Abstract: Arranging computational sub-tasks in a hybrid-computing environment is provided. The method comprises receiving input of a number of nodes, wherein each node represents a computational sub-task, and wherein the nodes are grouped into different sets according to differing computing resources used by the nodes. A computational objective is also received as well as initial data inputs and desired final outputs. A directed graph network is generated comprising the nodes and directed edges connecting the nodes. An optimization problem is then solved to determine a best path through the directed graph network for deriving the desired final outputs from the initial data inputs according to the computational objective. The best path comprises a subset of nodes and directed edges within the directed graph network. The best path to achieve the computational objective and estimated computational resources required for the best path are output to a user.

Abstract: A method of minimizing a cost function of a quantum computation is provided. The method comprises receiving input of an initial state of a quantum problem instance comprising a Hamiltonian with an associated cost function. The Hamiltonian is converted into a number of Pauli strings, which are used to form an operator pool. The Pauli strings in the operator pool are ranked according to how much they lower a value of the cost function with respect to the initial state. Pauli strings are iteratively added from the operator pool to a parameterized quantum circuit, in a manner to minimize circuit depth, until a variational quantum eigensolver (VQE) algorithm converges to an approximate ground state wave function generated by the parameterized quantum circuit.

Abstract: A new and distinct variety of rose plant, referred to by its cultivar name, ‘MEIJOVAUX’, is disclosed. The new variety forms attractive, semi-double creamy pink with a creamy yellow center colored flowers. Attractive rather dense with a semi-glossy aspect foliage is formed, which contrasts beautifully with the blossoms. A ground cover growth habit is displayed. The new variety is well suited for providing attractive ornamentation in the landscape.

Abstract: In one aspect, an apparatus includes a chamber configured to control one or more of humidity, pressure, or temperature and a jaw configured to flex a material system. The chamber includes an enclosure disposed within the chamber, the enclosure having an insulating material, and a motor or an actuator disposed within the enclosure. The chamber includes an inlet tube coupled with the enclosure at a first end and a first wall of the chamber at a second end. In one aspect, a method for determining material performance includes exposing a material system to a relative humidity of from 0% to 98% and flexing the material system at a first temperature in a chamber, the chamber comprising an enclosure disposed within the chamber and a motor disposed within the enclosure. The method includes operating the motor at a second temperature different from the first temperature during the flexing.

Abstract: In one aspect, an apparatus includes a chamber configured to control one or more of humidity, pressure, or temperature and a jaw configured to flex a material system. The chamber includes an enclosure disposed within the chamber, the enclosure having an insulating material, and a motor or an actuator disposed within the enclosure. The chamber includes an inlet tube coupled with the enclosure at a first end and a first wall of the chamber at a second end. In one aspect, a method for determining material performance includes exposing a material system to a relative humidity of from 0% to 98% and flexing the material system at a first temperature in a chamber, the chamber comprising an enclosure disposed within the chamber and a motor disposed within the enclosure. The method includes operating the motor at a second temperature different from the first temperature during the flexing.

Abstract: A method and apparatus for analyzing potential corrosion for a vehicle. Potential corrosion surfaces for the vehicle are identified using a model for the vehicle. The corrosion risks are predicted for each of the potential corrosion surfaces. The corrosion risks predicted are aggregated into a group of aggregated corrosion risks for a group of functional design units for the vehicle. A corrosion risk assessment for the vehicle is generated to identify a corrosion risk in the vehicle from the group of aggregated corrosion risks, and to enable a change in the model to reduce the identified corrosion risk.

Abstract: The disclosure provides methods for determining the self-renewal potential of a cancer stem cell (CSC), or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting the progression of a cancer that corresponds to the CSC. In alternative embodiments, the disclosure provides methods for determining whether a CSC in a niche is more pro-apoptotic or more anti-apoptotic in relation to a normal stem cell or a CSC from another niche. In alternative embodiments, the disclosure provides methods for determining the prognosis or malignant potential of a cancer. In alternative embodiments, the disclosure provides methods determining the anti-apoptotic versus a pro-apoptotic potential of a cancer stem cell (CSC).

Abstract: A method and apparatus for analyzing potential corrosion for a vehicle. Potential corrosion surfaces for the vehicle are identified using a model for the vehicle. The corrosion risks are predicted for each of the potential corrosion surfaces. The corrosion risks predicted are aggregated into a group of aggregated corrosion risks for a group of functional design units for the vehicle. A corrosion risk assessment for the vehicle is generated to identify a corrosion risk in the vehicle from the group of aggregated corrosion risks, and to enable a change in the model to reduce the identified corrosion risk.

Abstract: The disclosure provides methods for determining the self-renewal potential of a cancer stem cell (CSC), or for predicting the drugability (susceptibility to a drug) of a CSC, and/or for predicting the progression of a cancer that corresponds to the CSC. In alternative embodiments, the disclosure provides methods for determining whether a CSC in a niche is more pro-apoptotic or more anti-apoptotic in relation to a normal stem cell or a CSC from another niche. In alternative embodiments, the disclosure provides methods for determining the prognosis or malignant potential of a cancer. In alternative embodiments, the disclosure provides methods determining the anti-apoptotic versus a pro-apoptotic potential of a cancer stem cell (CSC).

Abstract: We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.

Abstract: We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.

Abstract: We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.

Abstract: A pet collar in which a leash attachment is connected to a back edge of the collar band, at a location generally opposite to the collar buckle, and extends rearwardly from the back edge, leaving the entire area of the collar band unobstructed by the leash attachment. Decorative elements can be attached to the collar in the region of the leash attachment, either directly or by means of a slide strip, without visual obstruction by, or mechanical interference from the leash attachment. The pet owner thus has a clear view the decorative elements when walking the pet on a leash.

Abstract: Disclosed are neuroblastoma tumor-initiating cell inhibiting compositions comprising chemical entities capable of affecting neuroblastoma tumor-initiating cells. Pharmaceutical preparations that include these chemical entities are also provided for the treatment of neuroblastoma. These pharmaceutical preparations are suitable for the treatment of humans, and are particularly suited for the treatment of children of 12 years of age or younger having neuroblastoma. The compositions and pharmaceutical preparations posses reduced normal cell cytotoxicity. The compositions and pharmaceutical preparations may be used alone or together with other conventional neuroblastoma preparations as part of a clinical regimen in the treatment and management of neuroblastoma.

Abstract: A stackable cleaner or product applicator is described in which a rigid applicator body has a downwardly opening compartment surrounded by a skirt and an upper compartment surrounded by an upwardly extending wall, the upper compartment containing a foam body and fluid or gel and being closed by means of a removable top wall fixed to the top periphery of the upwardly extending wall. The downwardly extending skirt is sized to accept the upwardly extending wall of an identical unit whereby multiple units may be stacked in a nested configuration.

Abstract: A new and distinct variety of rose plant, referred to by its cultivar name, ‘MEIJOVAUX’, is disclosed. The new variety forms attractive, semi-double creamy pink with a creamy yellow center colored flowers. Attractive rather dense with a semi-glossy aspect foliage is formed, which contrasts beautifully with the blossoms. A ground cover growth habit is displayed. The new variety is well suited for providing attractive ornamentation in the landscape.