Patents by Inventor Kristen Billiar
Kristen Billiar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10624622Abstract: A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision for affording access to deeper structures for inserting osteosynthesis hardware in the surgical treatment of a distal radius fracture or other surgical procedure. The prongs extend from retractors that traverse the locking track for opposed linear movement while recessed in a surgical working region accessible through an incision. The prongs terminate in curvatures defining a void that gather and engage the elongated anatomical structures on top of the skeletal members receiving the plate. The prongs draw back the tendons, blood vessels and nerve structures to allow unimpeded surgical access for manipulating and attaching skeletal and soft tissue members and/or appliances.Type: GrantFiled: April 19, 2017Date of Patent: April 21, 2020Assignees: Worcester Polytechnic Institute, University of MassachusettsInventors: Jacquelyne DiTroia, Caroline Mazzola, Andres Monterroso, Patricia Swierk, Arriyan Samandar Dowlatshahi, Kristen Billiar, Raymond M. Dunn
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Publication number: 20170296159Abstract: A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision for affording access to deeper structures for inserting osteosynthesis hardware in the surgical treatment of a distal radius fracture or other surgical procedure. The prongs extend from retractors that traverse the locking track for opposed linear movement while recessed in a surgical working region accessible through an incision. The prongs terminate in curvatures defining a void that gather and engage the elongated anatomical structures on top of the skeletal members receiving the plate. The prongs draw back the tendons, blood vessels and nerve structures to allow unimpeded surgical access for manipulating and attaching skeletal and soft tissue members and/or appliances.Type: ApplicationFiled: April 19, 2017Publication date: October 19, 2017Inventors: Jacquelyne DiTroia, Caroline Mazzola, Andres Monterroso, Patricia Swierk, Kristen Billiar, Arriyan Samandar Dowlatshahi, Raymond M. Dunn
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Patent number: 9662415Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.Type: GrantFiled: July 9, 2015Date of Patent: May 30, 2017Assignee: WORCESTER POLYTECHNIC INSTITUTEInventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
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Patent number: 9566098Abstract: An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.Type: GrantFiled: April 19, 2012Date of Patent: February 14, 2017Assignees: University of Massachusetts, Worcester Polytechnic InstituteInventors: Raymond Dunn, Kristen Billiar, Janice Lalikos, Alexander Christakis, John Dieselman
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Publication number: 20160095954Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.Type: ApplicationFiled: July 9, 2015Publication date: April 7, 2016Inventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
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Publication number: 20150025009Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.Type: ApplicationFiled: July 29, 2014Publication date: January 22, 2015Inventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
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Patent number: 8865869Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.Type: GrantFiled: March 15, 2007Date of Patent: October 21, 2014Assignee: Worcester Polytechnic InstituteInventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
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Patent number: 8690927Abstract: An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The locking mechanism can include a second screw to actuate and expansion portion of screw inserted into the bone. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.Type: GrantFiled: March 24, 2011Date of Patent: April 8, 2014Assignee: University of MassachusettsInventors: Raymond Dunn, Kristen Billiar, Janice Lalikos, Alexander Christakis, John Dieselman
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Publication number: 20120323283Abstract: An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.Type: ApplicationFiled: April 19, 2012Publication date: December 20, 2012Inventors: Raymond Dunn, Janice Lalikos, Kristen Billiar, Alexander Christakis, John Dieselman
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Publication number: 20120253407Abstract: An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The locking mechanism can include a second screw to actuate and expansion portion of screw inserted into the bone. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.Type: ApplicationFiled: March 24, 2011Publication date: October 4, 2012Inventors: Raymond Dunn, Kristen Billiar, Janice Lalikos, Alexander Christakis, John Dieselman
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Publication number: 20110034388Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.Type: ApplicationFiled: March 15, 2007Publication date: February 10, 2011Inventors: Kevin G. Cornwell, George D. Pins, Kristen Billiar
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Publication number: 20070003633Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: ApplicationFiled: April 14, 2005Publication date: January 4, 2007Inventors: Ginger Abraham, Maury Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller
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Publication number: 20060030791Abstract: The preferred embodiments of the present invention are directed at a device that provides a reliable, accurate and quantifiable measure of a patient's edema. The device improves on the current method of digital manipulation by evaluating the pitting phenomena in a user-independent manner. The output of the device allows a physician to categorize edema into at least ten different levels of severity. The systems of the present invention provides the ability to distinguish between tissues of varying viscosity.Type: ApplicationFiled: April 15, 2005Publication date: February 9, 2006Inventors: Kristen Billiar, Raymond Dunn
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Patent number: 6978815Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: GrantFiled: December 19, 2002Date of Patent: December 27, 2005Assignee: Organogenesis Inc.Inventors: Maury D. Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller
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Publication number: 20030234469Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: ApplicationFiled: December 19, 2002Publication date: December 25, 2003Applicant: Organogenesis, Inc.Inventors: Maury D. Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller