pump during maximum vacuum condition and results in reduction of the power consumption of the vacuum pump which in-turn decreases the net load on the automotive engine, thus reduces the peak torque, the pump internal chamber pressure and also results better vacuum suction performance.

Abstract: This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

Abstract: This specification discloses a process to convert a converted lignin feedstream to an aromatic composition comprised of aromatic compounds. The process follows the steps of exposing the converted lignin feedstream to at least one catalyst in the presence of donated hydrogen atoms at an exposure temperature greater than 190° C. for a time of at least thirty minutes. The donated hydrogen atoms are donated from at least one hydrogen donating compound during exposure of the converted lignin feedstream to the at least one catalyst at the exposure temperature. The resulting products are comprised largely of aromatics.

Abstract: The present invention relates to a pharmaceutical composition comprising fingolimod and a weak acid cation exchange resin in the form of an ion-exchange complex and pharmaceutically acceptable 5 excipients.

Abstract: This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The continuous process further utilizes nanoparticles of a crystalline metal oxide. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

Abstract: The present invention relates to a pharmaceutical composition comprising fingolimod and a weak acid cation exchange resin in the form of an ion-exchange complex and pharmaceutically acceptable 5 excipients.

Abstract: The present invention relates to a pharmaceutical composition comprising fingolimod and a weak acid cation exchange resin in the form of an ion-exchange complex and pharmaceutically acceptable excipients.

Abstract: This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The continuous process further utilizes nanoparticles of a crystalline metal oxide. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

Abstract: This specification discloses a process to convert a converted lignin feedstream to an aromatic composition comprised of aromatic compounds. The process follows the steps of exposing the converted lignin feedstream to at least one catalyst in the presence of donated hydrogen atoms at an exposure temperature greater than 190° C. for a time of at least thirty minutes. The donated hydrogen atoms are donated from at least one hydrogen donating compound during exposure of the converted lignin feedstream to the at least one catalyst at the exposure temperature. The resulting products are comprised largely of aromatics.

Abstract: The present invention relates to a pharmaceutical composition comprising fingolimod and a weak acid cation exchange resin in the form of an ion-exchange complex and pharmaceutically acceptable excipients.