Abstract: Stents comprising a first region and a second region are provided, where at least the second region comprises one or more phase transforming cellular materials configured to move the outlet between an open configuration and a closed configuration in response to certain triggers. Such stents can also comprise one or more analog for a shape memory alloy (ASMA) unit cells on an inner surface of the first region such that, in response to resistive forces, the ASMA unit cells exert controllable motion to clear the stent. Methods of treatment of cancer, jaundice, and other diseases are also provided.