Abstract: The disclosure provides, in various embodiments, polypeptides (e.g., antibodies and antigen binding fragments thereof) that specifically bind to a thymic stromal lymphopoietin (TSLP) (e.g., a full-length human TSLP). The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, and methods for treating a TSLP-associated disease or condition.

Abstract: The invention provides, inter alia, synthetic parathyroid hormones (sPTHs) that can modulate the activity of parathyroid hormone receptor, such as parathyroid hormone receptor 1 (PTHR1). The invention also provides methods of modulating PTHR activity using these sPTHs, e.g., in a cell, such as a cell in an organism.