Patents by Inventor Kristen Mae Hege

Kristen Mae Hege has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating cancer using TOR kinase inhibitor combination therapy
    Patent number: 9358232
    Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide to a patient having a cancer.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: June 7, 2016
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Kristen Mae Hege, Rajesh Chopra
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20160008356
    Abstract: Provided herein are methods for treating or preventing a neuroendocrine tumor of non-gut origin in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a neuroendocrine tumor of non-gut origin.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 14, 2016
    Inventor: Kristen Mae HEGE
  • TREATMENT OF CANCER CHARACTERIZED BY GENE MUTATIONS
    Publication number: 20150099754
    Abstract: Provided herein are methods for treating and/or preventing a cancer in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer characterized by particular gene mutation(s) or variant(s) relative to the genes of a biological wild-type sample.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Shuichan Xu, Kristen Mae Hege, Xiaoling Wu, Zhihong Yang, Konstantinos Mavrommatis, Ellen Filvaroff
  • METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY
    Publication number: 20140314752
    Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of an IMiD® immunomodulatory drug to a patient having a cancer.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC
    Inventors: ANTONIA LOPEZ-GIRONA, KRISTEN MAE HEGE, RAJESH CHOPRA
  • METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY
    Publication number: 20140314751
    Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide to a patient having a cancer.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: KRISTEN MAE HEGE, RAJESH CHOPRA
  • TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES
    Publication number: 20140314674
    Abstract: Provided herein are methods for treating or preventing glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound to a patient having glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression and/or promoter methylation status.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC
    Inventors: HEATHER RAYMON, KRISTEN MAE HEGE
  • TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES
    Publication number: 20140315907
    Abstract: Provided herein are methods for treating or preventing chronic lymphocytic leukemia, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound to a patient having chronic lymphocytic leukemia.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC
    Inventors: HEATHER RAYMON, SHUICHAN XU, ANTONIA LOPEZ-GIRONA, TOSHIYA TSUJI, KRISTEN MAE HEGE
  • METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY
    Publication number: 20140314753
    Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of a 5-Substituted Quinazolinone Compound to a patient having a cancer.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC.
    Inventors: KRISTEN MAE HEGE, RAJESH CHOPRA
  • METHODS FOR TREATING CANCER USING DIHYDROPYRAZINO-PYRAZINE COMPOUND COMBINATION THERAPY
    Publication number: 20140315900
    Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound and an effective amount of an androgen receptor antagonist to a patient having a cancer.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC
    Inventors: HEATHER RAYMON, TOSHIYA TSUJI, RAMA K. NARLA, KRISTEN MAE HEGE
  • TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES
    Publication number: 20140314673
    Abstract: Provided herein are methods for treating or preventing head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression, comprising administering an effective amount of a dihydropyrazino-pyrazine to a patient having head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Signal Pharmaceuticals, LLC
    Inventors: HEATHER RAYMON, SHUICHAN XU, TOSHIYA TSUJI, KRISTEN MAE HEGE
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20140113904
    Abstract: Provided herein are methods for treating or preventing prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having prostate cancer.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 24, 2014
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: Deborah Mortensen, Heather Raymon, Rama K. Narla, Kristen Mae Hege, Kimberly Elizabeth Fultz, Toshiya Tsuji
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20130245027
    Abstract: Provided herein are methods for treating or preventing triple negative breast cancer or hormone receptor positive breast cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having triple negative breast cancer or hormone receptor positive breast cancer.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: Shuichan Xu, Kristen Mae Hege, Heather Raymon, Rama K. Narla
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20130245029
    Abstract: Provided herein are methods for treating or preventing ETS overexpressing Ewings sarcoma, comprising administering an effective amount of a TOR kinase inhibitor to a patient having ETS overexpressing Ewings sarcoma.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: Shuichan Xu, Kristen Mae Hege
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20130245028
    Abstract: Provided herein are methods for treating or preventing ETS overexpressing castration-resistant prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having ETS overexpressing castration-resistant prostate cancer.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: Shuichan Xu, Kristen Mae Hege, Heather Raymon, Toshiya Tsuji, Lisa Sapinoso
  • TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
    Publication number: 20130245026
    Abstract: Provided herein are methods for treating or preventing head and neck squamous cell carcinoma, comprising administering an effective amount of a TOR kinase inhibitor to a patient having head and neck squamous cell carcinoma.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: SIGNAL PHARMACEUTICALS, LLC
    Inventors: Shuichan Xu, Kristen Mae Hege, Heather Raymon, Lilly Loraine Wong