Patents by Inventor Krishnadatt Sharma

Krishnadatt Sharma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CRYSTALLINE FORM OF TICAGRELOR AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20150329546
    Abstract: The present invention refers to a new crystalline form of ticagrelor, a process for the preparation thereof, pharmaceutical compositions comprising said new crystalline form of ticagrelor, and the use of the new crystalline form of ticagrelor as medicament
    Type: Application
    Filed: November 29, 2012
    Publication date: November 19, 2015
    Inventors: Krishnadatt SHARMA, Nandkumar GAIKWAD, Nikhil TRIVEDI, Nitin Sharadchandra PRADHAN
  • Process for preparing quinoline-3-carboxamide derivatives
    Patent number: 9006443
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: April 14, 2015
    Assignee: Actavis Group PTC ehf
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Process for Preparing Quinoline-3-Carboxamide Derivatives
    Publication number: 20140005401
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 2, 2014
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Process for preparing quinoline-3-carboxamide derivatives
    Patent number: 8552194
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: October 8, 2013
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • HIGHLY PURE VARENICLINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF SUBSTANTIALLY FREE OF METHYLVARENICLINE IMPURITY
    Publication number: 20130101630
    Abstract: Provided herein is an impurity of varenicline, methylvarenicline, 6-methyl-5,8,14-triazatetracyclo[10.3.1.02,11,04,9]hexadeca-2(11),3,5,7,9-pentaene, and a process for the preparation and isolation thereof. Provided further herein is a highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity.
    Type: Application
    Filed: March 8, 2011
    Publication date: April 25, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Nitin Sharadchandra Pradhan, Arvapally Seshu Kumar, Nikhil Trivedi, Krishnadatt Sharma
  • Solid state forms of laquinimod and its sodium salt
    Patent number: 8354428
    Abstract: Provided herein is a novel crystalline form of laquinimod, process for the preparation, pharmaceutical compositions, and method of treating thereof. Provided also herein are novel amorphous and polymorphic forms of laquinimod sodium, process for the preparation, pharmaceutical compositions, and method of treating thereof.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 15, 2013
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Process for preparing varenicline, varenicline intermediates, pharmaceutically acceptable salts thereof
    Patent number: 8314235
    Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: November 20, 2012
    Assignee: Actavis Group PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan
  • AMORPHOUS VARENICLINE TARTRATE CO-PRECIPITATES
    Publication number: 20120093887
    Abstract: Disclosed herein is a stable amorphous coprecipitate comprising varenicline tartrate and a pharmaceutically acceptable excipient selected from the group consisting of maltodextrin, lactose monohydrate and 2-hydroxypropyl-?-cyclodextrin, method for the preparation, pharmaceutical compositions, and method of treating thereof. Advantageously, the amorphous coprecipitates of varenicline tartrate disclosed herein have improved physiochemical characteristics that assist in the effective bioavailability.
    Type: Application
    Filed: June 9, 2010
    Publication date: April 19, 2012
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Krishnadatt Sharma, Arvapally Seshu Kumar, Nitin Sharadchandra Pradhan
  • HIGHLY PURE LAQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120009226
    Abstract: Provided herein is an impurity of laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide (deschloro laquinimod impurity), and process for preparation and isolation thereof. Provided further herein is a highly pure laquinimod or a pharmaceutically acceptable salt thereof substantially free of deschloro laquinimod impurity, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure laquinimod or a pharmaceutically acceptable salt thereof substantially free of deschloro laquinimod impurity.
    Type: Application
    Filed: December 15, 2009
    Publication date: January 12, 2012
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Nitin Sharadchandra Pradhan
  • PROCESS FOR PREPARING VARENICLINE, VARENICLINE INTERMEDIATES, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20110224437
    Abstract: Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.02.7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.
    Type: Application
    Filed: August 31, 2009
    Publication date: September 15, 2011
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan
  • NOVEL SOLID STATE FORMS OF LAQUINIMOD AND ITS SODIUM SALT
    Publication number: 20110171270
    Abstract: Provided herein is a novel crystalline form of laquinimod, process for the preparation, pharmaceutical compositions, and method of treating thereof. Provided also herein are novel amorphous and polymorphic forms of laquinimod sodium, process for the preparation, pharmaceutical compositions, and method of treating thereof.
    Type: Application
    Filed: June 30, 2009
    Publication date: July 14, 2011
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Nitin Sharadchandra Pradhan, Jon Valgeirsson
  • Process for Preparing Quinoline-3-Carboxamide Derivatives
    Publication number: 20110105756
    Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: April 27, 2009
    Publication date: May 5, 2011
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Girish Dixit, Krishnadatt Sharma, Kundan Singh Shekhawat, Nitin Sharadchandra Pradhan, Jon Valgeirsson