Patents by Inventor Krishnan K. Palaniappan

Krishnan K. Palaniappan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isotopic recoding for targeted tandem mass spectrometry
    Patent number: 9410966
    Abstract: Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of N-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled N-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry. A predetermined isotopic pattern in the mass spectrum is identified and amino acid sequences of the peptides containing the predetermined isotopic pattern are determined. Systems for identifying a predetermined isotopic pattern in mass spectra and determining amino acid sequences of peptides containing the predetermined isotopic pattern are also described.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: August 9, 2016
    Assignee: The Regents of the University of California
    Inventors: Carolyn R. Bertozzi, Brian P. Smart, Austin A. Pitcher, Krishnan K. Palaniappan, Mark A. Breidenbach
  • ISOTOPIC RECODING FOR TARGETED TANDEM MASS SPECTROMETRY
    Publication number: 20140199716
    Abstract: Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of N-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled N-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry. A predetermined isotopic pattern in the mass spectrum is identified and amino acid sequences of the peptides containing the predetermined isotopic pattern are determined. Systems for identifying a predetermined isotopic pattern in mass spectra and determining amino acid sequences of peptides containing the predetermined isotopic pattern are also described.
    Type: Application
    Filed: January 15, 2014
    Publication date: July 17, 2014
    Applicant: The Regents of the University of California
    Inventors: Carolyn R. Bertozzi, Brian P. Smart, Austin A. Pitcher, Krishnan K. Palaniappan, Mark A. Breidenbach