Patents by Inventor Krishnakumar SUBBIAH

Krishnakumar SUBBIAH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210214702
    Abstract: The present invention pertains to an economic packed-bed perfusion system for the production of pharmaceutical grade of recombinant TNK-tPA. The present invention involves a cell culture process utilizing CHO cells more specifically in a micro/macro carriers based packed-bed perfusion system. The process of the present invention results in optimum cell growth and maintenance, and minimal build-up of toxic by-products such as lactate and ammonia. The system of the present invention discloses optimized process parameters to enable a resultant TNK-tPA with high yield and pharmaceutical grade purity. The process of the present invention is industrially applicable and possesses economy of scale.
    Type: Application
    Filed: May 21, 2019
    Publication date: July 15, 2021
    Applicant: GENNOVA BIOPHARMACEUTICALS LIMITED
    Inventors: Kameleshwar Prasad SINGH, Krishnakumar SUBBIAH, Sanjay SINGH, Santosh DESHPANDE