Patents by Inventor Kristen Kahle

Kristen Kahle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies against chikungunya virus and uses thereof
    Patent number: 9902765
    Abstract: Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 27, 2018
    Assignees: INTEGRAL MOLECULAR, INC., BLOOD SYSTEMS RESEARCH INSTITUTE
    Inventors: Benjamin Doranz, Kimberly-Anne Mattia, Kristen Kahle, Graham Simmons, Rachel Hua-Ning Fong, Soma Banik Banerjee
  • ANTIBODIES AGAINST CHIKUNGUNYA VIRUS AND USES THEREOF
    Publication number: 20160145323
    Abstract: Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
    Type: Application
    Filed: July 21, 2014
    Publication date: May 26, 2016
    Inventors: Benjamin DORANZ, Kimberly-Anne MATTIA, Kristen KAHLE, Graham SIMMONS
  • TIGHTER-BINDING C-PEPTIDE INHIBITORS OF HIV-1 ENTRY
    Publication number: 20100029568
    Abstract: The invention provides compositions and methods for the treatment of HIV infection, inhibition against drug-resistant strains of HIV-1 and methods of enhancing the anti-HIV potency of peptide inhibitors against drug-resistant strains of HIV-1. In particular, oligomeric C-peptide inhibitors for inhibiting HIV entry into host cells are disclosed.
    Type: Application
    Filed: March 12, 2008
    Publication date: February 4, 2010
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Kristen Kahle, Suparna Paul, H. Kirby Steger, Michael J. Root