Patents by Inventor Kristi Helen Piehl

Kristi Helen Piehl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20220098327
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: June 23, 2021
    Publication date: March 31, 2022
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
    Patent number: 11078299
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: August 3, 2021
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
    Patent number: 10941214
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: March 9, 2021
    Assignees: aTyr Pharma, Inc., Paneu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20200231704
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 23, 2020
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20200216564
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: November 19, 2019
    Publication date: July 9, 2020
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
    Patent number: 10526419
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: January 7, 2020
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20190031775
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: June 11, 2018
    Publication date: January 31, 2019
    Inventors: Jie ZHOU, Ching-Fun LAU, Zhiwen Xu, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
  • Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities
    Patent number: 10017582
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 10, 2018
    Assignees: aTyr Pharma, Inc., Pangu Biopharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Aminoacyl tRNA synthetases for modulating inflammation
    Patent number: 9943577
    Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: April 17, 2018
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
  • Aspartyl-tRNA synthetases
    Patent number: 9816084
    Abstract: The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 14, 2017
    Assignee: aTyr Pharma, Inc.
    Inventors: Ying Ji Buechler, Chi-Fang Wu, Ryan Andrew Adams, Kristi Helen Piehl, Jeffrey Greve, John D. Mendlein
  • COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20170296635
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: January 25, 2017
    Publication date: October 19, 2017
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • AMINOACYL TRNA SYNTHETASES FOR MODULATING INFLAMMATION
    Publication number: 20170202933
    Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
    Type: Application
    Filed: November 30, 2016
    Publication date: July 20, 2017
    Inventors: Jeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
  • COMPOSITIONS AND METHODS COMPRISING HISTIDYL-TRNA SYNTHETASE SPLICE VARIANTS HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20170114148
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: September 6, 2016
    Publication date: April 27, 2017
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
    Patent number: 9605265
    Abstract: Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: March 28, 2017
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
  • Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities
    Patent number: 9585946
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: March 7, 2017
    Assignee: aTyr Pharma, Inc.
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • Aminoacyl tRNA synthetases for modulating inflammation
    Patent number: 9540628
    Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 10, 2017
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
  • Amino acyl tRNA synthetases for modulating inflammation
    Patent number: 9328340
    Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: May 3, 2016
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
  • COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
    Publication number: 20160114016
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Application
    Filed: September 3, 2015
    Publication date: April 28, 2016
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities
    Patent number: 9157076
    Abstract: Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: October 13, 2015
    Assignee: aTyr Pharma, Inc.
    Inventors: Leslie Ann Greene, Ryan Andrew Adams, Fei Hong, Ji Zhao, Eva Rebecka Stephanie Armour, Kristi Helen Piehl
  • Aminoacyl tRNA synthetases for modulating inflammation
    Patent number: 9127268
    Abstract: Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 8, 2015
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kristi Helen Piehl, Fei Hong, Kyle P. Chiang, Wei Zhang, Alina He