Patents by Inventor Kristian Larsen
Kristian Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240041699Abstract: A device for reconstituting a bioactive agent and forming a flowable paste is described. The device comprises a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.Type: ApplicationFiled: October 20, 2023Publication date: February 8, 2024Inventors: Kristian Larsen, Peter Lund Hammershøj
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Publication number: 20240009345Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Inventors: Peter Lund Hammershøj, Kristian Larsen, Douglas B. Johns, Nicole Smith, Michael Cardinale, Gabriella Ferrara, Guanghui Zhang
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Patent number: 11865077Abstract: The invention regards a device for reconstituting a bioactive agent and forming a flowable paste, the device comprising: —a base configured for receiving: —a first container containing a liquid, and —a second container containing the bioactive agent, —a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.Type: GrantFiled: June 26, 2019Date of Patent: January 9, 2024Assignee: Ferrosan Medical Devices A/SInventors: Kristian Larsen, Peter Lund Hammershøj
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Patent number: 11801324Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.Type: GrantFiled: May 9, 2019Date of Patent: October 31, 2023Assignees: Ferrosan Medical Devices A/S, Ethicon Inc.Inventors: Peter Lund Hammershøj, Kristian Larsen, Douglas B. Johns, Nicole Smith, Michael Cardinale, Gabriella Ferrara, Guanghui Zhang
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Patent number: 11109849Abstract: The present invention relates to a container adapted to dispense its content under pressure. The container of the present invention consists of two separate compartments separated from one another by a slidable piston. The container of the present invention contains a haemostatic paste.Type: GrantFiled: March 5, 2013Date of Patent: September 7, 2021Assignee: FERROSAN MEDICAL DEVICES A/SInventors: Mette Krog Jensen, Kristian Larsen
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Patent number: 11103616Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.Type: GrantFiled: September 12, 2018Date of Patent: August 31, 2021Assignee: FERROSAN MEDICAL DEVICES A/SInventor: Kristian Larsen
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Publication number: 20210244616Abstract: The invention regards a device for reconstituting a bioactive agent and forming a flowable paste, the device comprising: a base configured for receiving: a first container containing a liquid, and a second container containing the bioactive agent, a syringe containing a paste forming material, the syringe being attachable to the base, wherein the base has a first conduit for fluidly connecting the first container with the second container and a second conduit for fluidly connecting the second container with the syringe, and wherein the first container is configured to be pressurizable such that when the first and second containers are received at the base, the liquid is forced through the first conduit into the second container, thereby reconstituting the bioactive agent, and the reconstituted bioactive agent is forced through the second conduit into the syringe, such that a paste is formed.Type: ApplicationFiled: June 26, 2019Publication date: August 12, 2021Inventors: Kristian Larsen, Peter Lund Hammershøj
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Publication number: 20210219969Abstract: The invention regards a device for reconstituting a bioactive agent and forming a paste, the device comprising: —a container (2) containing the bioactive agent, —a first syringe (4) containing a liquid, —a second syringe (5) containing a paste forming material, —a connector element (6) configured for establishing sequential fluid connections between 1) the first syringe and the container, 2) the container and the second syringe, and 3) the first and second syringes, such that the liquid can be transferred from the first syringe to the container to reconstitute the bioactive agent, whereupon the reconstituted bioactive agent can be transferred from the container into the second syringe to form a paste, and the paste can be transferred to the first syringe.Type: ApplicationFiled: June 26, 2019Publication date: July 22, 2021Inventors: Kristian Larsen, Peter Lund Hammershøj
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Patent number: 11046818Abstract: The present disclosure relates to a dry composition which reconstitutes without mechanical mixing to form a flowable paste having a soft and light consistency suitable for use in haemostasis and wound healing procedures upon addition of an aqueous medium. The disclosure further relates to methods of preparing the dry composition, methods for reconstituting the dry composition and medical use of the composition.Type: GrantFiled: October 13, 2015Date of Patent: June 29, 2021Assignee: Ferrosan Medical Devices A/SInventors: Kristian Larsen, Flemming Reissig Jensen, Michael Wrang Mortensen
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Patent number: 10918796Abstract: A syringe for mixing two substances which have been retained separately inside the syringe is described, for instance in a storage condition. The syringe is used for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment, a syringe for retaining and mixing first and second substances comprises a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane, wherein the syringe is configured such that the membrane and the pointed member are axially slidable in relation to each other.Type: GrantFiled: June 30, 2016Date of Patent: February 16, 2021Assignee: Ferrosan Medical Devices A/SInventors: Kristian Larsen, Lise Sjørup Elle, Thomas Ingemann Jensen
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Patent number: 10799611Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.Type: GrantFiled: April 26, 2018Date of Patent: October 13, 2020Assignee: Ferrosan Medical Devices A/SInventor: Kristian Larsen
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Patent number: 10653837Abstract: The present disclosure relates to a syringe for retaining and/or mixing two substances which have been retained separately inside the syringe. In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for mixing first and second substances comprising a barrel comprising a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced in the vacuum chamber, and a valve for controlling and/or establishing a fluid connection between the vacuum chamber and the reservoir chamber.Type: GrantFiled: December 21, 2015Date of Patent: May 19, 2020Assignee: Ferrosan Medical Devices A/SInventor: Kristian Larsen
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Publication number: 20200140625Abstract: The present disclosure relates to a dry composition which reconstitutes without mechanical mixing to form a flowable paste having a soft and light consistency suitable for use in haemostasis and wound healing procedures upon addition of an aqueous medium. The disclosure further relates to methods of preparing the dry composition, methods for reconstituting the dry composition and medical use of the composition.Type: ApplicationFiled: October 13, 2015Publication date: May 7, 2020Inventors: Kristian Larsen, Flemming Reissig Jensen, Michael Wrang Mortensen
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Patent number: 10595837Abstract: The present disclosure relates to a method for vacuum expansion of a paste prior to freeze-drying said paste to achieve a dry paste composition which reconstitutes efficiently to form a flowable paste upon addition of an aqueous medium. The present disclosure further relates to a syringe for retaining a dry paste composition in a vacuum.Type: GrantFiled: June 30, 2017Date of Patent: March 24, 2020Assignee: Ferrosan Medical Devices A/SInventors: Kristian Larsen, Michael Wrang Mortensen
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Publication number: 20190343981Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.Type: ApplicationFiled: May 9, 2019Publication date: November 14, 2019Inventors: Peter Lund Hammershøj, Kristian Larsen, Douglas B. Johns, Nicole Smith, Michael Cardinale, Gabriella Ferrara, Guanghui Zhang
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Publication number: 20190015546Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.Type: ApplicationFiled: September 12, 2018Publication date: January 17, 2019Inventor: Kristian Larsen
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Patent number: 10111980Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.Type: GrantFiled: December 10, 2014Date of Patent: October 30, 2018Assignee: Ferrosan Medical Devices A/SInventor: Kristian Larsen
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Publication number: 20180264194Abstract: The present disclosure relates to a syringe for retaining and/or mixing two substances which have been retained separately inside the syringe. In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for mixing first and second substances comprising a barrel comprising a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced in the vacuum chamber, and a valve for controlling and/or establishing a fluid connection between the vacuum chamber and the reservoir chamber.Type: ApplicationFiled: December 21, 2015Publication date: September 20, 2018Inventor: Kristian Larsen
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Publication number: 20180243468Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.Type: ApplicationFiled: April 26, 2018Publication date: August 30, 2018Inventor: Kristian Larsen
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Patent number: 9999703Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.Type: GrantFiled: December 28, 2015Date of Patent: June 19, 2018Assignee: Ferrosan Medical Devices A/SInventor: Kristian Larsen