Patents by Inventor Krishnakumar Sridharan
Krishnakumar Sridharan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932853Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.Type: GrantFiled: September 10, 2021Date of Patent: March 19, 2024Assignee: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh Desai, Krishnakumar Sridharan
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Patent number: 11859191Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpf1 and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: GrantFiled: August 3, 2022Date of Patent: January 2, 2024Assignee: Monsanto Technology LLCInventors: Stanislaw Flasinski, Elysia Krieger, Ervin Nagy, Krishnakumar Sridharan, Xudong Ye
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Publication number: 20230345947Abstract: Disclosed herein are compositions and methods of controlling pests that involves administering RNA interfering agents. Particularly exemplified is the control of Lepidopteran species such as diamondback moths and fall armyworms. Also disclosed is the use of double-stranded RNA molecules to target certain genes in Lepidopteran species.Type: ApplicationFiled: May 13, 2021Publication date: November 2, 2023Inventors: Kenneth E. NARVA, Krishnakumar SRIDHARAN, Upendra Kumar DEVISETTY, Thais BARROS RODRIGUES, Cris OPPERT, Suresh DESAI, Sambit Kumar MISHRA, Evelien VAN EKERT
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Publication number: 20230193302Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpfl and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: ApplicationFiled: August 3, 2022Publication date: June 22, 2023Applicant: Monsanto Technology LLCInventors: Stanislaw FLASINSKI, Elysia KRIEGER, Ervin NAGY, Krishnakumar SRIDHARAN, Xudong YE
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Publication number: 20230189818Abstract: Disclosed are agents, compositions and methods of treating or controlling Botrytis infection particularly in plants. Certain agents include polynucleotide molecules that induce RNAi when administered to B. cinerea fungal cells. In particular embodiments, compositions include a fungicidally effective amount of a polynucleotide comprising at least 18, 19, 20, 21, 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 575, or 600 contiguous nucleotides that are essentially complementary to or comprises at least about 85%, at least about 90%, at least about 95%, at least about 98%, about 100%, or 100% sequence identity with a segment of a DNA or target gene of B. cinerea, or an RNA transcribed from the DNA or target gene.Type: ApplicationFiled: July 26, 2022Publication date: June 22, 2023Inventors: Kestrel MCCORKLE, Christopher LAWRENCE, Krishnakumar SRIDHARAN, Upendra Kumar DEVISETTY, Sambit Kumar MISHRA, David CULLEY, Yufeng FANG
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Publication number: 20220290170Abstract: Disclosed herein are compositions and methods that involve recombinant polynucleotide molecules, such as single or double-stranded DNA or RNA molecules, also referred to “triggers”, that are useful for controlling or preventing E. necator infection, or recombinant DNA constructs for making such RNA molecules or for making transgenic grape plants resistant to E. necator infection. In some embodiments, polynucleotide triggers are provided as topically applied agents for controlling or preventing infection of a plant by E. necator. In some embodiments, grape plants with improved resistance to infection by E. necator, such as transgenic grape plants (including seeds or propagatable parts) expressing a polynucleotide trigger are provided. In some embodiments, grape plants (including seeds or propagatable parts) that have been topically treated with a composition comprising a polynucleotide trigger (e.g., grape plants that have been sprayed with a solution of dsRNA molecules) are provided.Type: ApplicationFiled: March 8, 2022Publication date: September 15, 2022Inventors: Adriana PURALEWSKI, Christopher LAWRENCE, Upendra Kumar DEVISETTY, Sambit Kumar MISHRA, Krishnakumar SRIDHARAN, Lance E. CADLE DAVIDSON, Ann N. UNDERHILL, Yufeng FANG, Wimalanathan KOKULAPALAN
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Patent number: 11414669Abstract: This disclosure is related to plant-optimized recombinant nucleic acids encoding Cpf1 and their use in planta. Also disclosed are compositions, expression cassettes, and plant cells comprising the recombinant nucleic acids as well as methods and kits for modifying a target sequence in a plant genome using the recombinant nucleic acids.Type: GrantFiled: September 6, 2019Date of Patent: August 16, 2022Assignee: MONSANTO TECHNOLOGY LLCInventors: Stanislaw Flasinski, Elysia Krieger, Ervin Nagy, Krishnakumar Sridharan, Xudong Ye
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Publication number: 20220235369Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention.Type: ApplicationFiled: January 13, 2022Publication date: July 28, 2022Inventors: David J. Bowen, Catherine A. Chay, Todd A. Ciche, Stanislaw Flainski, Arlene R. Howe, Krishnakumar Sridharan
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Patent number: 11225672Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention.Type: GrantFiled: October 21, 2019Date of Patent: January 18, 2022Assignee: Monsanto Technology LLCInventors: David J. Bowen, Catherine A. Chay, Todd A. Ciche, Stanislaw Flasinski, Arlene R. Howe, Krishnakumar Sridharan
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Publication number: 20220000123Abstract: Provided herein are methods for using RNAi molecules targeting an Inhibitor of Apoptosis (IAP) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting IAP, and compositions comprising RNAi molecules targeting IAP.Type: ApplicationFiled: September 26, 2019Publication date: January 6, 2022Applicant: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh D. Desai, Krishnakumar Sridharan
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Publication number: 20210403911Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.Type: ApplicationFiled: September 10, 2021Publication date: December 30, 2021Applicant: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh D. Desai, Krishnakumar Sridharan
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Publication number: 20210395738Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.Type: ApplicationFiled: November 8, 2019Publication date: December 23, 2021Applicant: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh D. Desai, Krishnakumar Sridharan
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Patent number: 11185079Abstract: Provided herein are methods for using RNAi molecules targeting an Inhibitor of Apoptosis (IAP) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting IAP, and compositions comprising RNAi molecules targeting IAP.Type: GrantFiled: September 26, 2019Date of Patent: November 30, 2021Assignee: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh D. Desai, Krishnakumar Sridharan
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Patent number: 11142768Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.Type: GrantFiled: November 8, 2019Date of Patent: October 12, 2021Assignee: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh Desai, Krishnakumar Sridharan
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Publication number: 20200149044Abstract: Provided herein are methods for using RNAi molecules targeting a proteasome beta 5 (PSMB5) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting PSMB5, and compositions comprising RNAi molecules targeting PSMB5.Type: ApplicationFiled: November 8, 2019Publication date: May 14, 2020Applicant: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh Desai, Krishnakumar Sridharan
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Publication number: 20200115721Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention.Type: ApplicationFiled: October 21, 2019Publication date: April 16, 2020Inventors: David J. Bowen, Catherine A. Chay, Todd A. Ciche, Stanislaw Flasinski, Arlene R. Howe, Krishnakumar Sridharan
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Publication number: 20200093138Abstract: Provided herein are methods for using RNAi molecules targeting an Inhibitor of Apoptosis (IAP) gene for controlling Coleopteran insects, methods for producing RNAi molecules targeting IAP, and compositions comprising RNAi molecules targeting IAP.Type: ApplicationFiled: September 26, 2019Publication date: March 26, 2020Applicant: GreenLight Biosciences, Inc.Inventors: Thais Barros Rodrigues, Suresh Desai, Krishnakumar Sridharan
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Patent number: 10465205Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention.Type: GrantFiled: April 3, 2018Date of Patent: November 5, 2019Assignee: Monsanto Technology LLCInventors: David J. Bowen, Catherine A. Chay, Todd A. Ciche, Stanislaw Flasinski, Arlene R. Howe, Krishnakumar Sridharan
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Publication number: 20180291395Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention.Type: ApplicationFiled: April 3, 2018Publication date: October 11, 2018Inventors: David J. Bowen, Catherine A. Chay, Todd A. Ciche, Stanislaw Flasinski, Arlene R. Howe, Krishnakumar Sridharan