Patents by Inventor Kristen Picha

Kristen Picha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition comprising a human GLP-1 mimetibody
    Patent number: 8071103
    Abstract: The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: December 6, 2011
    Assignee: Centocor, Inc.
    Inventors: Karyn T. O'Neil, Kristen Picha
  • sRAGE mimetibody, compositions, methods and uses
    Patent number: 8043616
    Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: October 25, 2011
    Assignee: Centocor, Inc.
    Inventors: Glenn Mark Anderson, Robert Jordan, Kristen Picha
  • Anti-GLP-1R Antibodies and Their Uses
    Publication number: 20110098443
    Abstract: The present invention relates to antibodies reactive with GLP-1R, and methods of making and using them.
    Type: Application
    Filed: October 27, 2010
    Publication date: April 28, 2011
    Inventors: Karyn O'Neil, Kristen Picha
  • RESISTIN ANTAGONISTS AND THEIR USE
    Publication number: 20110071277
    Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
    Type: Application
    Filed: March 12, 2010
    Publication date: March 24, 2011
    Inventors: Simon Blake, Jill Carton, Jennifer Henrica Lee, Keying Ma, Paul Marsters, Kristen Picha, Xiao-Yu R. Song, Francis Farrell, Lynne Murray, Alexey Teplyakov, Tatiana Ort
  • Method for treating insulin sensitivity by long-acting GLP-1 receptor mimetibody agonists
    Patent number: 7833531
    Abstract: The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: November 16, 2010
    Assignee: Centocor, Inc.
    Inventors: Karyn T. O'Neil, Kristen Picha, Vedrana Stojanovic-Susulic
  • GLP-2 mimetibodies, polypeptides, compositions, methods and uses
    Patent number: 7812121
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: October 12, 2010
    Inventors: Audrey E. Baker, Beverly A. Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey M. Palmer, Kristen Picha, Sarah Sague
  • HUMAN EPO RECEPTOR AGONISTS, COMPOSITIONS, METHODS AND USES FOR PREVENTING OR TREATING GLUCOSE INTOLERANCE RELATED CONDITIONS
    Publication number: 20100183592
    Abstract: The present invention relates to at least one human EPO receptor agonist methods for preventing or treating glucose intolerance and/or renal disease associated anemia, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: September 28, 2007
    Publication date: July 22, 2010
    Inventors: Ian E. James, Kristen Picha
  • HUMAN EPO MIMETIC HINGE CORE MIMETIBODIES, COMPOSITIONS, METHODS AND USES FOR PREVENTING OR TREATING GLUCOSE INTOLERANCE RELATED CONDITIONS ON RENAL DISEASE ASSOCIATED ANEMIA
    Publication number: 20100034819
    Abstract: The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, and methods of making and using thereof, for preventing or treating glucose intolerance and/or renal disease associated anemia, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: March 30, 2007
    Publication date: February 11, 2010
    Applicant: CENTOCOR INC.
    Inventors: Ian E. James, Kristen Picha
  • HUMAN GLP-1 MIMETIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20090325873
    Abstract: The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: July 18, 2007
    Publication date: December 31, 2009
    Applicant: CENTOCOR, INC.
    Inventors: Karyn T. O'Neil, Kristen Picha
  • RESISTIN ANTAGONISTS AND THEIR USE
    Publication number: 20090162375
    Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
    Type: Application
    Filed: October 25, 2007
    Publication date: June 25, 2009
    Inventors: Simon Blake, Jill Carton, Jennifer Henrica Lee, Keying Ma, Paul Marsters, Kristen Picha, Xiao-Yu R. Song, Francis Farrell, Lynne Murray, Alexey Teplyakov, Tatiana Ort
  • GLP-2 Mimetibodies, Polypeptides, Compositions, Methods and Uses
    Publication number: 20090117104
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 7, 2009
    Inventors: Audrey E. Baker, Beverly A. Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey M. Palmer, Kristen Picha, Sarah Sague
  • USE OF LONG-ACTING GLP-1 RECEPTOR AGONISTS TO IMPROVE INSULIN SENSITIVITY AND LIPID PROFILES
    Publication number: 20090098108
    Abstract: The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the use of long acting GLP-1 receptor agonists to improve insulin sensitivity or lipid profiles in obesity and related therapeutic and/or diagnostic compositions, methods and devices.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 16, 2009
    Inventors: Karyn T. O'Neil, Kristen Picha, Vedrana Stojanovic-Susulic
  • sRAGE Mimetibody, Compositions, Methods and Uses
    Publication number: 20090098122
    Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.
    Type: Application
    Filed: July 17, 2008
    Publication date: April 16, 2009
    Inventors: Glenn Mark Anderson, Robert Jordan, Kristen Picha
  • HUMAN GLP-1 MIMETIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20080044411
    Abstract: The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Karyn O'NEIL, Kristen Picha
  • GLP-2 Mimetibodies, Polypeptides, Compositions, Methods and Uses
    Publication number: 20070212355
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 13, 2007
    Inventors: Audrey Baker, Beverly Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey Palmer, Kristen Picha, Sarah Sague
  • Human GLP-1 mimetibodies, compositions, methods and uses
    Publication number: 20070135338
    Abstract: The present invention relates to at least one novel human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: March 28, 2005
    Publication date: June 14, 2007
    Inventors: Karyn O'Neil, Kristen Picha
  • GLP-1 agonists, compositions, methods and uses
    Publication number: 20070128193
    Abstract: The present invention relates to at least one novel human GLP-1 mimetibody or agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or agonist, or specified portion or variant, GLP-1 mimetibody or agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including diabetes related therapeutic and/or diagnositic compositions, methods and devices.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 7, 2007
    Inventors: Karyn O'Neil, Kristen Picha, John O'Neil, Gang Xu, Michael Lark
  • Toll like receptor 3 antagonists, methods and uses
    Publication number: 20060115475
    Abstract: Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 1, 2006
    Inventors: Jill Carton, Shizhong Chen, Mark Cunningham, Anuk Das, Karen Duffy, Jill Giles-Komar, Theresa Goletz, David Knight, Roberta Lamb, Mouhamadou Mbow, Kristen Picha, Gopalan Raghunathan, Lani San Mateo, Robert Sarisky, Vedrana Stojanovic-Susulic, Nicole Stowell, Raymond Sweet, Shanrong Zhao
  • sRAGE mimetibody, compositions, methods and uses
    Publication number: 20060084145
    Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.
    Type: Application
    Filed: September 27, 2005
    Publication date: April 20, 2006
    Inventors: Glenn Anderson, Robert Jordan, Kristen Picha