Abstract: The present innovation relates to the field of biomaterials, drug delivery systems, load-bearing materials for bone regeneration and dental restauration. The method for fabrication of amorphous calcium phosphate ceramic-based drug delivery system is proposed. According to the method, mixture of amorphous calcium phosphate and at least one drug is sintered at pressure that exceeds 500 MPa, preferably in the range of 600 to 1500 MPa, at temperature from 15 to 35° C. The selected pressure range allows to obtain on amorphous calcium phosphate ceramic-based long-term drug delivery system with excellent mechanical properties.